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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">174</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2018-17-2-39-50</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">The Influence of Natural Killer Cell Alloreactivity on the Outcome of α/βTCR/CD19+ depleted Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients with Acute Leukemia</article-title><trans-title-group xml:lang="ru"><trans-title>Влияние аллореактивности естественных киллерных клеток на эффективность аллогенной трансплантации гемопоэтических стволовых клеток с деплецией альфа/бетаTCR/CD19+ лимфоцитов у педиатрических пациентов с острыми лейкозами</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5949-5317</contrib-id><name-alternatives><name xml:lang="en"><surname>Zakharova</surname><given-names>V. V.</given-names></name><name xml:lang="ru"><surname>Захарова</surname><given-names>В.В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Molecular Biology Laboratory</p><p>Moscow, 117997, 1 Samori Mashela str.</p><p>(495) 287-65-70, add. 5533</p></bio><email>hla.dgoi@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9912-6572</contrib-id><name-alternatives><name xml:lang="en"><surname>Shekhovtsova</surname><given-names>Z. B.</given-names></name><name xml:lang="ru"><surname>Шеховцова</surname><given-names>Ж.Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1547-4212</contrib-id><name-alternatives><name xml:lang="en"><surname>Shragina</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Шрагина</surname><given-names>О.А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7634-2053</contrib-id><name-alternatives><name xml:lang="en"><surname>Raykina</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Райкина</surname><given-names>Е.В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7652-7704</contrib-id><name-alternatives><name xml:lang="en"><surname>Ilushina</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Илюшина</surname><given-names>М.А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3513-8299</contrib-id><name-alternatives><name xml:lang="en"><surname>Muzalevskii</surname><given-names>Y. O.</given-names></name><name xml:lang="ru"><surname>Музалевский</surname><given-names>Я.О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3632-291X</contrib-id><name-alternatives><name xml:lang="en"><surname>Kochetov</surname><given-names>A. G.</given-names></name><name xml:lang="ru"><surname>Кочетов</surname><given-names>А.Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0520-5630</contrib-id><name-alternatives><name xml:lang="en"><surname>Shelikhova</surname><given-names>L. N.</given-names></name><name xml:lang="ru"><surname>Шелихова</surname><given-names>Л.Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1735-0093</contrib-id><name-alternatives><name xml:lang="en"><surname>Maschan</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Масчан</surname><given-names>М.А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Institute of Cardiology of National Medical Research Center for Cardiology</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр кардиологии» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-09-20" publication-format="electronic"><day>20</day><month>09</month><year>2018</year></pub-date><volume>17</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>39</fpage><lpage>50</lpage><history><date date-type="received" iso-8601-date="2018-09-20"><day>20</day><month>09</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1970, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1970, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>1970</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/174">https://hemoncim.com/jour/article/view/174</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>killer cell immunoglobulin-like receptors</kwd><kwd>KIR genes</kwd><kwd>hematopoietic stem cell transplantation</kwd><kwd>donor</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>иммуноглобулиноподобные рецепторы киллерных клеток</kwd><kwd>KIR-гены</kwd><kwd>трансплантация гемопоэтических стволовых клеток</kwd><kwd>донор</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>McQueen K.L., Parham P. Variable receptors controlling activation and inhibition of NK cells. Current opinion in Immunology 2002; 14: 615-21.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Mandelboim O., Reyburn H.T., Vales-Gomez M., et al. Protection from lysis by natural killer cell of group 1 and 2 specificity is mediated by residue 80 in human Histocompatibility Leukocyte Antigen C alleles and also occurs with empty Major Histocompatibility Complex molecules. The Journal of Experimental Medicine 1996; 184: 913-22.