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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">100</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2015-14-2-20-37</article-id><article-categories><subj-group subj-group-type="toc-heading"><subject>ЛИМФОМЫ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Role of monoclonal antibodies in therapy of lymphoproliferative disorders</article-title><trans-title-group xml:lang="ru"><trans-title>Роль моноклональных антител в терапии лимфопролиферативных заболеваний</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Von Stackelberg</surname><given-names>A. .</given-names></name><name xml:lang="ru"><surname>Von Stackelberg</surname><given-names>Arend</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>arend.stackelberg@charite.de</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Romanova</surname><given-names>K. I.</given-names></name><name xml:lang="ru"><surname>Романова</surname><given-names>Ксения Игоревна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>romanovaksen@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff id="aff1"><institution>Charité-Universitaetsmedizin Berlin</institution></aff><aff id="aff2"><institution>Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России</institution></aff><pub-date date-type="pub" iso-8601-date="2015-05-19" publication-format="electronic"><day>19</day><month>05</month><year>2015</year></pub-date><volume>14</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>20</fpage><lpage>37</lpage><history><date date-type="received" iso-8601-date="2018-09-19"><day>19</day><month>09</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/100">https://hemoncim.com/jour/article/view/100</self-uri><abstract xml:lang="en"><p>The development of monoclonal antibodies (mAbs) for the treatment of hematological malignancies is in the focus of modern research. Several antibodies (Abs) effective in the treatment of acute lymphoblastic leukemia (ALL) in children are used at present. Nonconjugated humanized Abs are well tolerated and can be combined with chemotherapy, while immunoconjugats (with a second molecule - toxin, radioisotope, or label), delivering toxic compounds directly to the target cells, are fraught with serious side effects. Antigens with high selective expression on pathological cells are the ideal targets for Abs, their clinical trials (phases I/II and III) in children with ALL are now in progress. Antigens with stable expression on cell membrane (CD19, CD52) serve as substrates for bi-specific T-cell engagers (BiTEs) or for nonconjugated Abs realizing their mechanism of action through antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Antigens subjected to rapid internalization (CD22, CD5, CD7) are suitable targets for immunoconjugates delivering toxic substances directly to target cells by specific binding. Effective compounds, corresponding to various antigens expressed in only certain ALL subgroups (CD20, CD33, CD2, CD3, CD4), can be used for therapy of patients with refractory leukemias. The mechanism of antileukemic activity of mAbs is quite different in comparison with chemotherapy; this approach is expected to modify significantly the therapeutic strategy in childhood ALL.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="ru"><kwd>острый лимфобластный лейкоз</kwd><kwd>лимфома</kwd><kwd>моноклональные антитела</kwd><kwd>терапия</kwd><kwd>acute lymphocytic leukemia</kwd><kwd>lymphoma</kwd><kwd>monoclonal antibodies</kwd><kwd>therapy</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Köhler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature. 1975;256(5517):495-7.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Riechmann L, Clark M, Waldmann H, Winter G. Reshaping human antibodies for therapy. 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