Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children43910.24287/1726-1708-2020-19-4-234-242LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫErythrocyte as an ideal carrier for intavascular drug deliveryЭритроцит как идеальный носитель для внутрисосудистой доставки лекарствhttps://orcid.org/0000-0001-8803-5694KolevaL. D.КолеваЛ. Д.
Russian Federation

Larisa D. Koleva, junior researcher of the Laboratory of Biophysics

1 Samory Mashela St., Moscow 117997

Колева Лариса Дмитриевна, младший научный сотрудник лаборатории биофизики

117997, Москва, ул. Саморы Машела, 1

larulea@mail.ruhttps://orcid.org/0000-0003-3403-181XAtaullakhanovF. I.АтауллахановФ. И.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0002-5948-3444SinauridzeE. I.СинауридзеЕ. И.
Russian Federation

Moscow

Москва

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииCenter for Theoretical Problems of Physical and Chemical Pharmacology, Russian Academy of SciencesФГБУН «Центр теоретических проблем физико-химической фармакологии» РАНLomonosov Moscow State UniversityФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»081220201942342422212202022122020Copyright ©; 2025, «D. Rogachev NMRCPHOI»Copyright ©; 2025, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2025«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/439

Drug delivery using natural biological carriers, especially erythrocytes, is a rapidly developing field. Erythrocytes can act as carriers with the gradual release of a pharmacological agent, as bioreactors with encapsulated enzymes, or as a tool for targeted delivery of drugs to target organs especially tissue macrophages, liver and spleen. To date, red blood cells have been studied as carriers for a wide range of drug compounds, such as enzymes, antibiotics, anti-inflammatory, antiviral drugs, etc. The review is devoted to the advantages of erythrocytes as carriers for the delivery of drugs loaded into the erythrocyte, or related to its surface, and defines the main directions of research on erythrocytes carriers of biologically active substances. Particular attention is paid to in vivo studies that reveal the potential of carrier erythrocytes for clinical use.

Доставка лекарств с использованием природных биологических носителей, в частности эритроцитов, является быстро развивающейся областью изучения. Эритроциты могут действовать как носители с постепенным высвобождением фармакологического агента, в качестве биореакторов с инкапсулированными ферментами или в качестве инструмента для направленной доставки лекарств в органы-мишени, прежде всего в тканевые макрофаги, печень и селезенку. На сегодняшний день эритроциты изучены в качестве носителей для широкого спектра лекарственных соединений, таких как ферменты, антибиотики, противовоспалительные, противовирусные препараты и т. д. Обзор посвящен преимуществам эритроцитов как носителей для доставки лекарств, загруженных в них, или связанных с их поверхностью, и определяет основные направления исследований эритроцитов-носителей биологически активных веществ. Особое внимание уделяется исследованиям in vivo, раскрывающим потенциал эритроцитов-носителей для клинического применения.

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