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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">152</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2016-15-1-72-80</article-id><article-categories><subj-group subj-group-type="toc-heading"><subject>ИММУНОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">TCRaß+ and CD19+ depletion in unrelated and haploidentical hematopoietic stem cell transplantation in children with primary immunodeficiencies</article-title><trans-title-group xml:lang="ru"><trans-title>Опыт применения TCRaß+ и CD19+ деплеции при неродственных и гаплоидентичных трансплантациях гемопоэтических стволовых клеток у детей с первичными иммунодефицитными состояниями</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Laberko</surname><given-names>Alexandra L.</given-names></name><name xml:lang="ru"><surname>Лаберко</surname><given-names>Александра Леонидовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>alexandra-lab@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Maschan</surname><given-names>Michael A.</given-names></name><name xml:lang="ru"><surname>Масчан</surname><given-names>Михаил Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>mmaschan@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shelikhova</surname><given-names>Larissa N.</given-names></name><name xml:lang="ru"><surname>Шелихова</surname><given-names>Лариса Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>lshelihova@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Skvortsova</surname><given-names>Yuliya V.</given-names></name><name xml:lang="ru"><surname>Скворцова</surname><given-names>Юлия Валерьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>yuscvo@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shipitsyna</surname><given-names>Irina P.</given-names></name><name xml:lang="ru"><surname>Шипицына</surname><given-names>Ирина Павловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>ishipitsina@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gutovskaya</surname><given-names>Elena I.</given-names></name><name xml:lang="ru"><surname>Гутовская</surname><given-names>Елена Игоревна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>egutovskaya@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Smirnova</surname><given-names>Irina N.</given-names></name><name xml:lang="ru"><surname>Смирнова</surname><given-names>Ирина Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>sapf_ira@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rodina</surname><given-names>Yuliya A.</given-names></name><name xml:lang="ru"><surname>Родина</surname><given-names>Юлия Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>rodina.julija@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Deripapa</surname><given-names>Elena V.</given-names></name><name xml:lang="ru"><surname>Дерипапа</surname><given-names>Елена Васильевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>deripapa@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dibirova</surname><given-names>Suna A.</given-names></name><name xml:lang="ru"><surname>Дибирова</surname><given-names>Суна Абдурагимовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>suna06@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khamin</surname><given-names>Igor G.</given-names></name><name xml:lang="ru"><surname>Хамин</surname><given-names>Игорь Геннадьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>igorchamin@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Novichkova</surname><given-names>Galina A.</given-names></name><name xml:lang="ru"><surname>Новичкова</surname><given-names>Галина Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>Galina.Novichkova@fccho-moscow.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Maschan</surname><given-names>Alexei A.</given-names></name><name xml:lang="ru"><surname>Масчан</surname><given-names>Алексей Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>amaschan@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shcherbina</surname><given-names>Anna Yu.</given-names></name><name xml:lang="ru"><surname>Щербина</surname><given-names>Анна Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>shcher26@hotmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Balashov</surname><given-names>Dmitry N.