Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children6410.24287/1726-1708-2017-16-3-23-27СтатьиMRI T2*-mapping for liver iron assessment in pediatric patients with secondary iron overloadМетодика проведения Т2*-картирования печени у пациентов с вторичной перегрузкой железомhttps://orcid.org/0000-0002-0014-9345NazarovaE. E.НазароваЭ.Э.
Russian Federation

research assistant, radiology. Department of information technologies’   development

Russia 117997, Moscow, Samory Mashela st., 1 Tel.: +7 (495) 287-6570, ext. 1223

лаборант-исследователь отделения лучевой диагностики

117997, Москва, ГСП-7, ул. Саморы Машела, 1 Тел.: 8 (495) 287-6570, доб. 1223

evelina.nazarova@fcchomoscow.ruhttps://orcid.org/0000-0001-7317-7104TereshchenkoG. V.ТерещенкоГ.В.
Russian Federation
https://orcid.org/0000-0003-2622-9201AbakumovM. A.АбакумовМ.А.
Russian Federation

Department of Hematology

SmantserV. A.СманцерВ. А.
Russian Federation
https://orcid.org/0000-0002-5662-896XKupriyanovD. A.КуприяновД. А.
Russian Federation
https://orcid.org/0000-0002-8805-1499SmetaninaN. S.СметанинаН.С.
Russian Federation

Department of Hematology

Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, МоскваOncology and radiotherapy Russian National Research Medical University named after N.I. PirogovФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, МоскваDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation Philips HealthcareФилипс Здравоохранение, МоскваФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, МоскваDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian Federation Oncology and radiotherapy Russian National Research Medical University named after N.I. PirogovФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России, МоскваФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, Москва10082017163232710082018Copyright ©; 2017, «D. Rogachev NMRCPHOI»Copyright ©; 2017, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2017«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/64

Iron accumulation assessment in the body is important for iron overload determination in parenchymal organs and also necessary for planning and monitoring the chelation therapy. In this article, we  demonstrate non-invasive diagnostics of iron accumulation in the liver using magnetic resonance imaging.  MRI investigation includes 55 patients (2–18 years, median 8 years) with secondary iron overload due to  regular blood transfusions. Image analysis was conducted by special program of signal decay evaluation for  automatically T2* values calculation in liver. We have received a linear regression equation between the  biopsy data and T2* values and have obtained the grading system of T2* values based on siderosis grades.  Non-invasive MRI diagnostics in patients with iron overload can introduce new approaches for quantitative estimation of body iron deposition.

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