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Thananchai H., Gillespie G., Martin M.P., et al. Cutting edge: allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. The Journal of Immunol 2007; 178: 33-7.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Ljunggren H.G., Karre K. In search of the «missing self»: MHC molecules and NK cell recognition. Immunology today 1990; 11: 237-44.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Rugerri L., Capanni M., Casucci M., Volpi I., et al. Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood 1999; 94: 333-9.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Uhrberg M., Valiante N.M., Shum B.P., et al. Human diversity in killer cell inhibitory receptor genes. Immunity 1997; 7: 753-63.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Witt C.S., Dewing C.B., Sayer D.C., et al. Population frequencies and putative haplotypes of the killer cell immunoglobulin-like receptor sequences and evidence for recombination. Transplantation 1999; 68: 1784-89.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Mehra N.K., Kaur G., McCluskey J., et al. The HLA complex in Biology and Medicine: A Resource Book 2010; 31: 526-27.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Savani B.N., Mielke S., Adams S., Uribe M., et al. Rapid natural killer cell recovery determines outcome after T-cell-depleted HLA-identical stem cell transplantation in patients with myeloid leukemias but not with acute lymphoblastic leukemia. Leukemia 2007; 21: 2145-52.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Maschan M., Shelikhova L., Ilushina M., et al. TCR-alpha/beta and CD19 depletion and threosulfan-based conditioning regimen in unrelated and haploidentical transplantation in children with acute myeloid leukemia. Bone Marrow Transplant 2016; 51 (5): 668-74.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Balashov D., Shcherbina A., Maschan M., et. al. Single-center experience of unrelated and haploidentical stem cell transplantation with TCR and CD19 depletion in children with primary immunodeficiency syndromes. Biol Blood Marrow Transplant 2015; 21 (11): 1955-62.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Laberko A., Bogoyavlenskaya A., Shelikhova L., et. al. Risk Factors and the Clinical impact of Cytomegalovirus and Epstein-Barr Virus infections in Pediatric Recipients of TCR and CD19-Depleted Grafts. Biol Blood Marrow Transplant 2017; 23 (3): 483-90.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Balashov D., Laberko A., Shcherbina A., et. al. A Conditioning Regimen with Plerixafor is Safe and Improves the Outcome of TCR and CD19+-Cell-Depleted Stem Cell Transplantation in Patients with Wiskott-Aldrich Syndrome. Biol Blood Marrow Transplant 2018;(18): 30119-8.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>http://hla.alleles.org/dictionary/index.html</mixed-citation></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">Biassoni R., Vanni I., Ugolotti E. Killerimmunoglobulin-like receptors and their ligands. Histocompatibility book 2012; 6: 97-9.</mixed-citation><mixed-citation xml:lang="ru">Biassoni R., Vanni I., Ugolotti E. Killerimmunoglobulin-like receptors and their ligands. Histocompatibility book 2012; 6: 97-9.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><mixed-citation>http://www.ebi.ac.uk/ipd/kir</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Cooley S., Weisdorf D.J., Guethlein L.A., et al. Donor selection for natural killer receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia. Blood 2010; 116: 2411-19.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Rajalingham R. Overview of the killer cell immunoglobulin-like receptor sys-tem. Methods in Molecular Biology Book 2012; 882: 391-414.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Oevermann L., Michaelis S.U., Mezger M., Lang P., et al. KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL. Blood 2014; 124: 2744-7.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Torelli G.F., Peragine N., Raponi S., et al. Recognition of adult and pediatric acute lymphoblastic leukemia blasts by natural killer cells. Haematologica 2014; 99: 1248-54.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Yabe T., Matsuo K., Hirayasu K., et al. Donor killer immunoglobulin-like receptor genotype-patient cognate KIR ligand combination and antithymocyte globulin preadministration are critical factors in outcome of HLA-C-KIR ligand-mismatched T-cell-replete unrelated bone marrow transplantation. Biol Blood Marrow Transplant 2008; 14: 75-87.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Cooley S., McCullar V., Wangen R., et al. KIR reconstitution is altered by T-cells in the graft and correlates with clinical outcomes after unrelated donor transplantation. Blood 2005; 106: 4370-76.</mixed-citation></ref></ref-list></back></article>
