Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children15810.24287/1726-1708-2016-15-2-27-31СтатьиPathogen inactivation technologies and quality of platelet concentrates (Review of literature)Технологии инактивации патогенов и качество концентратов тромбоцитов (обзор литературы)IgnatovaAnastasia A.ИгнатоваАнастасия Александровна
Russian Federation
procyonnlotor@gmail.comTrakhtmanPavel E.ТрахтманПавел Евгеньевич
Russian Federation
trakhtman@mail.ruPanteleevMikhail A.ПантелеевМихаил Александрович
Russian Federation
mapanteleev@yandex.ruFederal Research Center of Pediatric Hematology, Oncology and Immunology named after Dmitry Rogachev, Ministry of Health of the Russian FederationФедеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России19062016152273119092018Copyright ©; 2016, «D. Rogachev NMRCPHOI»Copyright ©; 2016, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2016«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/158

Platelet concentrate (PC) transfusion is practically the only fast and universal way of correcting platelet function in a broad range of clinical situations in paediatric haematology. Due to a short storage time of PC, technologies of pathogen inactivation are very important for decreasing the risks of immune responses and infections. There are numerous studies indicating that platelet function can change in pathogen inactivation. The article offers a literature review of laboratory and clinical studies aimed at assessment of the significance and direction of these changes, and also discusses practical implications of such studies for clinical work with PC.

Переливание концентратов тромбоцитов (КТ) является практически единственным быстрым и универсальным способом коррекции тромбоцитарной функции при широком спектре клинических ситуаций в детской гематологии. В силу короткого срока хранения КТ технологии инактивации патогенов крайне важны для снижения рисков иммунных реакций и инфекций. Однако существует большое количество исследований, свидетельствующих о том, что функция тромбоцитов при инактивации патогенов может меняться. В обзоре литературы рассмотрены лабораторные и клинические исследования, направленные на оценку значимости и направленности этих изменений, а также обсуждено практическое значение этих исследований для клинической работы с КТ.

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