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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">352</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2020-19-2-170-176</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">The treatment of multiple organ dysfunction syndrome caused by gram-negative sepsis in a patient with neutropenia after allogeneic hematopoietic stem cell transplantation: a case report</article-title><trans-title-group xml:lang="ru"><trans-title>Лечение синдрома полиорганной недостаточности, вызванного грамотрицательным сепсисом, у пациента с нейтропенией после аллогенной трансплантации гемопоэтических стволовых клеток. Клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4348-4573</contrib-id><name-alternatives><name xml:lang="en"><surname>Ivanashkin</surname><given-names>A. Yu.</given-names></name><name xml:lang="ru"><surname>Иванашкин</surname><given-names>А. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Anesthesiologist-Intensivist at the Intensive Care Unit,</p><p>Russia, 117997, Moscow, Samory Mashela st., 1</p></bio><bio xml:lang="ru"><p>врач-анестезиолог-реаниматолог отделения реанимации и интенсивной терапии,</p><p>117997, Москва, ГСП-7, ул. Саморы Машела, 1</p></bio><email>ivanashkin@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8417-3555</contrib-id><name-alternatives><name xml:lang="en"><surname>Lazarev</surname><given-names>V. V.</given-names></name><name xml:lang="ru"><surname>Лазарев</surname><given-names>В. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8264-2258</contrib-id><name-alternatives><name xml:lang="en"><surname>Khamin</surname><given-names>I. G.</given-names></name><name xml:lang="ru"><surname>Хамин</surname><given-names>И. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4695-9765</contrib-id><name-alternatives><name xml:lang="en"><surname>Semenov</surname><given-names>I. A.</given-names></name><name xml:lang="ru"><surname>Семенов</surname><given-names>И. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0520-5630</contrib-id><name-alternatives><name xml:lang="en"><surname>Shelikhova</surname><given-names>L. N.</given-names></name><name xml:lang="ru"><surname>Шелихова</surname><given-names>Л. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0016-6698</contrib-id><name-alternatives><name xml:lang="en"><surname>Maschan</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Масчан</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology of Ministry of Healthcare of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-07-02" publication-format="electronic"><day>02</day><month>07</month><year>2020</year></pub-date><volume>19</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>170</fpage><lpage>176</lpage><history><date date-type="received" iso-8601-date="2020-07-02"><day>02</day><month>07</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2020-07-02"><day>02</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/352">https://hemoncim.com/jour/article/view/352</self-uri><abstract xml:lang="en"><p>Patients with high-dose chemotherapy-induced immunosuppression are at high risk for infectious complications with multiple organ dysfunction, which may lead to significantly higher mortality. We report a clinical case of multiple organ dysfunction syndrome caused by gram-negative septic shock in a child after allogeneic hematopoietic stem cell transplantation. We describe intensive care treatment modalities employed at different stages of therapy as well as the specifics of vital signs monitoring. The patient's parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.</p></abstract><trans-abstract xml:lang="ru"><p>Пациенты с иммуносупрессией, индуцированной высокодозной химиотерапией, подвержены высокому риску инфекционных осложнений с развитием полиорганной недостаточности, что может существенно увеличить летальность. Приводится клинический случай синдрома полиорганной недостаточности, обусловленного септическим шоком грамотрицательной этиологии, у ребенка после выполненной аллогенной трансплантации гемопоэтических стволовых клеток. Описаны методы интенсивной терапии на отдельных этапах лечения, особенности мониторинга показателей жизнедеятельности. Родители дали согласие на использование информации, в том числе фотографий ребенка, в научных исследованиях и публикациях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>gram-negative sepsis</kwd><kwd>septic shock</kwd><kwd>neutropenia</kwd><kwd>hematopoietic stem cell transplantation</kwd><kwd>multiple organ dysfunction syndrome</kwd><kwd>acute respiratory distress syndrome</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>грамотрицательный сепсис</kwd><kwd>септический шок</kwd><kwd>нейтропения</kwd><kwd>трансплантация гемопоэтических стволовых клеток</kwd><kwd>синдром полиорганной недостаточности</kwd><kwd>острый респираторный дистресс-синдром</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Balit C.R., Horan R., Dorofaeff T., Frndova H., Doyle J., Cox P.N., et al. Pediatric Hematopoietic Stem Cell Transplant and Intensive Care: Have Things Changed? 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