Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children43510.24287/1726-1708-2020-19-4-185-197LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫJuvenile nasopharyngeal angiofibromaЮвенильная ангиофиброма носоглотки и основания черепаhttps://orcid.org/0000-0003-1099-9332KrasnovA. S.КрасновА. С.
Russian Federation

Alexey S. Krasnov, а researcher at the Department of Diagnostic Radiology

1 Samory Mashela St., Moscow 117997

Краснов Алексей Сергеевич, научный сотрудник отдела лучевой диагностики 

117997, Москва, ул. Саморы Машела, 1 

alexey.s.krasnov@gmail.comhttps://orcid.org/0000-0002-4451-3233GrachevN. S.ГрачёвН. С.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0003-3986-3770VorozhtsovI. N.ВорожцовИ. Н.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0001-7317-7104TereschenkoG. V.ТерещенкоГ. В.
Russian Federation

Moscow

Москва

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology Ministry of Healthcare of Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России081220201941851972212202022122020Copyright ©; 2025, «D. Rogachev NMRCPHOI»Copyright ©; 2025, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2025«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/435

Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign tumor that affects almost exclusively male adolescents. Usually, symptoms of JNA are detected within 15–24 months before seeking medical help. JNA is mainly diagnosed in patients aged 14 to 25 years. Angiofibroma consists of a complex mixture of blood vessels and a fibrous stroma. This feature of their structure determines the property of the tumor to bleed massively even after minimal surgical procedures. The tumor usually grows posteriorly and upward, involving the sphenoid sinus. Under certain circumstances, it can spread anteriorly into the nasal cavity with the involvement of ethmoid cells. With lateral spread, it affects the space of the pterygo-palatine fossa and can also spread into the infratemporal fossa through the expanded pterygo-maxillary fissure, into the region of the chewing muscles and soft tissues of the cheek. In this review, we briefly outline the study history, and current aspects of etiology, pathogenesis, diagnostic and treatment methods of JNA.

Ювенильная ангиофиброма носоглотки и основания черепа (ЮАН) является редкой доброкачественной опухолью, поражающей почти исключительно подростков мужского пола. Обычно симптомы ЮАН выявляются в течение 15–24 мес до обращения за медицинской помощью. ЮАН в основном диагностируется у пациентов в возрасте от 14 до 25 лет. Ангиофиброма состоит из сложной смеси кровеносных сосудов и фиброзной стромы. Эта особенность определяет свойство опухоли массивно кровоточить даже после минимальных хирургических манипуляций. Опухоль обычно растет кзади и вверх, вовлекая клиновидную пазуху, может распространяться кпереди в полость носа с вовлечением клеток решетчатой кости. При латеральном распространении поражает пространство крыловидно-небной ямки, а также может распространяться в подвисочную ямку, в область жевательных мышц и мягких тканей щеки. В этом обзоре мы кратко изложим историю изучения, клиническую картину, этиологию, патогенез, лучевую диагностику заболевания, а также представим актуальные способы лечения и возможные осложнения при лечении ЮАН.

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