Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children23310.24287/1726-1708-2019-18-1-112-126LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫBCR-ABLl-like pediatric acute lymphoblastic leukemiaBCR-ABLl-подобный острый лимфобластный лейкоз у детейhttps://orcid.org/0000-0002-9881-6221TsaurG. A.ЦаурГ. А.
Russian Federation

Grigory А. Tsaur, MD, Doctor of Medical Science.

620149, Ekaterinburg, S. Deryabina st., 32

Цаур Григорий Анатольевич - доктор медицинских наук, заведующий лабораторией молекулярной биологии, иммуно-фенотипирования и патоморфологии ОДКБ.

620149, Екатеринбург, ул. Серафимы Дерябиной, 32

tsaur@mail.ruhttps://orcid.org/0000-0002-2352-7716OlshanskayaYu. V.ОльшанскаяЮ. В.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0003-1308-8622DruyA. E.ДруйА. Е.
Russian Federation

Moscow

Москва

Regional Children’s HospitalГАУЗ СО Областная детская клиническая больницаResearch Institute of Medical Cell TechnologiesГБОУ ВПО «Уральский государственный медицинский университет» Минздрава РоссииUral State Medical UniversityГБОУ ВПО «Уральский государственный медицинский университет» Минздрава РоссииDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России210420191811121262104201921042019Copyright ©; 2019, «D. Rogachev NMRCPHOI»Copyright ©; 2019, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2019«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/233

The purpose of this study is a comprehensive analysis of BCR-ABLl-like pediatric acute lymphoblastic leukemia (ALL) and to point out the difference between BCR-ABLl-like and Ph-like ALL in children. It was shown the genetic heterogeneity of BCR-ABLl-like ALL including cases with tyrosine kinase fusion genes, activating mutations in JAK-STAT, RAS. We also described various diagnostic options and prognostic role of BCR-ABL1-like ALL in children.

Цель настоящего обзора - характеристика генетических особенностей BCR-ABL1-подобного острого лимфобластного лейкоза (ОЛЛ) у детей, а также устранение терминологической путаницы, связанной с понятиями BCR-ABLl-подобный и Ph-подобный ОЛЛ. Показана генетическая неоднородность BCR-ABL1-подобного ОЛЛ у детей, подробно представлены генетические аномалии, выявляемые у детей c BCR-ABLl-подобным ОЛЛ. Подробно описаны методы диагностики данного типа ОЛЛ, а также прогностическое значение BCR-ABL1-подобного ОЛЛ у детей.

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