Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children31710.24287/1726-1708-2020-19-1-139-157LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫBlood coagulation in the 21st century: existing knowledge, current strategies for treatment and perspectiveСвертывание крови в XXI веке: новые знания, методы и перспективы для терапииhttps://orcid.org/0000-0001-8013-1112PodoplelovaN. A.ПодоплеловаН. А.
Russian Federation

Moscow

https://orcid.org/0000-0002-7102-6107SulimovV. B.СулимовВ. Б.
Russian Federation

Moscow

https://orcid.org/0000-0001-8701-5472IlinI. S.ТащиловаА. С.
Russian Federation

Moscow

https://orcid.org/0000-0002-3612-393XTashilovaA. S.ИльинИ. С.
Russian Federation

Moscow

https://orcid.org/0000-0002-8128-7757PanteleevM. A.ПантелеевМ. А.
Russian Federation

PhD, DSc, Head of the Laboratory of cellular hemostasis and trombosis,

117997, Moscow, Samory Mashela st., 1

д-р физ.-мат. наук, профессор, зав. лабораторией клеточного гемостаза и тромбоза,

117997, Москва, ГСП-7, ул. Саморы Машела, 1 

mapanteleev@yandex.ruhttps://orcid.org/0000-0002-4277-5838LedenevaI. V.ЛедeневаИ. В.
Russian Federation

Voronezh

https://orcid.org/0000-0002-6576-0305ShikhalievKh. S.ШихалиевХ. С.
Russian Federation

Voronezh

Russian Children's Clinical Hospital of the Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииCenter for Theoretical Problems of Physicochemical PharmakologyФГБУН «Центр теоретических проблем физико-химической фармакологии» РАНResearch Computing Center, Moscow State UniversityНаучно-исследовательский вычислительный центр ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»LLC DimontaООО «Димонта»Lomonosov Moscow State UniversityФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»Moscow Institute of Physics and Technology (State University)ФГБОУ ВО «Московский физико-технический институт (государственный университет)»Voronezh State UniversityФГБОУ ВО «Воронежский государственный университет»280320201911391572803202028032020Copyright ©; 2020, «D. Rogachev NMRCPHOI»Copyright ©; 2020, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2020«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/317

Disorders in the blood coagulation system are the leading cause of death and disability in the modern world. So the search for new drugs that can prevent pathological thrombosis, while not affecting normal hemostasis, becomes more relevant than ever. Recent studies has been a revolution in the understanding of the principles of work and the regulation of blood coagulation. In addition, new, more effective approaches to drug development have now appeared. For example computer simulation methods that can significantly reduce the time and resources spent on the search for new candidate molecules. In the review, the blood clotting system, the molekular mechanisms of thrombosis, the role of blood coagulation factors Xa and XIa, and the urgency of developing new inhibitors of these targets are shown, and the most interesting inhibitors of factors Xa and XIa are presented.

Нарушения в системе свертывания крови – лидирующая причина смертности и инвалидности в современном мире. В связи с этим как никогда актуальным становится поиск новых препаратов, способных предотвращать патологическое тромбообразование, не влияя при этом на нормальный гемостаз. Исследования последних десятилетий произвели переворот в понимании принципов работы и регуляции свертывания крови. Кроме того, появились новые, более эффективные подходы к разработке лекарств, в том числе методы компьютерного моделирования, позволяющие значительно сократить затраты времени и ресурсов на поиск новых молекул-кандидатов. В данном обзоре рассмотрены система свертывания крови, природа тромбоза, показана важная роль факторов Xa и XIa и причины, по которым их все чаще выбирают в качестве мишеней для разработки новых антикоагулянтов, а также представлены наиболее интересные из уже существующих ингибиторов, факторов свертывания Xa и XIa.

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