Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children2510.24287/1726-1708-2018-17-1-37-45СтатьиIntrachromosomal amplification of chromosome 21 (iAMP21) is the marker of unfavorable prognosis in childhood B-cell precursor acute lymphoblastic leukemiaВнутрихромосомная амплификация 21q (iAMP21) как маркер неблагоприятного прогноза при острых лимфобластных лейкозах из В-линейных предшественниковhttps://orcid.org/0000-0002-2352-7716OlshanskayaYu. V.ОльшанскаяЮ.В.
Russian Federation

M.D., Ph.D., Head of laboratory of cytogenetics and molecular genetics

Russia 117997, Moscow, Samory Mashela st., 1+7 (495) 287-6570

yuliaolshanskaya@gmail.comKazakovaA. N.КазаковаА.Н.
Russian Federation
ChervovaA. A.ЧервоваА.А.
Russian Federation
RumiantsevaJ. V.РумянцеваЮ.В.
Russian Federation
https://orcid.org/0000-0002-7461-0050LitvinovD. V.ЛитвиновД.В.
Russian Federation
ZerkalenkovaE. A.ЗеркаленковаЕ.А.
Russian Federation
SoldatkinaO. I.СолдаткинаО.И.
Russian Federation
LagoikoS. N.ЛагойкоС.Н.
Russian Federation
https://orcid.org/0000-0002-4779-1896MyakovaN. V.МяковаН.В.
Russian Federation
HenzeG.ХенцеГ. .
Germany
https://orcid.org/0000-0002-1643-5960RumiantsevA. G.РумянцевА.Г.
Russian Federation
KarachunskiiA. I.КарачунскийА.И.
Russian Federation
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, ImmunologyФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииPädiatrische Onkologie und Hämatologie Charité CVK, Universitätsmedizin BerlinPädiatrische Onkologie und Hämatologie Charité CVK09022018171374509082018Copyright ©; 2018, «D. Rogachev NMRCPHOI»Copyright ©; 2018, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2018«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/25

Childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with intrachromosomal amplification of chromosome 21 (iAMP21) has very unfavorable prognosis when treated according as standard risk group, mainly due to high risk of relapce. The outcome is improoving dramatically when the patients were treated as high risk. In our study we analyzed clinical parameters and outcome in children with BCP-ALL and iAMP21 according to trial Moscow-Berlin 2008 (ALL-MB 2008). The majority of patients were stratified in standard and intermediate risk group. Seven years event free survival (EFS) in patients with iAMP21 and without iAMP21 was 0.48 ± 0.24 and 0,87 ± 0,2 respectively with cumulative incidence of relapse 0.41 ± 0.24 и 0.07 ± 0.2. BCP-ALL with iAMP21 needs some changes in current stratification strategy and new approaches to treatment. For faster and accurate detection of iAMP21 evaluation by FISH technique must be applied.

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