<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">127</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2016-15-4-5-12</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>HEMATOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ГЕМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">A comparative efficacy and safety of using ferrous and ferric iron preparations for management of iron-deficiency anaemia</article-title><trans-title-group xml:lang="ru"><trans-title>Сравнительная эффективность и безопасность применения препаратов двухи трехвалентного железа для лечения железодефицитной анемии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lebedev</surname><given-names>Vyacheslav V.</given-names></name><name xml:lang="ru"><surname>Лебедев</surname><given-names>Вячеслав Вячеславович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>lebedev@hemacenter.org</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Demikhov</surname><given-names>Valeriy G.</given-names></name><name xml:lang="ru"><surname>Демихов</surname><given-names>Валерий Григорьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>demix777@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dmitriev</surname><given-names>Andrey V.</given-names></name><name xml:lang="ru"><surname>Дмитриев</surname><given-names>Андрей Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>aakavd@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Aiari</surname><given-names>Manel</given-names></name><name xml:lang="ru"><surname>Аиари</surname><given-names>Манел</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>manoukrasiva@gmail.com</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fomina</surname><given-names>Maria A.</given-names></name><name xml:lang="ru"><surname>Фомина</surname><given-names>Мария Алексеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Academician I.P.Pavlov Ryazan State Medical University, Ministry of Health of the Russian Federation</institution></aff><aff><institution xml:lang="ru">Рязанский государственный медицинский университет им. акад. И.П.Павлова Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Acad. I.P.Pavlov Ryazan State Medical University</institution></aff><aff><institution xml:lang="ru">Рязанский государственный медицинский университет им. акад. И.П.Павлова Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-12-19" publication-format="electronic"><day>19</day><month>12</month><year>2016</year></pub-date><volume>15</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>5</fpage><lpage>12</lpage><history><date date-type="received" iso-8601-date="2018-09-19"><day>19</day><month>09</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/127">https://hemoncim.com/jour/article/view/127</self-uri><abstract xml:lang="en"><p>Iron-deficiency anaemia (IDA) has been studied well enough. But in clinical practice there are a number of problems related to diagnosis, treatment and prevention of iron deficiency, resulting in a high incidence of IDA and iron deficiency in Russia. One of the problems remains a choice of a medicinal formulation for oral IDA therapy, namely, a comparative efficacy and safety of ferrous (+2) and ferric (+3) iron preparations. Ferrous iron salts have long and often been used in clinical practice. They have a higher bioavailability. But according to literature data, the possibility of development of adverse events in using ferrous iron salt formulations is often higher than when using ferric iron preparations. Analysis of literature data is demonstrable of an equal efficacy of there two groups of iron drugs in patients with IDA.</p></abstract><trans-abstract xml:lang="ru"><p>Железодефицитная анемия (ЖДА) достаточно хорошо изучена. Однако в клинической практике существует ряд проблем, связанных с диагностикой, лечением и профилактикой дефицита железа, следствием которых является высокая распространенность ЖДА и дефицита железа в России. Одной из проблем остается вопрос выбора лекарственного препарата для пероральной терапии ЖДА, а именно сравнительная эффективность и безопасность препаратов двухи трехвалентного железа. Солевые препараты двухвалентного железа давно и часто используют в клинической практике. Они имеют более высокую биодоступность. Однако, по данным литературы, вероятность развития неблагоприятных явлений при применении солевых препаратов двухвалентного железа часто выше, чем при использовании препаратов трехвалентного железа. Анализ данных литературы свидетельствует о равной эффективности этих двух групп препаратов железа у пациентов с ЖДА.