Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children43010.24287/1726-1708-2020-19-4-143-149CLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯА сlinical case report of mediastinal teratoma in an adolescent patient with Klinefelter syndromeКлинический случай медиастинальной тератомы у подростка с синдромом Клайнфельтераhttps://orcid.org/0000-0003-0262-8515SaliyevaS. S.СалиеваС. С.
Kazakhstan

Symbat S. Saliyeva, a physician at the Oncology Department №2

46 Al-Farabi Avenue, Almaty A15E2P4

Салиева Сымбат Сарыбаевна, врач отделения онкологии №2 

A15E2P4, Алматы, просп. Аль-Фараби, 146

symbatsaliyeva@gmail.comhttps://orcid.org/0000-0002-7154-6436BoranbayevaR. Z.БоранбаеваР. З.
Kazakhstan

Almaty

Алматы

https://orcid.org/0000-0002-0882-7323ZhumadullayevB. M.ЖумадуллаевБ. М.
Kazakhstan

Almaty

Алматы

https://orcid.org/0000-0002-5735-4032KhairovK. E.ХаировК. Э.
Kazakhstan

Almaty

Алматы

https://orcid.org/0000-0002-1263-249XKrivenkoE. V.КривенкоЕ. В.
Kazakhstan

Almaty

Алматы

https://orcid.org/0000-0003-2725-9920TainekovaA. Sh.ТайнековаА. Ш.
Kazakhstan

Almaty

Алматы

https://orcid.org/0000-0002-3595-5574BekishevaA. N.БекишеваА. Н.
Kazakhstan

Almaty

Алматы

https://orcid.org/0000-0001-6889-0749KarazhanovaM. K.КаражановаМ. К.
Kazakhstan

Almaty

Алматы

Scientific Center of Pediatrics and Pediatric SurgeryАО «Научный центр педиатрии и детской хирургии»081220201941431492112202021122020Copyright ©; 2025, «D. Rogachev NMRCPHOI»Copyright ©; 2025, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2025«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/430

Teratoma is a germ cell tumor, which consists of derivatives of three germ layers and has various malignant potentials – from benign mature forms to immature embryonic forms with a somatic type of malignancy. Even the mature type of teratoma is biologically unpredictable providing for an ability to grow locally with invasion. Necessity for complete removal of tumors, wherever they are located, is explained by the fact that there is a risk of a possible development of growing teratoma syndrome or transformation into malignant tumors. This article describes the clinical case of growing teratoma syndrome of mediastinal localization in a teenager with Klinefelter syndrome, also as an example of the multidisciplinary approach of pediatric oncologists, surgeons, radiotherapists and pathomorphologists in decision-making for optimal treatment. The patients' parents gave their consent to the use of their child's data, including photographs, for research purposes and in publications.

Тератома – герминогенноклеточная опухоль, которая состоит из производных 3 зародышевых листков и имеет различный злокачественный потенциал – от доброкачественных зрелых форм до незрелых эмбриональных форм с соматическим типом малигнизации. Даже зрелый вариант тератомы биологически непредсказуем с учетом ее способности к локальному росту с инвазией. Необходимость полного удаления опухоли вне зависимости от места расположения объясняется тем, что есть риск возможного развития синдрома растущей тератомы или трансформации ее в злокачественные формы. В данной статье приведено описание клинического случая синдрома растущей тератомы медиастинальной локализации у подростка с синдромом Клайнфельтера, а также представлен пример мультидисциплинарного подхода детских онкологов, хирургов, лучевых диагностов и патоморфологов в выборе оптимального лечения. Родители дали согласие на использование информации, в том числе фотографий ребенка, в научных исследованиях и публикациях.

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