Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children52410.24287/1726-1708-2021-20-4-199-208LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫParenteral nutritional support in children in the early period after hematopoietic stem cell transplantation: specifics and clinical aspectsПарентеральная нутритивная поддержка у детей в раннем периоде после трансплантации гемопоэтических стволовых клеток: особенности и клинические аспектыhttps://orcid.org/0000-0002-4296-3345VashuraA. Yu.ВашураА. Ю.
Russian Federation

Head of Department of Scientific Basics of Nutrition and Nutrition and Metabolic Therapy, the Russkoe Pole Treatment andRehabilitation Center,

1 Samory Mashela St., Moscow 117997

заведующий отделом научных основ питания и нутритивно-метаболической терапии ЛРНЦ «Русское поле»,

117997, Москва, ул. Саморы Машела, 1

avashura@gmail.comAlymovaYu. A.АлымоваЮ. А.
Russian Federation

1 Samory Mashela St., Moscow 117997

117997, Москва, ул. Саморы Машела, 1

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian FederatioФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России221220212041992082106202119082021Copyright ©; 2021, «D. Rogachev NMRCPHOI»Copyright ©; 2021, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2021«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/524

Hematopoietic stem cell transplantation (HSCT) as a treatment modality is associated with nutritional problems that are mainly caused by eating difficulties and gastrointestinal complications occurring at different stages of HSCT: starting from conditioning until late post-transplant period. Nutritional problems have in turn a negative impact on the outcomes of HSCT which demonstrates the importance of preventive measures and timely correction of these problems. The majority of patients who underwent HSCT experience various problems at different stages of treatment leading to a situation when enteral nutrition is impossible. This is why parenteral nutrition is of utmost importance in these patients. This review describes the main clinical factors that may influence the prescription of nutritional support to patients after HSCT as well as possible problems and negative consequences of inappropriate prescribing of parenteral nutrition. 

Трансплантация гемопоэтических стволовых клеток (ТГСК) как метод лечения ассоциирована с нутритивными нарушениями, основные причины которых – нарушения приема пищи и гастроинтестинальные проблемы, развивающиеся на разных этапах: от кондиционирования до позднего посттрансплантационного периода. Нутритивные нарушения негативно влияют на результаты ТГСК, в связи с чем становится ясной актуальность их профилактики и своевременной коррекции. У большинства пациентов, перенесших ТГСК, на различных этапах терапии имеются те или иные проблемы, приводящие к невозможности обеспечения нутритивной потребности энтеральным путем. Поэтому парентеральный путь алиментации у таких пациентов является особенно важным. В обзоре рассмотрены основные клинические особенности назначения парентерального питания пациентам после ТГСК, а также возможные проблемы и негативные последствия его неадекватного назначения. 

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