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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">310</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2020-19-1-85-91</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Gemase for treatment of intraretinal hemorrhages and hemophthalmia at thrombocytopenia due to acute myeloid leukemia in children</article-title><trans-title-group xml:lang="ru"><trans-title>Гемаза в терапии интраретинальных кровоизлияний и гемофтальма при тромбоцитопении вследствие острого миелоидного лейкоза у детей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5606-4335</contrib-id><name-alternatives><name xml:lang="en"><surname>Koposova</surname><given-names>A. O.</given-names></name><name xml:lang="ru"><surname>Копосова</surname><given-names>А. О.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>the resident of Hematology (2nd year), </p><p>117997, Moscow, Samory Mashela st., 1</p></bio><bio xml:lang="ru"><p>ординатор второго года обучения по специальности «гематология»,</p><p>117997, Москва, ГСП-7. ул. Саморы Машела, 1</p></bio><email>anastasiiakoposova@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5145-7874</contrib-id><name-alternatives><name xml:lang="en"><surname>Petukhova</surname><given-names>А. В.</given-names></name><name xml:lang="ru"><surname>Петухова</surname><given-names>А. Б.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Moscow</p></bio><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0813-5626</contrib-id><name-alternatives><name xml:lang="en"><surname>Kalinina</surname><given-names>I. I.</given-names></name><name xml:lang="ru"><surname>Калинина</surname><given-names>И. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Moscow</p></bio><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6603-5749</contrib-id><name-alternatives><name xml:lang="en"><surname>Antonova</surname><given-names>K. S.</given-names></name><name xml:lang="ru"><surname>Антонова</surname><given-names>К. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Moscow</p></bio><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-03-28" publication-format="electronic"><day>28</day><month>03</month><year>2020</year></pub-date><volume>19</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>85</fpage><lpage>91</lpage><history><date date-type="received" iso-8601-date="2020-03-28"><day>28</day><month>03</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2020-03-28"><day>28</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/310">https://hemoncim.com/jour/article/view/310</self-uri><abstract xml:lang="en"><p>Intraretinal hemorrhages are the most common eye lesion in patients with hemoblastosis. Such patients have lower hemoglobin and platelet counts than those who haven’t hemorrhages. Hemophthalmia is the penetration of blood into the vitreous body or into one of the spaces formed around it. The reason for this may be vessels damage of the retina or newly formed vessels of the retina, that are more fragile compared to normal. Thrombocytopenia is one of the most common hematological symptoms in different blood diseases. Thrombocytopenia is a significant decrease in the number of circulating platelets (less than 100 × 109 /l), which leads to bleeding. Ophthalmic problems can occur in acute leukemia with thrombocytopenia, which can affect any anatomical structures of the eye. The relationship between hematological parameters and the nature of changes in the fundus has been established. The article provides analysis of two clinical cases of hemophthalmia in pediatric patients with acute myeloid leukemia and description of positive dynamics on therapy with Gemase. Parents gave their consent to use information about the child, including fotos, in the article.</p></abstract><trans-abstract xml:lang="ru"><p>Интраретинальные кровоизлияния – наиболее распространенное поражение зрительного анализатора у пациентов с гемобластозами. Такие пациенты имеют более низкие показатели гемоглобина и тромбоцитов по сравнению с теми, у кого геморрагий не выявлено. Гемофтальм – это проникновение крови в стекловидное тело или в одно из сформированных вокруг него пространств. Причиной этого может быть повреждение сосудов сетчатки при ее разрыве или новообразованных сосудов сетчатки, более хрупких по сравнению с нормальными. Тромбоцитопения – значительное снижение числа циркулирующих тромбоцитов (&lt; 100 × 109/л), которое приводит к кровотечениям. При острых лейкозах на фоне тромбоцитопении могут возникнуть офтальмологические проблемы, которые в свою очередь могут затронуть любые анатомические структуры глаза. Установлена зависимость между гематологическими показателями и характером изменений на глазном дне. В статье представлен разбор двух клинических случаев гемофтальма у пациентов с острым миелоидным лейкозом и описание динамики лечения на фоне терапии препаратом Гемаза. Родители дали согласие на использование информации, в том числе фото детей, в научных исследованиях и публикациях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>hemophthalmia</kwd><kwd>leukemia</kwd><kwd>intraretinal hemorrhages</kwd><kwd>intravitreal hemorrhages</kwd><kwd>thrombocytopenia</kwd><kwd>acute myeloid leukemia</kwd><kwd>children</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гемофтальм</kwd><kwd>лейкоз</kwd><kwd>интраретинальные кровоизлияния</kwd><kwd>интравитреальные кровоизлияния</kwd><kwd>тромбоцитопения</kwd><kwd>острый миелоидный лейкоз</kwd><kwd>дети</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Koshy J., John M.J., Thomas S., Kaur G., Batra N., Xavier W.J. Ophthalmic manifestations of acute and chronic leukemias presenting to a tertiary care center in India. Indian J Ophthalmol 2015; 63 (8): 659–64. 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