Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children29410.24287/1726-1708-2019-18-4-118-126LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫCytoreductive surgery and hyperthermic intraperitoneal chemotherapy in childrenЦиторедуктивные операции и внутрибрюшная гипертермическая химиоперфузия у детейAkhaladzeD. G.АхаладзеД. Г.
Russian Federation

Correspondence: Dmitry G. Akhaladze, МD, head of thoracoabdominal surgery group of Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare ofRussian Federation.

Address: Russia 117997, Moscow, Samory Mashela st., 1

Контактная информация: Ахаладзе Дмитрий Гурамович, канд. мед. наук, руководитель группы торакоабдоминальной хирургии НМИЦ детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава России.

Адрес: 117997, Москва, ГСП-7, ул. Саморы Машела, 1d.g.akhaladze@gmail.comRabaevG. S.РабаевГ. С.
Russian Federation

Moscow

Москва

GrachevN. S.ГрачёвН. С.
Russian Federation

Moscow

Москва

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России311220191841181263112201931122019Copyright ©; 2019, «D. Rogachev NMRCPHOI»Copyright ©; 2019, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2019«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/294

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC) is treatment of choice for determined group of adult patients. Cytoreduction and HIPEC is usually used in patients with ovarian, gastric and colorectal cancer, appednix cancer, peritoneal mesothelioma and in some tumors of another localization. The experience of cytoreductive surgery and HIPEC  in childhood is limited due to the lower frequency of peritoneal carcinomatosis in pediatric population. However, about 30% of malignant tumors in children develop in peritoneal cavity and pelvis. High recurrence rate are typical for these tumors, particularly due to tumor rupture. Taking into consideration low frequency of epithelioid tumors in children HIPEC is used for patients with other tumor types such as desmoplastic small round cell tumor (DSRCT), germ cell tumors, rhabdomyosarcoma and others. The aim o this paper is the review of the literature and present experience analysis of cytoreductive surgery and HIPEC in children.

Циторедуктивное оперативное вмешательство с проведением внутрибрюшной гипертермической химиотерапии (hyperthermic intraperitoneal chemotherapy – HIPEC) является операцией выбора у определенных групп пациентов взрослого возраста. Циторедукцию и HIPEC выполняют взрослым пациентам с раком яичников, желудка, колоректальным раком, при карциноме червеобразного отростка, мезотелиоме брюшины и ряде опухолей других локализаций. В педиатрической популяции опыт применения циторедукции и HIPEC ограничен, так как у детей реже встречается распространение злокачественных опухолей по брюшине. В то же время до 30% всех злокачественных новообразований у детей развиваются в брюшной полости и полости малого таза; для них характерна высокая частота рецидивов, особенно при повреждении целостности опухоли. Учитывая невысокую встречаемость эпителиальных  карцином у детей, HIPEC находит большее применение у пациентов с другими типами злокачественных опухолей, таких как десмопластическая мелкокруглоклеточная опухоль, герминогенно-клеточные опухоли, рабдомиосаркомы и др. В данной работе представлен анализ мирового опыта применения циторедукции и HIPEC в педиатрической практике.

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