Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children39610.24287/1726-1708-2020-19-3-144-150LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫCurrent trends in blood coagulation studiesСовременные направления в исследованиях свертывания кровиhttps://orcid.org/0000-0003-1494-3125ShibekoA. M.ШибекоА. М.
Russian Federation

PhD, leading researcher, laboratory of biophysics, 

117997, Moscow, Samory Mashela st., 1

канд. биол. наук, ведущий научный сотрудник лаборатории биофизики,

117997, Москва, ул. Саморы Машела, 1 

alshibeko@gmail.comBalandinaA. N.БаландинаА. Н.
Russian Federation

117997, Moscow, Samory Mashela st., 1

117997, Москва, ул. Саморы Машела, 1

https://orcid.org/0000-0001-8013-1112PodoplelovaN. A.ПодоплеловаН. А.
Russian Federation

117997, Moscow, Samory Mashela st., 1

117997, Москва, ул. Саморы Машела, 1

https://orcid.org/0000-0002-8128-7757PanteleevM. A.ПантелеевМ. А.
Russian Federation

117997, Moscow, Samory Mashela st., 1

117997, Москва, ул. Саморы Машела, 1

Center for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of SciencesФГБУН «Центр теоретических проблем физико-химической фармакологии» РАНDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России080920201931441500810202008102020Copyright ©; 2025, «D. Rogachev NMRCPHOI»Copyright ©; 2025, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2025«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/396

Blood coagulation occurs in flow or stasis conditions, it involves components of cell hemostasis and enzymatic cascades of reactions; it serves to stop bleeding yet it can lead to life-threatening blood thrombi. Despite the fact that a complete list of coagulation proteins was well known for decades, in recent years numerous facts has accumulated about its structure and regulation. All that has led to the creation of new methods for diagnosing of blood coagulation disorders and methods for their correction. Congenital and acquired coagulation disorders are still an acute clinical problem. This review shows modern ideas about the structure and functioning of the blood coagulation system in various conditions.

Свертывание крови происходит в условиях ее тока и стазиса, оно задействует компоненты клеточного гемостаза и ферментативные каскады реакций, служит для остановки кровотечений и может приводить к возникновению угрожающих жизни тромбов. Несмотря на то, что полный список белков свертывания сформировался несколько десятилетий назад, за последние годы накопилась многочисленная новая информация о его устройстве и регуляции, что привело к созданию новых методов диагностики его нарушений и способов их коррекции. Врожденные и приобретенные нарушения свертывания крови до сих пор остаются острой клинической проблемой. В данном обзоре показаны современные представления об устройстве и функционировании системы свертывания крови в различных условиях.

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