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дефицит железа</kwd><kwd>железодефицитная анемия</kwd><kwd>лечение</kwd><kwd>двухвалентные препараты железа</kwd><kwd>рехвалентные препараты железа</kwd><kwd>эффективность</kwd><kwd>безопасность</kwd><kwd>нежелательные явления</kwd><kwd>iron deficiency</kwd><kwd>iron-deficiency anaemia</kwd><kwd>treatment</kwd><kwd>ferrous iron preparations</kwd><kwd>ferric iron preparations</kwd><kwd>efficacy</kwd><kwd>safety</kwd><kwd>adverse events</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>World Health Organization, World Health Report 2002: Reducing Risks, Promoting Healthy Life. World Health Organization. Geneva, Switzerland, 2002.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Benoist B, McLean E, Egli I, Cogswell M. Worldwide prevalence of anaemia 19932005. WHO Global Database of Anaemia. World Health Organization. Geneva, Switzerland, 2008.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Stevens GA, Finucane MM, De-Regil LM Paciorek CJ, Flaxman SR, Branca F, et al. Global, regional, and national trends in haemoglobin concentration and prevalence of total and severe anaemia in children and pregnant and non-pregnant women for 1995-2011: a systematic analysis of population-representative data. Lancet Glob Health. 2013;1(1):e16-25.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Subramaniam G, Girish M. Iron deficiency anemia in children. Indian J Pediatr. 2015;82(6):558-64.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Eussen S, Alles M, Uijterschout L, Brus F, van der Horst-Graat J. Iron intake and status of children aged 6-36 months in Europe: a systematic review. Ann Nutr Metab. 2015;66(2-3):80-92.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Haas JD, Brownlie T 4th. Iron deficiency and reduced work capacity: a critical review of the research to determine a causal relationship. J Nutr. 2001; 131(2S-2):676S-88S; discussion 688S-90S.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Kozuki N, Lee AC, Katz J; Child Health Epidemiology Reference Group. Moderate to severe, but not mild, maternal anemia is associated with increased risk of small-for-gestational-age outcomes. J Nutr. 2012;142(2):358-62.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Domellöf M. Benefits and harms of iron supplementation in iron-deficient and iron-sufficient children. Nestle Nutr Workshop Ser Pediatr Program. 2010;65:153-62; discussion 162-5.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Iannotti LL, Tielsch JM, Black MM, Black RE. Iron supplementation in early childhood: health benefits and risks. Am J Clin Nutr. 2006;84(6):1261-76.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Lozoff B, Beard J, Connor J Barbara F, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev. 2006; 64(5, Pt 2):S34-43; discussion S72-91.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Walter T. Infancy: mental and motor development. Am J Clin Nutr. 1989;50(3, Suppl):655-61; discussion 661-6.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Agaoglu L, Torun O, Unuvar E, Sefil Y, Demir D. Effects of iron deficiency anemia on cognitive function in children. Arzneimittelforschung. 2007;57(6A):426-30.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Стуклов НИ, Семенова ЕН. Лечение железодефицитной анемии. Что важнее, эффективность или переносимость? Существует ли оптимальное решение? Журнал международной медицины. 2013;1(2):47-55.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Fleming RE, Bacon BR. Orchestration of iron homeostasis. N Engl J Med. 2005;352(17):1741-4.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Громова ОА, Торшин ИЮ, Хаджидис АК. Анализ молекулярных механизмов воздействия железа (II), меди, марганца в патогенезе железодефицитной анемии. Клиническая фармакология и фармакоэкономика. 2010;1:1-9.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Harju E. Clinical pharmacokinetics of iron preparations. Clin Pharmacokinet. 1989;17(2):69-89.