<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">1036</article-id><article-id pub-id-type="doi">10.24287/j.1036</article-id><article-id pub-id-type="edn">TLGNYI</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Robot-assisted laparoscopic adrenalectomy – first experience of use in children</article-title><trans-title-group xml:lang="ru"><trans-title>Робот-ассистированная лапароскопическая адреналэктомия – первый опыт использования у детей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2313-897X</contrib-id><name-alternatives><name xml:lang="en"><surname>Kozlov</surname><given-names>Yury A.</given-names></name><name xml:lang="ru"><surname>Козлов</surname><given-names>Юрий Андреевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Irkutsk State Medical Academy of Postgraduate Education; Corresponding Member of the RAS, Dr. Med. Sci., Professor, Chief Physician of Irkutsk State Regional Children's Clinical Hospital; Head of the Department of Pediatrics and Pediatric Surgery at Irkutsk State Medical University; Professor at the Department of Pediatric Surgery of Irkutsk State Medical Academy of Postgraduate Education</p></bio><bio xml:lang="ru"><p>Иркутская государственная медицинская академия последипломного образования; член-корреспондент РАН, д-р мед. наук, профессор, главный врач ИГОДКБ; заведующий кафедрой педиатрии и детской хирургии ИГМУ; профессор кафедры детской хирургии ИГМАПО</p></bio><email>yuriherz@hotmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7922-7600</contrib-id><name-alternatives><name xml:lang="en"><surname>Rozhansky</surname><given-names>A. P.</given-names></name><name xml:lang="ru"><surname>Рожанский</surname><given-names>А. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>yuriherz@hotmail.com</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5470-7384</contrib-id><name-alternatives><name xml:lang="en"><surname>Sapukhin</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Сапухин</surname><given-names>Э. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>yuriherz@hotmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9767-0454</contrib-id><name-alternatives><name xml:lang="en"><surname>Marchuk</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Марчук</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>yuriherz@hotmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9049-0450</contrib-id><name-alternatives><name xml:lang="en"><surname>Semshchikova</surname><given-names>Yu. P.</given-names></name><name xml:lang="ru"><surname>Съемщикова</surname><given-names>Ю. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>yuriherz@hotmail.com</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8295-6687</contrib-id><name-alternatives><name xml:lang="en"><surname>Makarochkina</surname><given-names>M. V.</given-names></name><name xml:lang="ru"><surname>Макарочкина</surname><given-names>М. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>yuriherz@hotmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Irkutsk State Regional Children's Clinical Hospital</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Иркутская государственная областная детская клиническая больница»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian Medical Academy of Continuing Professional Education of Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Irkutsk State Medical University of Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2026-08-19" publication-format="electronic"><day>19</day><month>08</month><year>2026</year></pub-date><volume>25</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>180</fpage><lpage>187</lpage><history><date date-type="received" iso-8601-date="2025-10-08"><day>08</day><month>10</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2026-01-29"><day>29</day><month>01</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/1036">https://hemoncim.com/jour/article/view/1036</self-uri><abstract xml:lang="en"><p><bold>The aim of this publication</bold> is to demonstrate the reproducibility and safety of the robotic-assisted approach in children with adrenal tumors.</p> <p><bold>Clinical case.