Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children13210.24287/1726-1708-2016-15-4-42-50ЛЕЙКОЗЫB- and T-cell V(D)J-recombination excision circles as indicators of immunological reconstitution in children with acute lymphoblastic leukemiaЭксцизионные кольца V(D)J рекомбинации B- и T-клеток как показатели иммунологической реконституции у детей с острым лимфобластным лейкозомObraztsovIgor V.ОбразцовИгорь Владимирович
Russian Federation
igor_obraztsov@yahoo.comGordukovaMaria A.ГордуковаМария Александровна
Russian Federation
dgkb9@zdrav.mos.ruTsvetkovaEkaterina V.ЦветковаЕкатерина Вадимовна
Russian Federation
info@fnkc.ruKononovaElena V.КононоваЕлена Владиславовна
Russian Federation
cclibr@cardio.ruTomilinIvan Ya.ТомилинИван Яковлевич
Russian Federation
itomilin@yandex.ruKondratchikKonstantin L.КондратчикКонстантин Леонидович
Russian Federation
KarelinAleksandr F.КарелинАлександр Федорович
Russian Federation
info@fnkc.ruProdeusAndrey P.ПродеусАндрей Петрович
Russian Federation
dgkb9@zdrav.mos.ruKarachunskiyAleksandr I.КарачунскийАлександр Исаакович
Russian Federation
alexandr.karachunski@fccho-moscow.ruRumyantsevAlexandr G.РумянцевАлександр Григорьевич
Russian Federation
Alexander.Rumyantsev@fccho-moscow.ruDmitry Rogachev Federal Research Centre of Paediatric Haematology, Oncology and Immunology, Ministry of Health of the Russian FederationФедеральный научно-клинический центр детской гематологии, онкологии, иммунологии им. Дмитрия Рогачева Минздрава РоссииA.N.Ryzhykh State Research Centre of Coloproctology, Ministry of Health of the Russian FederationГосударственный научный центр колопроктологии им. А.Н.Рыжих Минздрава РоссииG.N.Speransky Children’s City Clinical Hospital No 9, Moscow Department of HealthДетская городская клиническая больница №9 им. Г.Н.Сперанского Департамента здравоохранения г. МосквыRussian Cardiology Research and Production Complex, Ministry of Health of the Russian FederationРоссийский кардиологический научно-производственный комплекс Минздрава РоссииMorozov City Children’s Clinical Hospital, Moscow Department of HealthМорозовская Детская городская клиническая больница Департамента здравоохранения г. МосквыDmitry Rogachev Federal Research Centre of Paediatric Haematology, Oncology and Immunology, Ministry of Health of the Russian FederationФедеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России19122016154425019092018Copyright ©; 2016, «D. Rogachev NMRCPHOI»Copyright ©; 2016, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2016«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/132

Acute lymphoblastic leukemia (ALL) is the most common malignant haematological disease of childhood. ALL is associated with the development of an immune defect, promoting development of both serious infectious complications at the initial stage of therapy and long-term persistent infections in patients during remission. The work studied naîve T and B cells in 49 children in the first acute period of ALL and 55 convalescent children at different terms of remission based on detection of T-cell receptor (TRECs) and K-deleting element (KRECs) excision circles by real-time PCR. As has been shown, development of ALL itself does not lead to suppression of naîve T- and B cell maturation. Specific therapy promotes development of a deep defect of both T and B cell immunity, deficit of naîve T cells persisting for not less than three years after statement of remission, whereas maturation of В cells is restored after termination of the intensive phase of therapy. Also, the inexpediency of using high dosages of methotrexate and cranial irradiation from the viewpoint of long-term immune reconstitution has been confirmed.

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