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Santiago P. Ferrous versus ferric oral iron formulations for the treatment of iron deficiency: a clinical overview. Scientific World J. 2012;2012:846824.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Schümann K, Classen HG, Hages M, Prinz-Langenohl R, Pietrzik K, Biesalski HK. Bioavailability of oral vitamins, minerals, and trace elements in perspective. Arzneimittelforschung. 1997;47(4):369-80.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Geisser P, Burckhardt S. The pharmacokinetics and pharmacodynamics of iron preparations. Pharmaceutics. 2011;3(1):12-33.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Brock C, Curry H, Hanna C, Knipfer M, Taylor L. Adverse effects of iron supplementation: a comparative trial of a wax-matrix iron preparation and conventional ferrous sulfate tablets. Clin Ther. 1985;7(5):568-73.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Kautz L, Jung G, Valore EV, Rivella S, Nemeth E, Ganz T. Identification of erythroferrone as an erythroid regulator of iron metabolism. Nat Genet. 2014;46(7):678-84.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Nagpal J, Choudhury P. Iron formulations in pediatric practice. Indian Pediatr. 2004;41(8):807-15.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Nielsen P, Gabbe EE, Fischer R, Heinrich HC. Bioavailability of iron from oral ferric polymaltose in humans. Arzneimittelforschung. 1994;44(6):743-8.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Geisser P, Müller A. Pharmacokinetics of iron salts and ferric hydroxide-carbohydrate complexes. Arzneimittelforschung. 1987;37(1A):100-4.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Jacobs P, Wormald LA, Gregory MC. Absorption of iron polymaltose and ferrous sulphate in rats and humans. A comparative study. S Afr Med J. 1979;55(26):1065-72.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Jacobs P, Wood L, Bird AR. Erythrocytes: better tolerance of iron polymaltose complex compared with ferrous sulphate in the treatment of anaemia. Hematology. 2000;5(1):77-83.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Jacobs P, Fransman D, Coghlan P. Comparative bioavailability of ferric polymaltose and ferrous sulphate in iron-deficient blood donors. J Clin Apher. 1993;8(2):89-95.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Jacobs P, Johnson G, Wood L. Oral iron therapy in human subjects, comparative absorption between ferrous salts and iron polymaltose. J Med. 1984;15(5-6):367-77.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Langstaff RJ, Geisser P, Heil WG, Bowdler JM. Treatment of iron-deficiency anaemia: a lower incidence of adverse effects with Ferrum Hausmann than ferrous sulphate. Br J Clin Res. 1993;4:191-8.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Saha L, Pandhi P, Gopalan S, Malhotra S, Saha PK. Comparison of efficacy, tolerability, and cost of iron polymaltose complex with ferrous sulphate in the treatment of iron deficiency anemia in pregnant women. Med Gen Med. 2007;9(1):1.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Murahovschi J, Stein ML, Caraffa RC, Cesar R, et al. Treatment of iron deficiency and iron deficiency anaemia with an iron hydroxide polymaltose complex given orally in children recovering from respiratory infections. Double blind trial, compared with ferrous sulphate. Revista Paulista de Pediatria. 1987;5:97-104.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Jaber L, Rigler S, Taya A, Tebi F, Baloum M, Yaniv I, et al. Iron polymaltose versus ferrous gluconate in the prevention of iron deficiency anemia of infancy. J Pediatr Hematol Oncol. 2010;32(8):585-8.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Kaltwasser JP, Werner E, Niechzial M. Bioavailability and therapeutic efficacy of bivalent and trivalent iron preparations. Arzneimittelforschung. 1987;37(1A):122-9.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Andrade JVD, Rodrigues PPB, Fontura IB, D’Agnoluzzo R, Horta VF, Alves JGB. Tratamento da anemia ferropriva com hidroxido de ferro polimatosado. Arquivos Brasileiros de Medicina. 1992;66:253-8.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Schmidt BJ, Morais MB, Fisberg M, Martins A, Machado NL. Therapeutic comparison between ferrous sulphate and trivalent iron in the form of a polymaltosed ferric hydroxide complex in organic iron deficiency. Folha Med. 1985;90:25-9.