</bold> A 15-year-old adolescent with an adrenal tumor was diagnosed incidentally during a routine visit to the emergency room due to the sudden onset of a right-sided hydrocele. After performing an ultrasound examination, a 43 × 41 mm tumor was detected in the projection of the right adrenal gland. Subsequent computed tomography confirmed the organ affiliation of the tumor associated with the right adrenal gland. Robot-assisted laparoscopic adrenalectomy was performed using the Versius surgical robot. Initially, the hepatic flexure of the colon was mobilized, exposing the inferior vena cava, spread out on the surface of the tumor. The adrenal vein was isolated, ligated using Hem-o-lok<sup>®</sup> clips (Teleflex, USA) and transected. Then the adrenal gland together with the tumor was carefully mobilized from the medial side by coagulation of adhesions connecting it to the inferior vena cava. Small adrenal vessels were coagulated with bi- and monopolar robotic instruments (Maryland clamp and hook) from the cranial and lateral surfaces, which allowed complete tumor resection. The adrenal gland was removed externally using a tissue removal bag. Tumor resection was performed completely robotically without conversion to laparoscopy or open surgery. Tumor resection was macroscopically complete. The duration of the operation was 180 min, the net console time was 165 min. We did not observe any intraoperative complications, such as bleeding, damage to adjacent organs, injuries associated with the impact of manipulators on the anterior abdominal wall. The child was discharged from the hospital on the 5th postoperative day. The postoperative period was uneventful. The removed pathological tissue sample, upon histological examination, corresponded to a ganglioneuroma formed from mature ganglion cells and sympathetic nerve ganglia.</p> <p><bold>Conclusion.</bold> The presented case demonstrates that adrenalectomy can be performed using robotics due to its advantages, which include improved visualization and increased maneuverability when working with robotic instruments.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Цель настоящей публикации</bold> – продемонстрировать воспроизводимость и безопасность робот-ассистированного подхода у детей с опухолями надпочечника.</p> <p><bold>Клинический случай.</bold> При плановом обращении в приемный покой в связи с внезапным появлением правостороннего гидроцеле у 15-летнего подростка случайно была диагностирована опухоль надпочечника. После выполнения ультразвукового исследования в проекции правого надпочечника обнаружена опухоль размерами 43 × 41 мм. Последующая компьютерная томография подтвердила органную принадлежность опухоли, связанную с правым надпочечником. Робот-ассистированная лапароскопическая адреналэктомия выполнялась с помощью хирургического робота Versius. Первоначально проводилась мобилизация печеночного изгиба толстой кишки, обнажая нижнюю полую вену, распластанную на поверхности опухоли. Надпочечниковая вена была выделена, лигирована с помощью клипс Hem-o-lok<sup>®</sup> (Teleflex, США) и пересечена. Затем надпочечник вместе с опухолью был аккуратно мобилизован с медиальной стороны путем коагуляции сращений, связывающих его с нижней полой веной. Мелкие надпочечниковые сосуды были коагулированы би- и монополярными роботическими инструментами (зажим Maryland и крючок) с краниальной и латеральной поверхности, что позволило полностью удалить опухоль. Надпочечник извлекался наружу с помощью мешка для удаления тканей. Резекция опухоли полностью была выполнена роботическим способом без конверсии в лапароскопию или открытую хирургию, она была макроскопически полной. Длительность операции составила 180 мин, чистое консольное время – 165 мин. Мы не наблюдали интраоперационных осложнений, таких как кровотечение, повреждение соседних органов, травм, связанных с воздействием манипуляторов на переднюю брюшную стенку. Ребенок был выписан из больницы на 5-й послеоперационный день. Послеоперационный период прошел без осложнений. Удаленный патологический образец тканей при гистологическом исследовании соответствовал ганглионевроме, сформированной из зрелых ганглионарных клеток и симпатических нервных узлов.</p> <p><bold>Заключение.</bold> Представленный случай показывает, что адреналэктомию можно выполнить с помощью робототехники, благодаря ее преимуществам, которые заключаются в улучшенной визуализации и повышенной маневренности при работе роботическими инструментами.