A clinical case of composite pheochromocytoma in a child and a literature review

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Abstract

Composite pheochromocytoma (CPh) is a rare malignant neoplasm that occurs in different age ranges. The main treatment for pheochromocytoma is a complete surgical removal of the tumor, while in the case of neuroblastoma, risk-adapted therapy is used, depending on the risk group, including chemotherapy, autologous bone marrow transplantation, radiation therapy, immunotherapy and 131I-metaiodbenzylguanidine therapy. Due to the rarity of CPh, there are no standard approaches to systemic therapy. The tactics and extent of treatment are determined according to the predominance of the tumor malignant component. This article presents a rare case of the development of composite pheochromocytoma with poorly differentiated neuroblastoma of the left adrenal gland in a 4-year-old child. The patient’s parents gave consent to the use of their child’s data, including photographs, for research purposes and in publications.

About the authors

G. B. Sagoyan

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: sagoyan-garik@mail.ru
ORCID iD: 0000-0002-7846-3473

Garik B. Sagoyan, a researcher, a pediatric oncologist at the Research Institute of Pediatric Oncology and Hematology

115478, Moscow, Kashirskoe shosse, 23

Россия

A. M. Suleymanova

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-5489-1879

Moscow

Россия

I. V. Sidorov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-8578-6572

Moscow

Россия

S. A. Sardalova

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-3328-0988

Moscow

Россия

M. V. Rubanskaya

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0002-1016-539X

Moscow

Россия

A. S. Temnyy

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-9774-8039

Moscow

Россия

O. A. Ignatenko

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-2794-6886

Moscow

Россия

A. A. Odzharova

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-3576-6156

Moscow

Россия

D. M. Konovalov

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-7732-8184

Moscow

Россия

O. L. Kosilo

N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0003-3463-3626

Moscow

Россия

A. P. Kazantsev

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-7309-1650

Moscow

Россия

S. R. Varfolomeeva

N.N. Blokhin National Medical Research Center of Oncology of Ministry of Healthcare of the Russian Federation

ORCID iD: 0000-0001-6131-1783

Moscow

Россия

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