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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">472</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2021-20-4-139-144</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Extensive liver resection in a child with an extremely low future liver remnant volume</article-title><trans-title-group xml:lang="ru"><trans-title>Обширная резекция печени у ребенка при экстремально низком объеме будущего остатка</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1387-209X</contrib-id><name-alternatives><name xml:lang="en"><surname>Akhaladze</surname><given-names>D. G.</given-names></name><name xml:lang="ru"><surname>Ахаладзе</surname><given-names>Д. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>cand. med. sci., Head of Thoracoabdominal Surgery Group,</p><p>1 Samory Mashela St., Moscow 117997</p></bio><bio xml:lang="ru"><p>канд. мед. наук, руководитель отдела торакоабдоминальной хирургии,</p><p>117997, Москва, ул. Саморы Машела, 1</p></bio><email>d.g.akhaladze@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5691-2522</contrib-id><name-alternatives><name xml:lang="en"><surname>Rabaev</surname><given-names>G. S.</given-names></name><name xml:lang="ru"><surname>Рабаев</surname><given-names>Г. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow 117997</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><email>rabaevgesha@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0404-6420</contrib-id><name-alternatives><name xml:lang="en"><surname>Merkulov</surname><given-names>N. N.</given-names></name><name xml:lang="ru"><surname>Меркулов</surname><given-names>Н. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow 117997</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><email>dr.mernick@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5150-1436</contrib-id><name-alternatives><name xml:lang="en"><surname>Tverdov</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Твердов</surname><given-names>И. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow 117997</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><email>twerdov.iwan@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4451-3233</contrib-id><name-alternatives><name xml:lang="en"><surname>Grachev</surname><given-names>N. S.</given-names></name><name xml:lang="ru"><surname>Грачёв</surname><given-names>Н. С.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>1 Samory Mashela St., Moscow 117997</p></bio><bio xml:lang="ru"><p>117997, Москва, ул. Саморы Машела, 1</p></bio><email>nick-grachev@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-12-22" publication-format="electronic"><day>22</day><month>12</month><year>2021</year></pub-date><volume>20</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>139</fpage><lpage>144</lpage><history><date date-type="received" iso-8601-date="2021-03-29"><day>29</day><month>03</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-06-21"><day>21</day><month>06</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/472">https://hemoncim.com/jour/article/view/472</self-uri><abstract xml:lang="en"><p>The incidence of posthepatectomy liver failure in adult patients and a large number of complications of two-stage liver resections require a search for criteria that allow highly accurate assessment of the risk of liver failure. For this purpose, the study of the future liver remnant volume and function have been widely introduced among adult patients, and the future liver remnant function measurement reflects the greater sensitivity. The absence of references to posthepatectomy liver failure, as well as the experience of determining the functional reserve of the future liver remnant in children, let us to suggest the possibility of a wider using one-stage liver resections when the future liver remnant volume is below the generally accepted threshold (25% of the healthy liver parenchyma volume) in the case of the functional reserve sufficient value. This clinical case describes the successful extended right hemihepatectomy and segmentectomy 1 in a 3-year patient with a future liver remnant volume of 16.5% without clinical signs of postresection hepatic failure, which confirms the thesis of the need to assess the functional liver reserve in pediatric oncology to reduce the frequency of two-stage resections and liver transplants. The patient’s parents gave consent to the use of their child’s data, including photographs, for research purposes and in publications. </p></abstract><trans-abstract xml:lang="ru"><p>Частота пострезекционной печеночной недостаточности у взрослых пациентов, большое количество осложнений двухэтапных резекций печени требуют поиска критериев, позволяющих с высокой точностью оценить риск развития печеночной недостаточности. В этих целях во взрослой хирургической гепатологии широко внедрено исследование объема и функции будущего остатка печени, отражающее бóльшую чувствительность именно функционального показателя. Отсутствие упоминаний о пострезекционной печеночной недостаточности в литературе, а также опыт определения функционального резерва будущего остатка печени в детской практике позволяют предположить возможность более широкого применения одноэтапных резекций печени при показателях объема ее будущего остатка ниже общепринятого порогового (25% объема здоровой паренхимы печени) в случае достаточного значения функционального резерва. Приведенное клиническое наблюдение описывает успешное выполнение правосторонней расширенной гемигепатэктомии и сегментэктомии-1 у пациента 3 лет с объемом остатка 16,5% без клинических признаков пострезекционной печеночной недостаточности, что подтверждает тезис о необходимости оценки функционального резерва печени в детской онкологии для снижения частоты неоправданных двухэтапных резекций и трансплантаций печени. Родители пациента дали согласие на использование информации, в том числе фотографий ребенка, в научных исследованиях и публикациях. </p></trans-abstract><kwd-group xml:lang="en"><kwd>liver resections</kwd><kwd>two-stage liver resections</kwd><kwd>posthepatectomy liver failure</kwd><kwd>hepatobiliary scintigraphy</kwd><kwd>future liver remnant function</kwd><kwd>children</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>резекции печени</kwd><kwd>двухтапные резекции печени</kwd><kwd>пострезекционная печеночная недостаточность</kwd><kwd>гепатобилиарная сцинтиграфия</kwd><kwd>функция будущего остатка печени</kwd><kwd>дети</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Koerkamp B.G., Wiggers J.K., Gonen M., Doussot A., Allen P.J., Besselink M.G.H., et al. Survival after resection of perihilar cholangiocarcinoma-development and external validation of a prognostic nomogram. Ann Oncol 2015; 26 (9): 1930–5. 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