Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children17910.24287/1726-1708-2018-17-2-84-91ORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИSubsequent gliomas in survivors of paediatric neoplasmsЗлокачественные глиомы, последовавшие за лечением новообразований у детейShatsL. I.ШацЛ.И.
Russian Federation

paediatric oncologist Division of Oncology, Paediatric Oncology and Radiotherapy, Division of Oncology

Russia 194353, St. Petersburg, Litovskaya str., 2Tel.: +7 (921) 751-3882

mila.shats@gmail.comBelogurovaM. B.БелогуроваМ.Б.
Russian Federation
OzerovS. S.ОзеровС.С.
Russian Federation
EktovaA. P.ЭктоваА.П.
Russian Federation
NechesnukA. V.НечеснюкА.В.
Russian Federation
RizhovaM. V.РыжоваМ.В.
Russian Federation
VizhlukovaO. V.ВужлуковаО.В.
Russian Federation
DoroninaI. V.ДоронинаИ.В.
Russian Federation
TsirenovaH. V.ЦыреноваХ.В.
Russian Federation
GrishinaE. V.ГришинаЕ.В.
Russian Federation
ZheludkovaO. G.ЖелудковаО.Г.
Russian Federation
RudnevaA. E.РудневаА.Е.
Russian Federation
PshonkinA. V.ПшонкинА.В.
Russian Federation
EregaE. P.ЕрегаЕ.П.
Russian Federation
KumirovaE. V.КумироваЭ.В.
Russian Federation
Division of Oncology, Saint-Petersburg State Paediatric Medical University St. Petersburg Clinical Research and Practical Center of Specialized Types of Medical Care (Oncologic)ФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава России, ГБУЗ «Санкт-Петербургский клинический научно-практический центр специализированных видов медицинской помощи (онкологический)»Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, ImmunologyФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииN.N. Burdenko Neurosurgical Institute, Russian Academy of Medical SciencesФГАУ «Национальный медицинский исследовательский центр нейрохирургии имени академика Н.Н. Бурденко» Минздрава РоссииPaediatric Hospital of MurmanskГОБУЗ «Мурманская детская клиническая больница»Buryatia Republican Oncology and Haematology Center, Ulan-UdeРеспубликанский гематоонкологический центр Республики Бурятия»Children's Republican Clinical Hospital, KazanГАУЗ «Детская республиканская клиническая больница» Минздрава Республики ТатарстанRussian Scientific Center of RoentgenoradiologyФГБУ «Российский научный центр рентгенорадиологии» Минздрава РоссииФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииChildren's Regional Hospital, KhabarovskКГБУЗ «Детская краевая клиническая больница»Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, ImmunologyФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России20092018172849120092018Copyright ©; 1970, «D. Rogachev NMRCPHOI»Copyright ©; 1970, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России1970«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/179

Multimodal therapy has improved survival for most childhood tumours. The development of neoplasms subsequent to therapeutic cranial irradiation is a rare but serious and potentially fatal complication. The analysis included 16 patients (pts.) with subsequent glioblastoma (SG) from several institutions in Russia who underwent cranial or neck irradiation (1 case) to treat their primary disease (acute lymphoblastic leukaemia – 12 pts., medulloblastoma – 2 pts., choroid plexus papilloma – 1 pts., lymphoma – 1 pts.). All gliomas arose within the previous radiation fields and satisfied the widely used criteria for the definition of radiation induced neoplasms. The median RT dose administered was 18 Gy with the dosage ranges being 12–55 Gy. TBI was used in one patient with Ph-positive ALL during bone marrow transplantation. Median latency period was 6 years until diagnosis of SG. The majority of SG (14 of 16) occurred during the initial 9 years of follow-up. Patients underwent surgery resection followed by standard fractionated local radiation and chemotherapy. A Kaplan–Meier analysis was used to illustrate the overall survival (OS) curves. OS rate was 34.4 ± 12.3% and 13,6 ± 9.0% at 1 and 2 years respectively with median 11 months. In case that paediatric neoplasms are treated by standard fractionated radiation or TBI is used, radiation-induced gliomas should be considered as possible long-term side effect. And the patients should be followed for a long term, even long after the period of risk for relapse of the primary cancer has passed.

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