Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children25210.24287/1726-1708-2019-18-2-114-119LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫSteroid cataract in patients with hemoblastosisСтероидная лекарственная катаракта у пациентов с гемобластозамиhttps://orcid.org/0000-0002-3585-7595SmirnovaA. B.СмирноваА. Б.
Russian Federation

Anna B. Smirnova, MD, ophthalmologist.

117997, Moscow, Samory Mashela st., 1.

Смирнова Анна Борисовна, врач-офтальмолог.

117997, Москва, ГСП-7, ул. Саморы Машела, 1.

anja03@yandex.ruhttps://orcid.org/0000-0002-6481-8608PershinB. S.ПершинБ. С.
Russian Federation
https://orcid.org/0000-0002-4779-1896MyakovaN. V.МяковаН. В.
Russian Federation
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России290620191821141192906201929062019Copyright ©; 2019, «D. Rogachev NMRCPHOI»Copyright ©; 2019, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2019«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/252

Modern technologies of treatment of children with oncohaematological diseases allowed to noticebly increase the survival indexes in this group of patients, enhancing the value of maintenance of their life quality. More than half of those who received long-term steriod and radiation treatment develop cataract that causes decrease in vision. In this review we represent data concerning mechanisms of cataract formation in patients after steriod and radiation treatment, results of anatomical, physiological and biochemical studies of the lens as well as metabolic changes in aqueous humor leading to cataract formation.

Современные технологии лечения детей с онкогематологическими заболеваниями позволили значительно повысить показатель выживаемости пациентов этой группы, актуализировав важность сохранения их качества жизни. Больше половины пациентов, получивших длительную стероидную и лучевую терапию, страдает катарактой, которая снижает остроту зрения. В обзоре приведен анализ литературы, описывающей закономерности развития катаракты у пациентов, получающих стероидную и лучевую терапию, результаты анатомо-физиологических и биохимических исследований хрусталика и изучения метаболических изменений внутриглазной жидкости, приводящих к развитию катаракты.

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