</p></trans-abstract><kwd-group xml:lang="en"><kwd>robot-assisted surgery</kwd><kwd>adrenalectomy</kwd><kwd>neuroblastoma</kwd><kwd>children</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>робот-ассистированная хирургия</kwd><kwd>адреналэктомия</kwd><kwd>ганглионеврома</kwd><kwd>дети</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Mora Fritis C., Ruiz-Tagle P.G., Vuletin Solis J.F., Sáez Binelli J., Pattillo Silva J.C. Tumores suprarrenales en pacientes pediátricos tratados mediante técnica quirúrgica mínimamente invasiva [Adrenal tumors in pediatric patients treated with minimally invasive surgery]. Andes Pediatr 2024;95(5):613–9. [Spanish]. DOI: 10.32641/andespediatr.v95i5.5157</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Taghavi K., Glenisson M., Loiselet K., Fiorenza V., Cornet M., Capito C. et al. Robot-assisted laparoscopic adrenalectomy: extended application in children. Eur J Surg Oncol 2024;50(12):108627. DOI: 10.1016/j.ejso.2024.108627</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Zhang K., Zhang Y., Zhang Y., Chao M. A retrospective analysis of the clinical characteristics of 207 hospitalized children with adrenal masses. Front Pediatr 2023;11:1215095. DOI: 10.3389/fped.2023.1215095</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Zhang R., Fang Y.F., Wu D.M., Lin Y., Zhang B., Liu M.K. et al. Comparison of the efficacy of minimally invasive and open surgery on children with neuroblastoma: a meta-analysis. J Laparoendosc Adv Surg Tech A 2021;31(7):829–38. DOI: 10.1089/lap.2020.0618</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Iwanaka T., Arai M., Ito M., Kawashima H., Yamamoto K., Hanada R., Imaizumi S. Surgical treatment for abdominal neuroblastoma in the laparoscopic era. Surg Endosc 2001;15(7):751–4. DOI: 10.1007/s004640080074</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Vuotto S.C., Ojha R.P., Li C., Kimberg C., Klosky J.L., Krull K.R. et al. The role of body image dissatisfaction in the association between treatment-related scarring or disfigurement and psychological distress in adult survivors of childhood cancer. Psychooncology 2018;27(1):216–22. doi: 10.1002/pon.4439</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Mei H., Tang S. Robotic-assisted surgery in the pediatric surgeons' world: Current situation and future prospectives. Front Pediatr 2023;11:1120831. DOI: 10.3389/fped.2023.1120831</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Steyaert H., Van Der Veken E., Joyeux L. Implementation of robotic surgery in a pediatric hospital: lessons learned. J Laparoendosc Adv Surg Tech A 2019;29(2):136–40. DOI: 10.1089/lap.2018.0426</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Brandao L.F., Autorino R., Laydner H., Haber G.P., Ouzaid I., De Sio M. Robotic versus laparoscopic adrenalectomy: a systematic review and meta-analysis. Eur Urol 2014;65(6):1154-61. DOI: 10.1016/j.eururo.2013.09.021</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Agrusa A., Romano G., Navarra G., Conzo G., Pantuso G., Buono G.D. et al. Innovation in endocrine surgery: robotic versus laparoscopic adrenalectomy. Meta-analysis and systematic literature review. Oncotarget 2017;8(60):102392–400. DOI: 10.18632/oncotarget.22059</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Holloway R.W., Patel S.D., Ahmad S. Robotic surgery in gynecology. Scand J Surg 2009;98(2):96–109. DOI: 10.1177/145749690909800205</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Park J.R., Bagatell R., London W.B., Maris J.M., Cohn S.L., Mattay K.K., Hogarty M.; COG Neuroblastoma Committee. Children's Oncology Group's 2013 blueprint for research: neuroblastoma. Pediatr Blood Cancer 2013;60(6):985–93. DOI: 10.1002/pbc.24433. Erratum in: Pediatr Blood Cancer 2014;61(5):958. Mattay K.M. [corrected to Mattay K.K.].</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Uwaydah N.I., Jones A., Elkaissi M., Yu Z., Palmer B.W. Pediatric robot-assisted laparoscopic radical adrenalectomy and lymph-node dissection for neuroblastoma in a 15-month-old. J Robot Surg 2014;8(3):289–93. DOI: 10.1007/s11701-013-0441-0</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Strother D.R., London W.B., Schmidt M.L., Brodeur G.M., Shimada H., Thorner P. et al. Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma: results of Children's Oncology Group study P9641. J Clin Oncol 2012;30(15):1842–8. DOI: 10.1200/JCO.2011.37.9990</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>International Pediatric Endosurgery Group. IPEG guidelines for the surgical treatment of adrenal masses in children. J Laparoendosc Adv Surg Tech A 2010;20(2):vii–ix. DOI: 10.1089/lap.2010.9999</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Lenders J.W., Duh Q.Y., Eisenhofer G., Gimenez-Roqueplo A.P., Grebe S.K., Murad M.H. et al.; Endocrine Society. Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2014;99(6):1915–42. DOI: 10.1210/jc.2014-1498. Erratum in: J Clin Endocrinol Metab 2023;108(5):e200. DOI: 10.1210/clinem/dgad064</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Gurria J.P., Malek M.M., Heaton T.E., Gehred A., Lautz T.B., Rhee D.S. et al. Minimally invasive surgery for abdominal and thoracic neuroblastic tumors: A systematic review by the APSA Cancer committee. J Pediatr Surg 2020;55(11):2260–72. DOI: 10.1016/j.jpedsurg.2020.02.019</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Gabra H.O., Irtan S., Cross K., Lobos P., Froeba-Pohl A., Pio L. et al. Minimally invasive surgery for neuroblastic tumours: a SIOPEN multicentre study: Proposal for guidelines. Eur J Surg Oncol 2022;48(1):283–91. DOI: 10.1016/j.ejso.2021.08.013</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Denning N.L., Kallis M.P., Prince J.M. Pediatric robotic surgery. Surg Clin North Am 2020;100(2):431–43. DOI: 10.1016/j.suc.2019.12.004</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Rogers C.G., Blatt A.M., Miles G.E., Linehan W.M., Pinto P.A. Concurrent robotic partial adrenalectomy and extra-adrenal pheochromocytoma resection in a pediatric patient with von Hippel-Lindau disease. J Endourol 2008;22(7):1501–3. DOI: 10.1089/end.2007.0314</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Mitra A.P., Vasquez E., Kokorowski P., Chang A.Y. Robotic adrenalectomy in the pediatric population: initial experience case series from a tertiary center. BMC Urol 2020;20(1):155. DOI: 10.1186/s12894-020-00727-x</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>de Lambert G., Fourcade L., Centi J., Fredon F., Braik K., Szwarc C. et al. How to successfully implement a robotic pediatric surgery program: lessons learned after 96 procedures. Surg Endosc 2013;27(6):2137–44. DOI: 10.1007/s00464-012-2729-y</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Meignan P., Ballouhey Q., Lejeune J., Braik K., Longis B., Cook A.R. et al. Robotic-assisted laparoscopic surgery for pediatric tumors: a bicenter experience. J Robot Surg 2018;12(3):501–8. DOI: 10.1007/s11701-017-0773-2</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Navarrete Arellano M., Garibay González F. Robot-assisted laparoscopic and thoracoscopic surgery: prospective series of 186 pediatric surgeries. Front Pediatr 2019;7:200. DOI: 10.3389/fped.2019.00200</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Chen D.X., Hou Y.H., Jiang Y.N., Shao L.W., Wang S.J., Wang X.Q. Removal of pediatric stage IV neuroblastoma by robot-assisted laparoscopy: a case report and literature review. World J Clin Cases 2019;7(12):1499–507. DOI: 10.12998/wjcc.v7.i12.1499</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Lowrey T., Cochran D., Frimberger D., Sundaram B.M., Mercer S., Rensing A. Pediatric robotic adrenalectomy for virilizing adrenal tumor in a 4-year-old female. Urology 2021;156:260–2. DOI: 10.1016/j.urology.2021.02.030</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Vinit N., Vatta F., Broch A., Hidalgo M., Kohaut J., Querciagrossa S. et al. Adverse events and morbidity in a multidisciplinary pediatric robotic surgery program. A prospective, observational study. Ann Surg 2023;278(5):e932–8. DOI: 10.1097/SLA.0000000000005808</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Sakoda A., Mushtaq I., Levitt G., Sebire N.J. Clinical and histopathological features of adrenocortical neoplasms in children: retrospective review from a single specialist center. J Pediatr Surg 2014;49(3):410–5. DOI: 10.1016/j.jpedsurg.2013.09.008</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Blanc T., Meignan P., Vinit N., Ballouhey Q., Pio L., Capito C. et al. Robotic surgery in pediatric oncology: lessons learned from the first 100 tumors – a nationwide experience. Ann Surg Oncol 2022;29(2):1315–26. DOI: 10.1245/s10434-021-10777-6. Erratum in: Ann Surg Oncol 2021;28(Suppl 3):901. doi: 10.1245/s10434-021-10861-x</mixed-citation></ref></ref-list></back></article>
