Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children57310.24287/1726-1708-2021-20-4-185-190LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫThe role of platelets in tumor cell metastasisРоль тромбоцитов в распространении опухолевых метастазовhttps://orcid.org/0000-0001-5292-2312YakushevaA. A.ЯкушеваА. А.
Russian Federation

a junior researcher at the Laboratory of Primary Hemostasis and Thrombosis,

1 Samory Mashela St., Moscow 117997

младший научный сотрудник лаборатории клеточного гемостаза и тромбоза,

117997, Москва, ул. Саморы Машела, 1

aa.yakusheva@physics.msu.ruhttps://orcid.org/0000-0002-0448-3981FilkovaA. A.ФильковаА. А.
Russian Federation

1 Samory Mashela St., Moscow 117997

117997, Москва, ул. Саморы Машела, 1

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииCenter for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of SciencesФГБУН Центр теоретических проблем физико-химической фармакологии РАН221220212041851902212202122122021Copyright ©; 2021, «D. Rogachev NMRCPHOI»Copyright ©; 2021, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2021«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/573

Platelets are small, nuclear-free cells whose main function is to stop bleeding. In addition to performing a hemostatic function, platelets are also involved in immune and inflammatory processes. Extensive experimental data suggest that platelets support tumor metastasis and their activation plays a critical role in cancer progression. In the circulatory system, platelets protect tumor cells from immune elimination and promote their arrest at the endothelium, supporting the formation of secondary lesions. Due to the significant contribution of platelets to tumor cells survival and propagation, antithrombotic drugs are considered as a novel anti-metastasis approach. In this article, the authors set a goal to summarize and update the currently existing knowledge about the molecular mechanisms and the role of platelets-tumor cells interaction, as well as to discuss the possibility of platelets receptors as anti-metastasis targets. 

Тромбоциты – это небольшие безъядерные клетки, основная функция которых – обеспечивать остановку кровотечений. Помимо выполнения гемостатической функции тромбоциты также задействованы в иммунных и воспалительных процессах. Обширные экспериментальные данные показывают, что тромбоциты поддерживают метастазирование опухолей и их активация играет решающую роль в прогрессировании рака. В системе кровообращения тромбоциты защищают опухолевые клетки от иммунной элиминации и способствуют их задержке в эндотелии, поддерживая образование вторичных поражений. За счет серьезного вклада тромбоцитов в выживаемость и распространение опухолевых клеток антитромботические препараты рассматриваются как новый метод борьбы с метастазированием опухолей. В этой статье авторы поставили перед собой цель обобщить и актуализировать существующие на данный момент знания о молекулярных механизмах взаимодействия тромбоцитов с опухолевыми клетками и роли данного процесса, а также обсудить возможность лечения онкологических заболеваний на основе антитромботической терапии. 

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