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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">547</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2021-20-3-92-101</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Intracranial hemorrhages in children with immune thrombocytopenia</article-title><trans-title-group xml:lang="ru"><trans-title>Внутричерепные кровоизлияния у детей с иммунной тромбоцитопенией</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8404-1800</contrib-id><name-alternatives><name xml:lang="en"><surname>Suntsova</surname><given-names>E. V.</given-names></name><name xml:lang="ru"><surname>Сунцова</surname><given-names>Е. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><bold>Elena V. Suntsova</bold>, a Researcher at the Department of Depression of Hematopoiesis, Myeloid Leukemia, Rare and Hereditary Diseases</p><p>1 Samory Mashela St., Moscow 117997 </p></bio><bio xml:lang="ru"><p><bold>Сунцова Елена Викторовна</bold>, научный сотрудник отдела депрессий кроветворения, миелоидных лейкозов, редких и наследственных болезней</p><p>117997, Москва, ул. Саморы Машела, 1</p></bio><email>elena.suncova@fccho-moscow.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7918-680X</contrib-id><name-alternatives><name xml:lang="en"><surname>Sadovskaya</surname><given-names>M. N.</given-names></name><name xml:lang="ru"><surname>Садовская</surname><given-names>М. Н.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Moscow</p></bio><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3918-6781</contrib-id><name-alternatives><name xml:lang="en"><surname>Spichak</surname><given-names>O. V.</given-names></name><name xml:lang="ru"><surname>Спичак</surname><given-names>О. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Nizhnevartovsk</p></bio><bio xml:lang="ru"><p>Нижневартовск</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7891-402X</contrib-id><name-alternatives><name xml:lang="en"><surname>Ozerov</surname><given-names>S. S.</given-names></name><name xml:lang="ru"><surname>Озеров</surname><given-names>C. C.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Moscow</p></bio><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0782-3726</contrib-id><name-alternatives><name xml:lang="en"><surname>Khomyakova</surname><given-names>S. P.</given-names></name><name xml:lang="ru"><surname>Хомякова</surname><given-names>С. П.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Moscow</p></bio><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1897-5335</contrib-id><name-alternatives><name xml:lang="en"><surname>Pishchayeva</surname><given-names>N. Yu.</given-names></name><name xml:lang="ru"><surname>Пищаева</surname><given-names>Н. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Nizhnevartovsk</p></bio><bio xml:lang="ru"><p>Нижневартовск</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0813-5626</contrib-id><name-alternatives><name xml:lang="en"><surname>Kalinina</surname><given-names>I. I.</given-names></name><name xml:lang="ru"><surname>Калинина</surname><given-names>И. И.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Moscow</p></bio><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1881-7444</contrib-id><name-alternatives><name xml:lang="en"><surname>Kazaryan</surname><given-names>G. R.</given-names></name><name xml:lang="ru"><surname>Казарян</surname><given-names>Г. Р.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Nizhnevartovsk</p></bio><bio xml:lang="ru"><p>Нижневартовск</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6009-8095</contrib-id><name-alternatives><name xml:lang="en"><surname>Shako</surname><given-names>I. D.</given-names></name><name xml:lang="ru"><surname>Шако</surname><given-names>И. Д.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Nizhnevartovsk</p></bio><bio xml:lang="ru"><p>Нижневартовск</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0016-6698</contrib-id><name-alternatives><name xml:lang="en"><surname>Maschan</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Масчан</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Moscow</p></bio><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2322-5734</contrib-id><name-alternatives><name xml:lang="en"><surname>Novichkova</surname><given-names>G. A.</given-names></name><name xml:lang="ru"><surname>Новичкова</surname><given-names>Г. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Moscow</p></bio><bio xml:lang="ru"><p>Москва</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Regional Children’s Hospital</institution></aff><aff><institution xml:lang="ru">БУ ХМАО–Югры «Нижневартовская окружная клиническая детская больница»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-10-08" publication-format="electronic"><day>08</day><month>10</month><year>2021</year></pub-date><volume>20</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>92</fpage><lpage>101</lpage><history><date date-type="received" iso-8601-date="2021-10-08"><day>08</day><month>10</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-10-08"><day>08</day><month>10</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/547">https://hemoncim.com/jour/article/view/547</self-uri><abstract xml:lang="en"><p>Primary immune thrombocytopenia is a benign and self-limiting process in the majority of children. Severe life-threatening hemorrhages, including intracranial, develop rarely. Risk factors predisposing for development of severe hemorrhagic complications have not been determined. In order to decrease the severity of neurological consequences and mortality in intracranial hemorrhages, timely combined urgent therapy is neсessary. There are four clinical cases of intracranial hemorrhage in immune thrombocytopenia in children with different outcomes in this article. The parents of the patients agreed to use the information, including photos of children, in scientific research and publications.</p></abstract><trans-abstract xml:lang="ru"><p>Первичная иммунная тромбоцитопения у большинства детей является доброкачественным и самоограниченным процессом. Тяжелые, угрожающие жизни состояния, в том числе внутричерепные кровоизлияния, у детей развиваются редко. Факторы риска, предрасполагающие к развитию тяжелых геморрагических осложнений, не определены. В целях сокращения тяжести неврологических последствий и летальности при внутричерепных кровоизлияниях необходимо проведение своевременной комплексной неотложной терапии. В статье представлено 4 случая развития внутричерепного кровоизлияния при иммунной тромбоцитопении у детей с различными исходами. Родители пациентов дали согласие на использование информации, в том числе фотографий детей, в научных исследованиях и публикациях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>immune thrombocytopenia</kwd><kwd>intracranial hemorrhages</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>иммунная тромбоцитопения</kwd><kwd>внутричерепные кровоизлияния</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Rodeghiero F., Stasi R., Gernsheimer T., Michel M., Provan D., Arnold D.M., et al. 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