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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">381</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2020-19-3-42-49</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Organizational aspects of acute massive blood loss therapy in pediatric surgical oncology</article-title><trans-title-group xml:lang="ru"><trans-title>Организационные аспекты терапии острой массивной кровопотери при хирургической коррекции онкологических заболеваний у детей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4364-8937</contrib-id><name-alternatives><name xml:lang="en"><surname>Leonov</surname><given-names>N. P.</given-names></name><name xml:lang="ru"><surname>Леонов</surname><given-names>Н. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Anesthesiologist and Intensive care doctor, Department of Anesthesiology and Resuscitation with Surgical Unit,</p><p>117997, Moscow, Samory Mashela st., 1</p></bio><bio xml:lang="ru"><p>канд. мед. наук, врач-анестезиологреаниматолог отделения анестезиологии и реанимации с операционным блоком,</p><p>117997, Москва, ул. Саморы Машела, 1 </p></bio><email>NikoLeonov@ya.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7945-2565</contrib-id><name-alternatives><name xml:lang="en"><surname>Shchukin</surname><given-names>V. V.</given-names></name><name xml:lang="ru"><surname>Щукин</surname><given-names>В. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>117997, Moscow, Samory Mashela st., 1</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2322-5734</contrib-id><name-alternatives><name xml:lang="en"><surname>Novichkova</surname><given-names>G. A.</given-names></name><name xml:lang="ru"><surname>Новичкова</surname><given-names>Г. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>117997, Moscow, Samory Mashela st., 1</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5230-5725</contrib-id><name-alternatives><name xml:lang="en"><surname>Spiridonova</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Спиридонова</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>117997, Moscow, Samory Mashela st., 1</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Ministry of Healthcare of Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Московский государственный медико-стоматологический университет им. А.И. Евдокимова» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2020-09-08" publication-format="electronic"><day>08</day><month>09</month><year>2020</year></pub-date><volume>19</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>42</fpage><lpage>49</lpage><history><date date-type="received" iso-8601-date="2020-10-03"><day>03</day><month>10</month><year>2020</year></date><date date-type="accepted" iso-8601-date="2020-10-03"><day>03</day><month>10</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/381">https://hemoncim.com/jour/article/view/381</self-uri><abstract xml:lang="en"><p>The organization of acute massive blood loss therapy in pediatric surgical requires an interdisciplinary approach in each medical center, depending on their profile. In our center, a protocol of acute massive blood loss therapy in pediatric surgical oncology has been developed and implemented. Systematic training of personnel and the development of team skills in the simulation class of the center became the basis for its implementation. In addition, the earlier initiation of therapy (with blood loss of more than 1 ml/kg/min) and actions aimed at reducing the time of critical hypotension became important conditions of the protocol. The acquired coagulopathy therapy and the prevention of massive transfusion syndrome are carried out only after the normalization of systemic hemodynamics. We present our experience of using this protocol in a 3-year-old child with acute massive blood loss more than 400% of the circulating blood volume during surgical removal of сhoriocarcinoma. The presented clinical case demonstrates not only the dramatic nature of the course of the disease, but also the good results of the organization and coordination of the joint work of all the center’s specialists. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. Parents gave their consent to use information about the child, including fotos, in the article.</p></abstract><trans-abstract xml:lang="ru"><p>Организация терапии острой массивной кровопотери (ОМК) у детей во время хирургических операций требует междисциплинарного подхода в каждом лечебном учреждении в зависимости от его профиля. В НМИЦ ДГОИ им. Дмитрия Рогачева разработан и внедрен протокол терапии ОМК, применяемый у детей во время хирургической коррекции онкологических заболеваний. Систематическое обучение персонала и развитие командных навыков в симуляционном классе Центра стало основой его реализации. Кроме этого, важными компонентами протокола являются раннее начало терапии (инициация при кровопотере более 1 мл/кг/мин) и действия, направленные на снижение времени критической гипотензии. Терапия приобретенной коагулопатии и профилактика синдрома массивных трансфузий проводятся только после нормализации системной гемодинамики. Мы представляем свой опыт применения данного протокола у ребенка 3 лет с ОМК более 400% объема циркулирующей крови при хирургическом удалении хориоидкарциномы. Представленный клинический случай демонстрирует не только драматизм течения заболевания, но и хорошие результаты слаженной, прекрасно организованной и координированной совместной работы всех специалистов Центра. Данное исследование одобрено независимым этическим комитетом и утверждено решением ученого совета ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России. Родители дали согласие на использование информации (результатов обследования, лечения и наблюдения), в том числе фотографий ребенка, в научных исследованиях и публикациях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>acute massive blood loss</kwd><kwd>protocol</kwd><kwd>children</kwd><kwd>cancer</kwd><kwd>clinical case</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>острая массивная кровопотеря</kwd><kwd>протокол</kwd><kwd>дети</kwd><kwd>онкологические заболевания</kwd><kwd>клинический случай</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Авторы статьи выражают благодарность всем специалистам ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России, принявшим участие в реализации данного протокола ОМК.</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Феоктистов П.И., Карманов И.Е. 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