Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children17310.24287/1726-1708-2018-17-2-28-38ORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИLate effects after treosulfan- and busulfan-based myeloablative conditioning for allogeneic HSCT in children with malignant diseases: a comparative studyСравнительная оценка влияния треосульфан- и бусульфан-содержащих миелоаблативных режимов кондиционирования на поздние осложнения аллогенных ТГСК при злокачественных заболеваниях у детейhttps://orcid.org/0000-0002-0566-053XSkvortsovaY. V.СкворцоваЮ. В.
Russian Federation

MD, hematologist, Hematopoietic Stem Cell Transplantation Department

Russia 117997, Moscow, Samory Mashela st., 1

yuscvo@mail.ruhttps://orcid.org/0000-0002-2322-5734NovichkovaG. A.НовичковаГ.А.
Russian Federation
https://orcid.org/0000-0003-1735-0093MaschanM. A.МасчанМ.А.
Russian Federation
https://orcid.org/0000-0003-2689-0569BalashovD. N.БалашовД.Н.
Russian Federation
https://orcid.org/0000-0001-7750-5216PapushaL. I.ПапушаЛ.И.
Russian Federation
https://orcid.org/0000-0001-8687-5497ShipitsinaI. P.ШипицынаИ.П.
Russian Federation
https://orcid.org/0000-0003-0520-5630ShelikhovaL. N.ШелиховаЛ.Н.
Russian Federation
https://orcid.org/0000-0001-7578-9657VoroninK. A.ВоронинК.А.
Russian Federation
https://orcid.org/0000-0003-4431-1444SkorobogatovaE. V.СкоробогатоваЕ.В.
Russian Federation
https://orcid.org/0000-0002-0016-6698MaschanA. A.МасчанА.А.
Russian Federation
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, ImmunologyФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииФГБУ «Российская детская клиническая больница» Минздрава России20092018172283820092018Copyright ©; 1970, «D. Rogachev NMRCPHOI»Copyright ©; 1970, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России1970«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/173

Treosulfan-based regimens used in conditioning for allogeneic HSCT (allo-HSCT) in children allow to reduce incidence of transplant-related mortality and early toxicity, but there are no data about long-term effects. We propose a retrospective comparative study of late complications after allo-HSCT in 135 children with hematologic malignancies, who got allo-HSCT between January 1994 and July 2011 and survived at least 1 year after HSCT. Five-year event free survival was 75.6% in the group of children who got busulfan and 66.5% in patients with treosulfan-based conditioning; 5-year nonrelapse mortality was 6% and 10.2%, respectively. Late effects analysis demonstrated that treosulfan-containing conditioning allowed to reduce the incidence of some late complications: hypergonadotropic hypogonadism cumulative incidence was 0 compared to 32.8% in busulfan-conditioning group (р = 0.012); the decrease in subclinical hypothyroidism, secondary cardiomyopathy and organic central nervous system pathology incidence was revealed. Thus treosulfan-based conditioning regimen is an effective approach in reducing of serious late complications after allogeneic HSCT when compared with data of busulfan-based conditioning long-term effects.

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