Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children39010.24287/1726-1708-2020-19-3-105-113CLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯTherapy-related acute myeloid leukemia in a patient with neuroblastoma: case reportСлучай развития вторичного миелоидного лейкоза у пациента с нейробластомойhttps://orcid.org/0000-0001-7479-0007UtalievaD. T.УталиеваД. Т.
Russian Federation

Physician of Department of Сlinical Оncology, 

117997, Moscow, Samory Mashela st., 1

врач отделения клинической онкологии,

117997, Москва, ул. Саморы Машела, 1 

clinoncology@gmail.comhttps://orcid.org/0000-0002-0813-5626KalininaI. I.КалининаИ. И.
Russian Federation

117997, Moscow, Samory Mashela st., 1

117997, Москва, ул. Саморы Машела, 1

https://orcid.org/0000-0002-3704-8783KachanovD. Yu.КачановД. Ю.
Russian Federation

117997, Moscow, Samory Mashela st., 1

117997, Москва, ул. Саморы Машела, 1

https://orcid.org/0000-0001-8610-0624EvseevD. A.ЕвсеевД. А.
Russian Federation

117997, Moscow, Samory Mashela st., 1

117997, Москва, ул. Саморы Машела, 1

https://orcid.org/0000-0001-8129-0545ShcherbakovA. P.ЩербаковА. П.
Russian Federation

117997, Moscow, Samory Mashela st., 1

117997, Москва, ул. Саморы Машела, 1

DubrowinaM. Ye.ДубровинаМ. Э.
Russian Federation

117997, Moscow, Samory Mashela st., 1

117997, Москва, ул. Саморы Машела, 1

https://orcid.org/0000-0002-9654-084XMoiseenkoR. A.МоисеенкоР. А.
Russian Federation

117997, Moscow, Samory Mashela st., 1

117997, Москва, ул. Саморы Машела, 1

https://orcid.org/0000-0002-6158-2222LikarYu. N.ЛикарьЮ. Н.
Russian Federation

117997, Moscow, Samory Mashela st., 1

117997, Москва, ул. Саморы Машела, 1

https://orcid.org/0000-0002-3767-4477ShamanskayaT. V.ШаманскаяТ. В.
Russian Federation

117997, Moscow, Samory Mashela st., 1

117997, Москва, ул. Саморы Машела, 1

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation,ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России080920201931051130510202005102020Copyright ©; 2025, «D. Rogachev NMRCPHOI»Copyright ©; 2025, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2025«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/390

Modern, risk-adapted treatment approaches for intermediate and high-risk neuroblastoma (NB) have led to an increasing numbers of survivors. However, intensive multimodal treatment strategy is associated with a significantly increased risk of secondary malignancies. It is currently known that alkylating agents, topoisomerase II inhibitors, and platinum compounds induce treatment-related leukemia. This article presents a literature review and description of a clinical case of secondary acute myeloid leukemia (s-AML) developed 57 months after the initial diagnosis in a patient with intermediate-risk NB who received intensive first-line and post-relapse chemotherapy. The debut of s-AML required a differential diagnosis to rule out a relapse of NB. Parents gave their consent to use information about the child, including fotos, in the article.

Современные успехи детской онкологии улучшили показатели выживаемости пациентов с нейробластомой (НБ) группы промежуточного и высокого риска. В то же время интенсивная мультимодальная терапия приводит к увеличению частоты встречаемости вторичных злокачественных новообразований у выживших пациентов. В настоящее время известно, что алкилирующие агенты, ингибиторы топоизомеразы II и препараты платины могут приводить к развитию вторичного острого миелоидного лейкоза (ОМЛ). В данной статье представлены литературный обзор и описание клинического случая развития вторичного ОМЛ через 57 мес от установления первичного диагноза у пациента с НБ группы промежуточного риска, получавшего интенсивную химиотерапию в 1-й линии и в рецидиве заболевания. Дебют вторичного ОМЛ потребовал выполнения ряда диагностических исследований для исключения рецидива НБ. Родители дали согласие на использование информации, в том числе фотографий ребенка, в научных исследованиях и публикациях.

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