</given-names></name><name xml:lang="ru"><surname>Балашов</surname><given-names>Дмитрий Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>bala8@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Federal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev</institution></aff><aff><institution xml:lang="ru">Федеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-03-19" publication-format="electronic"><day>19</day><month>03</month><year>2016</year></pub-date><volume>15</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>72</fpage><lpage>80</lpage><history><date date-type="received" iso-8601-date="2018-09-19"><day>19</day><month>09</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/152">https://hemoncim.com/jour/article/view/152</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>первичные иммунодефицитные состояния</kwd><kwd>трансплантация гемопоэтических стволовых клеток</kwd><kwd>TCRaß+/CD19+ деплеция</kwd><kwd>реакция «трансплантат против хозяина»</kwd><kwd>children</kwd><kwd>primary immunodeficiencies</kwd><kwd>hematopoietic stem cell transplantation</kwd><kwd>TCRaß+/CD19+ depletion</kwd><kwd>graft-versus-host disease</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Fischer A. Human primary immunodeficiency diseases. Immunity. 2007; 27(6): 835-45.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Gatti RA, Meuwissen HJ, Allen HD, Hong R, Good RA. Immunological reconstitution of sex-linked lymphopenic immunological deficiency. Lancet. 1968; 2(7583): 1366-9.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Bach FH, Albertini RJ, Joo P, Anderson JL, Bortin MM. Bone-marrow transplantation in a patient with the Wiskott-Aldrich syndrome. Lancet. 1968; 2(7583): 1364-6.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Gennery AR, Slatter MA, Grandin L, Taupin P, Cant AJ, Veys P, et al. Transplantation of hematopoietic stem cells and long-term survival for primary immunodeficiencies in Europe: entering a new century, do we do better? J Allergy Clin Immunol. 2010; 126(3): 602-10.e1-11.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Pai SY, Notarangelo LD. Hematopoietic cell transplantation for Wiskott-Aldrich syndrome: advances in biology and future directions for treatment. Immunol Allergy Clin North Am. 2010; 30(2): 179-94.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Booth C, Gilmour KC, Veys P, Gennery AR, Slatter MA, Chapel, H et al. X-linked lymphoproliferative disease due to SAP/SH2D1A deficiency: a multicenter study on the manifestations, management and outcome of the disease. Blood. 2011; 117(1): 53-62.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Chakrabarti S, Milligan DW, Brown J, Osman H, Vipond IB, Pamphilon DH, et al. Influence of cytomegalovirus (CMV) sero-positivity on CMV infection, lymphocyte recovery and non-CMV infections following T-cell-depleted allogeneic stem cell transplantation: a comparison between two T-cell depletion regimens. Bone Marrow Transplant. 2004; 33(2): 197-204.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Bacigalupo A, Mordini N, Pitto A, Piaggio G, Podestà M, Benvenuto F, et al. Transplantation of HLA-mismatched CD34+ selected cells in patients with advanced malignancies: severe immunodeficiency and related complications. Br J Haematol. 1997; 98(3): 760-6.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Aversa F, Tabilio A, Velardi A, Cunningham I, Terenzi A, Falzetti F, et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med. 1998; 339(17): 1186-93.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Bertaina A, Merli P, Rutella S, Pagliara D, Bernardo ME, Masetti R, et al. HLA-haploidentical stem cell transplantation after removal of aß+ T and B cells in children with nonmalignant disorders. Blood. 2014; 124(5): 822-6.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Airoldi I, Bertaina A, Prigione I, Zorzoli A, Pagliara D, Cocco C, et al. γδ T-cell reconstitution after HLA-haploidentical hematopoietic transplantation depleted of TCR-aß+/CD19+ lymphocytes. Blood. 2015; 125(15): 2349-58.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Balashov D, Shcherbina A, Maschan M, Trakhtman P, Skvortsova Y, Shelikhova L, et al. Single-center experience of unrelated and haploidentical stem cell transplantation with TCRaß and CD19 depletion in children with primary immunodeficiency syndromes. Biol Blood Marrow Transplant. 2015; 21(11): 1955-62.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Vantourout P, Hayday A. Six-of-the-best: unique contributions of γδ T cells to immunology. Nat Rev Immunol. 2013; 13(2): 88-100.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Bekiaris V, Šedy JR, Ware CF. Mixing signals: molecular turn ons and turn offs for innate γδ T-cells. Front Immunol. 2014; 5: 654.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Curtis RE, Travis LB, Rowlings PA, Socié G, Kingma DW, Banks PM, et al. Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study. Blood. 1999; 94(7): 2208-16.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Chiang KY, Hazlett LJ, Godder KT, Abhyankar SH, Christiansen NP, van Rhee F, et al. Epstein-Barr virus-associated B cell lymphoproliferative disorder following mismatched related T cell-depleted bone marrow transplantation. Bone Marrow Transplant. 2001; 28(12): 1117-23.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Lang P, Teltschik HM, Feuchtinger T, Müller I, Pfeiffer M, Schumm M, et al. Transplantation of CD3/CD19 depleted allografts from haploidentical family donors in paediatric leukaemia. Br J Haematol. 2014; 165(5): 688-98.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Przepiorka D, Weisdorf D, Martin P, Klingemann HG, Beatty P, Hows J, et al. 1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant. 1995; 15(6): 825-8.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Grunebaum E, Mazzolari E, Porta F, Dallera D, Atkinson A, Reid B, et al. Bone marrow transplantation for severe combined immune deficiency. JAMA. 2006: 295(5): 508-18.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Slatter M, Nademi Z, Patel S, Barge D, Valappil M, Brigham K, et al. Haploidentical hematopoietic stem cell transplantation can lead to viral clearance in severe combined immunodeficiency. J Allergy Clin Immunol. 2013; 131(6): 1705-8.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Dvorak CC, Hassan A, Slatter MA, Hönig M, Lankester AC, Buckley RH, et al. Comparison of outcomes of hematopoietic stem cell transplantation without chemotherapy conditioning by using matched sibling and unrelated donors for treatment of severe combined immunodeficiency. J Allergy Clin Immunol. 2014; 134(4): 935-43.e15.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Балашов ДН. Факторы риска и контроль вирусных инфекций после трансплантации гемопоэтических стволовых клеток. Автореф. дисс.. докт. мед. наук. М., 2011. / Balashov DN. Faktory riska i kontrol' virusnykh infektsii posle transplantatsii gemopoeticheskikh stvolovykh kletok. Avtoref. diss. dokt. med. nauk. Moscow, 2011. (In Russian).</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Laberko A, Maschan M, Shelikhova L, Balashov D, Skvortsova J, Boyakova E, et al. Analysis of risk factors of viral reactivation after haploidentical and matched unrelated hematopoietic stem cell transplantation with TCR alpha/beta and CD19 depletion. Bone Marrow Transplant. 2015; 50(Suppl. 1): S187-8. (41st Annual Meeting of the European Society for Blood and Marrow Transplantation, March, 22-25, 2015, Istanbul, Turkey).</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Hiwarkar P, Gajdosova E, Qasim W, Worth A, Breuer J, Chiesa R, et al. Frequent occurrence of cytomegalovirus retinitis during immune reconstitution warrants regular ophthalmic screening in high-risk pediatric allogeneic hematopoietic stem cell transplant recipients. Clin Infect Dis. 2014; 58(12): 1700-6.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Cantoni N, Hirsch HH, Khanna N, Gerull S, Buser A, Bucher C, et al. Evidence for a bidirectional relationship between cytomegalovirus replication and acute graft-versus-host disease. Biol Blood Marrow Transplant. 2010; 16(9): 1309-14.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Handgretinger R. Negative depletion of CD3(+) and TcRaß(+) T cells. Curr Opin Hematol. 2012; 19(6): 434-9.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Amrolia P, Gaspar HB, Hassan A, Webb D, Jones A, Sturt N, et al. Nonmyeloablative stem cell transplantation for congenital immunodeficiencies. Blood. 2000; 96(4): 1239-46.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Rao K, Amrolia PJ, Jones A, Cale CM, Naik P, King D, et al. Improved survival after unrelated donor bone marrow transplantation in children with primary immunodeficiency using a reduced-intensity conditioning regimen. Blood. 2005: 105(2): 879-85.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Oshrine BR, Olson TS, Bunin N. Mixed chimerism and graft loss in pediatric recipients of an alemtuzumab-based reduced-intensity conditioning regimen for non-malignant disease. Pediatr Blood Cancer. 2014; 61(10): 1852-9.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Shaw BE, Byrne JL, Das-Gupta E, Carter GI, Russell NH. The impact of chimerism patterns and predonor leukocyte infusion lymphopenia on survival following T cell-depleted reduced intensity conditioned transplants. Biol Blood Marrow Transplant. 2007; 13(5): 550-9.</mixed-citation></ref></ref-list></back></article>
