Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children5410.24287/1726-1708-2017-16-2-45-49СтатьиPediatric clinical case of parameningeal undifferentiated pleomorphic sarcoma treated with chemoradiotherapyКлинический случай химиолучевой терапии недифференцированной плеоморфной саркомы параменингеальной локализации у ребенкаhttps://orcid.org/0000-0001-8313-9056UsychkinaA. Y.УсычкинаА. Ю.
Russian Federation

MD, pediatric oncologist Department of Radiation Therapy

Russia 117997, Moscow, Samory Mashela st., 1 Tel.: +7 (916)-695-0460

врач – детский онколог отделения лучевой терапии ННПЦ детской гематологии

117997, Москва, ГСП-7, ул. Саморы Машела, 1 Тел.: +7 (916)-695-0460

usychkina@gmail.comKobyzevaD. A.КобызеваД. А.
Russian Federation
GornostaevV. V.ГорностаевВ. В.
Russian Federation
LoginovaA. A.ЛогиноваА. А.
Russian Federation
https://orcid.org/0000-0002-3704-8783KachanovD. Y.КачановД. Ю.
Russian Federation
VarfolomeevaS. R.ВарфоломееваС. Р.
Russian Federation
RoshinV. Y.РощинВ. Ю.
Russian Federation
NechesnyukA. V.НечеснюкА. В.
Russian Federation
National Scientific and Practical Center of Pediatric Hematology, Oncology and Immunology named after Dmitry RogachevФГБУ «Национальный научно-практический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, Москва10062017162454910082018Copyright ©; 2017, «D. Rogachev NMRCPHOI»Copyright ©; 2017, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2017«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/54

Malignant fibrous histiocytoma (MFH) is a rare “NON-RMS-LIKE” pediatric tumor with highly malignant clinical behavior, high metastatic potential and overall 5-year survival around 65-70%. Soft tissue  sarcoma diagnostic work-up and optimal combination of systemic therapy and local therapy approaches are one of  the most challenging issues in modern pediatric oncology. To present a clinical case of parameningeal  undifferentiated pleomorphic sarcoma in 7-year old child treated with adaptive conformal radiotherapy  aimed at local tumor control. We describe a method of combined treatment of patient with parameningeal  UPS consisting of the intensity-modulated radiotherapy (IMRT) in the form of volumetrically-modulated arc- therapy (VMAT) aimed at local tumor control. The radiotherapy course was completed at the planned total  dose of 54 Gy. Acute skin and mucosal toxicity not more than Grade 2 (RTOG scale) was noted during the  treatment. A good partial response was recorded after chemoradiotherapy course had been finished.  Histological verification of UPS diagnosis is complicated as substantial amount of tumor tissue material is  required for immunohistochemical and cytogenetical studies. An aggressive surgical approach is a method  of choice for local control in parameningeal soft-tissue sarcomas. However the adaptive radiotherapy was  the only possible treatment method of local tumor control with significant decrease of high doses to adjacent normal organs and tissues.

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