Second allogeneic hematopoietic stem cell transplantation as salvage therapy in a patient with sepsis and severe hypofunction of hematopoiesis after chemotherapy

D. E. Klevakin; Клевакин Д. Э.; L. V. Vakhonina; Вахонина Л. В.; A. A. Vlasova; Власова А. А.; D. E. Kostenko; Костенко Д. Е.; S. V. Borovskikh; Боровских С. В.; А. D. Tarasova; Тарасова А. Д.; L. G. Fechina; Фечина Л. Г.

doi:10.24287/1726-1708-2024-23-3-164-168

Second allogeneic hematopoietic stem cell transplantation as salvage therapy in a patient with sepsis and severe hypofunction of hematopoiesis after chemotherapy

Authors: Klevakin D.E.¹, Vakhonina L.V.¹, Vlasova A.A.¹, Kostenko D.E.¹, Borovskikh S.V.¹, Tarasova А.D.¹, Fechina L.G.¹
Affiliations:
1. Pediatric Oncology and Hematology Center, Regional Children’s Clinical Hospital
Issue: Vol 23, No 3 (2024)
Pages: 164-168
Section: CLINICAL OBSERVATIONS
Submitted: 16.10.2024
Accepted: 16.10.2024
Published: 08.07.2025
URL: https://hemoncim.com/jour/article/view/903
DOI: https://doi.org/10.24287/1726-1708-2024-23-3-164-168
ID: 903

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Abstract

When performed in patients with severe infection, allogeneic hematopoietic stem cell transplantation is associated with high mortality rates due to the progression of infection and graft failure. Here, we report a case of a successful allogeneic hematopoietic stem cell transplantation performed in a pediatric patient with B-cell acute lymphoblastic leukemia who developed persistent granulocyte colony-stimulating factor refractory chemotherapy-induced myelosuppression and severe sepsis. Following the procedure, the patient achieved hematopoietic recovery with subsequent resolution of the infection and was able to resume treatment. The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.