Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children21810.24287/1726-1708-2018-17-4-82-99LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫL-asparaginase: new approaches to improve pharmacological characteristicsL-аспарагиназа: новые подходы к улучшению фармакологических свойствhttps://orcid.org/0000-0003-4669-977XBorsakovaD. V.БорсаковаД. В.
Russian Federation

researcher of the Laboratory of Biophysics.

 117997, Moscow, Samory Mashela st., 1. 

мл. научный сотрудник лаборатории биофизики.

 117997, Москва, ГСП-7, ул. Саморы Машела, 1. 

d.borsakova@gmail.comhttps://orcid.org/0000-0002-5948-3444SinauridzeE. I.СинауридзеЕ. И.
Russian Federation
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииCenter for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences.ФГБУН «Центр теоретических проблем физико-химической фармакологии» РАН.1301201917482991201201912012019Copyright ©; 2019, «D. Rogachev NMRCPHOI»Copyright ©; 2019, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2019«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/218

The review focuses on the antitumor L-asparaginase preparation, its properties and mechanism of action, as well as its new drug forms, which possess improved characteristics of efficiency, safety and pharmacokinetics. Particular attention is paid to L-asparaginase included in erythrocytes.

Обзор посвящен противоопухолевому препарату L-аспарагиназе, его свойствам, механизму действия, а также новым лекарственным формам, обладающим улучшенными показателями эффективности, безопасности и фармакокинетики. Особое внимание уделено L-аспарагиназе, включенной в эритроциты.

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