Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children24910.24287/1726-1708-2019-18-2-92-102ORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИThe thoracic air-leak syndrome (TALS): the frequency of occurrence and radiological signs in the structure of late non-infectious lung lesions in children after the allogeneic HSСTCиндром торакальной «утечки воздуха»: частота встречаемости и рентгенологическая семиотика в структуре поздних неинфекционных поражений легких у детей после аллогенной ТГКСhttps://orcid.org/0000-0001-7317-7104TereshchenkoG. V.ТерещенкоГ. В.
Russian Federation

Galina V. Tereshchenko, MD, radiologist.

117997, Moscow, Samory Mashela st., 1.

Терещенко Галина Викторовна, канд. мед. наук, врач-рентгенолог, заведующая рентгенологическим отделением.

117997, Москва, ГСП-7, ул. Саморы Машела, 1.

galina.tereshenko@fccho-moscow.ruhttps://orcid.org/0000-0002-9426-0676TernovayaE. S.ТерноваяЕ. С.
Russian Federation
https://orcid.org/0000-0003-0520-5630ShelikhovaL. N.ШелиховаЛ. Н.
Russian Federation
https://orcid.org/0000-0002-0566-053XSkvortsovaYu. V.СкворцоваЮ. В.
Russian Federation
https://orcid.org/0000-0002-7461-0050LitvinovD. V.ЛитвиновД. В.
Russian Federation
https://orcid.org/0000-0002-2322-5734NovichkovaG. A.НовичковаГ. А.
Russian Federation
https://orcid.org/0000-0002-0016-6698MaschanA. A.МасчанА. А.
Russian Federation
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России29062019182921022906201929062019Copyright ©; 2019, «D. Rogachev NMRCPHOI»Copyright ©; 2019, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2019«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/249

The thoracic air-leak syndrome (TALS) can be a presentation of late-onset noninfectious pulmonary complications in children with a chronic pulmonary graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation. We determined the frequency of occurrence of TALS in patients of the Center after HSСT in the period from January 2012 to December 2017. We have described the main X-ray signs of the Thoracic air-leak syndrome and manifestations of late onset noninfectious pulmonary complications in children. The study was approved by the Independent Ethics Committee of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, and Immunology. Parents patients agreed to use personal data in research and publications.

Синдромом торакальной «утечки воздуха» может быть проявлением поздних неинфекционных поражений легких у детей с проявлениями хронической реакции «трансплантат против хозяина» после аллогенной трансплантации гемопоэтических стволовых клеток. Была выявлена частота встречаемости этого синдрома у пациентов Центра после ТГСК в период с января 2012 по декабрь 2017 года. Описаны основные рентгенологические признаки синдрома торакальной утечки воздуха и течения ПНПЛ у детей. Данное исследование поддержано Независимым этическим комитетом и утверждено решением Ученого совета НМИЦ ДГОИ. Родители пациентов дали согласие на использование информации о ребенке в научных исследованиях и публикациях.

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