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Sözmen EY, Kavakli K, Qetinkaya B, Akgay YD, Yilmaz D, Aydinok Y. Effects of iron(II) salts and iron(III) complexes on trace element status in children with iron-deficiency anemia. Biol Trace Elem Res. 2003;94(1):79-86.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Haliotis FA, Papanastasiou DA. Comparative study of tolerability and efficacy of iron protein succinylate versus iron hydroxide polymaltose complex in the treatment of iron deficiency in children. Int J Clin Pharmacol Ther. 1998;36(6):320-5.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Yasa B, Agaoglu L, Unuvar E. Efficacy, tolerability, and acceptability of iron hydroxide polymaltose complex versus ferrous sulfate: a randomized trial in pediatric patients with iron deficiency anemia. Int J Pediatr. 2011; 2011:524520.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Tuomainen TP, Nyyssönen K, Porkkala-Sarataho E, Salonen R, Baumgartner JA, Geisser P, et al. Oral supplementation with ferrous sulfate but not with nonionic iron polymaltose complex increases the susceptibility of plasma lipoproteins to oxidation. Nutrition Research. 1999;19(8):1121-32.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Hutchinson C, Al-Ashgar W, Liu DY, Hider RC, Powell JJ, Geissler CA. Oral ferrous sulphate leads to a marked increase in pro-oxidant nontransferrin-bound iron. Eur J Clin Invest. 2004;34(11):782-4.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Colak E. New markers of oxidative damage to macromolecules. JMB. 2008;27(1): 1-16.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Dalle-Donne I, Rossi R, Colombo R, Giustarini D, Milzani A. Biomarkers of oxidative damage in human disease. Clin Chem. 2006;52(4):601-23.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Dalle-Donnea I, Rossi R, Giustarini D, Milzani A, Colombo R. Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta. 2003;329(1-2):23-8.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Hawkins CL, Morgan PE, Davies MJ. Quantification of protein modification by oxidants. Free Radic Biol Med. 2009;46(8):965-88.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Garcia-Garcia A, Rodriguez-Rocha H, Madayiputhiya N, Pappa A, Panayiotidis MI, Franco R. Biomarkers of protein oxidation in human disease. Curr Mol Med. 2012;12(6):681-97.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz AG, et al. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 1990;186:464-78.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Фомина МА, Абаленихина ЮВ. Способ комплексной оценки содержания продуктов окислительной модификации белков в тканях и биологических жидкостях: методические рекомендации. ГБОУ ВПО РязГМУ Минздрава России. Рязань: РИО РязГМУ, 2014;36-9.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Левина АА, Казюкова ТВ, Цветаева НВ, Сергеева АИ, Мамукова ЮЛ, Романова ЕА и др. Гепсидин как регулятор гомеостаза железа. Педиатрия. Журнал им. Г.Н.Сперанского. 2008;87(1):67-74.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Ortiz R, Toblli JE, Romero JD, Monterrosa B, Frer C, Macagno E, et al. Efficacy and safety of oral iron(III) polymaltose complex versus ferrous sulfate in pregnant women with iron-deficiency anemia: a multicenter, randomized, controlled study. J Matern Fetal Neonatal Med. 2011;24(11):1347-52.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Oral iron for Anemia: a review of the clinical effectiveness, cost-effectiveness and guidelines. Rapid response report. Summary with critical appraisal. Canadian Agency for Drugs and Technologies in Health. Available at: https://www.ncbi.nlm. nih.gov/pubmedhealth/PMH0084957/pdf/PubMedHealth_PMH0084957.pdf.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Лебедев ВВ, Абаленихина ЮВ, Демихов ВГ, Дмитриев АВ, Фомина МА. Влияние пероральной ферротерапии на процесс окислительной модификации белков у детей с железодефицитной анемией. Материалы Международной конференции IT + M&amp;Ec'2016 «Информационные технологии в медицине, биологии, фармакологии и экологии». Под ред. Глориозова ЕЛ. Гурзуф, 2-12 июня 2016 г. Весенняя сессия. М.: ООО «Институт новых информационных технологий», 2016;180-6.</mixed-citation></ref></ref-list></back></article>
