Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children18810.24287/1726-1708-2018-17-3-28-34ORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИAssociation between congenital heart disease and neuroblastoma in childrenАссоциация врожденных пороков сердца и нейробластомы у детейhttps://orcid.org/0000-0002-3767-4477ShamanskayaT. V.ШаманскаяТ. В.
Russian Federation

Tatyana V. Shamanskaya, MD, scientific secretary

117997, Moscow, Samory Mashela st., 1

Шаманская Татьяна Викторовна, канд. мед. наук, ученый секретарь 

врач-онколог отделения клинической онкологии 

117997, Москва, ГСП-7, ул. Саморы Машела, 1

shamanskaya.tatyana@gmail.comhttps://orcid.org/0000-0002-1925-2457BurgolM. M.БурголМ. М.
Russian Federation
https://orcid.org/0000-0002-3704-8783KachanovD. Yu.КачановД. Ю.
Russian Federation
RybalkoN. A.РыбалкоН. А.
Russian Federation
PankratievaL. L.ПанкратьеваЛ. Л.
Russian Federation
SugakA. B.СугакА. Б.
Russian Federation
FeoktistovaE. V.ФеоктистоваЕ. В.
Russian Federation
VarfolomeevaS. R.ВарфоломееваС. Р.
Russian Federation
Institute of oncology, radiology and nuclear medicineИнститута онкологии, радиологии и ядерной медициныDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России2409201817328342309201823092018Copyright ©; 2018, «D. Rogachev NMRCPHOI»Copyright ©; 2018, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2018«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/188

We have analyzed the association between the most common extracranial solid tumor of childhood neuroblastoma (NB) and congenital heart disease (CHD) based on our own data and literature review. The analyses was carried out based on medical history and  echocardiography data of NB patients, who received medical treatment in Dmitriy Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology. 11 out of 457 patients with NB had CHD, the most common diagnosis was ventricular septal defect. The epidemiologic data of the cohort of patients with CHD and NB was presented. The article contains detailed description of two patients with CHD and localized and metastatic NB. The comprehensive analysis of the existing literature was done. In conclusion, CHD was observed in 2,4% cases. All patients with NB are required cardiologic assessment including echocardiography.

В работе представлен анализ ассоциации наиболее часто встречающейся экстракраниальной солидной опухоли детского возраста – нейробластомы (НБ) и врожденных пороков сердца (ВПС), основанный на собственных и литературных данных. Анализ проведен на основании данных анамнеза и оценки эхокардиографического исследования (ЭХО-КГ) пациентов с установленным диагнозом «НБ», получавших лечение в НМИЦ детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России. У 11 пациентов из 457 больных с НБ выявлен ВПС, наиболее частым из которых был дефект межжелудочковой перегородки. В статье рассмотрены эпидемиологические данные указанной когорты больных. Представлены детальное описание двух клинических случаев сочетания ВПС и локальной и метастатической формы НБ и обзор литературы, посвященной данной тематике. У пациентов с НБ был выявлен ВПС в 2,4% случаев. Все пациенты с НБ нуждаются в кардиологическом обследовании, включающем ЭХО-КГ.

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