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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">39</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2018-17-1-136-143</article-id><article-categories><subj-group subj-group-type="toc-heading"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Hodgkin's lymphoma relapses and refractory forms therapy variants in children, adolescents and young adults</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности терапии рецидивов и рефрактерных форм лимфомы Ходжкина у детей, подростков и молодых взрослых</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2057-2036</contrib-id><name-alternatives><name xml:lang="en"><surname>Pshonkin</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Пшонкин</surname><given-names>А.В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, pediatric hematologist/oncologist, head of Outpatient Department</p><p>Russia 117997, Moscow, Samory Mashela st., 1 +7 (495) 287-6570</p></bio><email>alexey.pshonkin@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Evstratov</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Евстратов</surname><given-names>Д.А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4779-1896</contrib-id><name-alternatives><name xml:lang="en"><surname>Myakova</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Мякова</surname><given-names>Н.В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2018-02-09" publication-format="electronic"><day>09</day><month>02</month><year>2018</year></pub-date><volume>17</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>136</fpage><lpage>143</lpage><history><date date-type="received" iso-8601-date="2018-08-09"><day>09</day><month>08</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2018, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2018, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/39">https://hemoncim.com/jour/article/view/39</self-uri><abstract xml:lang="en"><p>Hodgkin lymphoma has been studied more than any other type of lymphoma. The result of those studies has lead to rapid advances in the diagnosis and treatment of the disease. The vast majority of Hodgkin lymphoma patients can be cured after first line treatment. And even for those patients who relapse or become refractory, secondary therapies are often successful in providing another remission and cure the patient. The prescribed type of treatment for individual patients depends on several factors, such as time of relapse occurance, the patient’s age, overall health and previous therapies received.</p></abstract><trans-abstract xml:lang="ru"><p>Лимфома Ходжкина (ЛХ) - прогностически один из наиболее благоприятных вариантов злокачественных лимфопролиферативных заболеваний. В настоящее время у большинства пациентов с ЛХ удается достичь ремиссии после первой линии терапии. И даже для тех пациентов, у которых происходит рецидив или имеет место первично-рефрактерное течение ЛХ, доступны высокоэффективные опции специфической терапии второй, третьей линий лечения. Выбор варианта лечения зависит от нескольких факторов, в том числе от времени возникновения рецидива, возраста пациента, общего его состояния и предыдущих методов лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Hodgkin's lymphoma</kwd><kwd>children</kwd><kwd>adolescents</kwd><kwd>relapse</kwd><kwd>primary refractory</kwd><kwd>methods of treatment</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>лимфома Ходжкина</kwd><kwd>дети</kwd><kwd>подростки</kwd><kwd>рецидив</kwd><kwd>первично-рефрактерное течение</kwd><kwd>методы лечения</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>European age-standardised rates calculated by the Statistical Information Team at Cancer Research UK, 2011 using data from GLOBOCAN, IARC, version 1.2.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Ries L.A.G., Harkins D., Krapcho M., Mariotto A., Miller B.A., Feuer E.J., et al. 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