Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children64910.24287/1726-1708-2022-21-3-13-21ORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИUnstable abnormal hemoglobins found in Russia in the past 10 yearsАномальные нестабильные гемоглобины, идентифицированные в России за последние 10 летhttps://orcid.org/0000-0003-4222-2915LokhmatovaM. E.ЛохматоваМ. Е.
Russian Federation

Marina E. Lokhmatova, Cand. Med. Sci., a hematologist, Headof the Outpatient Clinic

1 Samory Mashela St., 117997, Moscow, Russia

Лохматова Марина Евгеньевна, канд. мед. наук, врач-гематолог, заведующая консультативным отделением

117997, Москва, ул. Саморы Машела, 1

marina.lokhmatova@fccho-moscow.ruhttps://orcid.org/0000-0002-1021-7348SokolovaN. E.СоколоваН. Е.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0002-0929-4792KrasilnikovaM. V.КрасильниковаМ. В.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0002-6331-5339LitvinE. A.ЛитвинЕ. А.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0002-9865-527XKaramjanN. A.КарамянН. А.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0002-1014-5196MannS. G.МаннС. Г.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0002-4503-0735PlyasunovaS. A.ПлясуноваС. А.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0003-2756-7325SmetaninaN. S.СметанинаН. С.
Russian Federation

Moscow

Москва

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России1510202221313211010202210102022Copyright ©; 2022, «D. Rogachev NMRCPHOI»Copyright ©; 2022, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2022«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/649

From 2010 to 2020, we investigated 197 children with hemolytic anemia of unknown etiology at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. Fifty-four of them were found to have hemoglobinopathy caused by unstable abnormal hemoglobins: Hb Monroe/Kairouan, Hb Tacoma, Hb Köln/SanFrancisco, Hb Cheverly, Hb City of Hope, Hb Southampton/Casper, Hb M-Hyde Park/Akita/Milwaukee-2, Hb Buenos Aires/Bryn Mawr, Hb Louisville/Bucureşti, Hb Genova/Hyogo, Hb Roseau-Pointe a Pitre, Hb Bristol/Alesha, Hb Henri Mondor, Hb Knossos, Hb Leiden, Hb Little Venice, Hb Olmsted, Hb Sabine, Hb Showa-Yakushiji, Hb Terre Haute, Hb Tübingen, Hb Quin-Hai. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation. The patients' parents signed the informed consent for molecular genetic testing and gave their consent to the use of their children's data, including photographs, for research purposes and in publications.

С 2010 по 2020 г. включительно в ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России обследованы 197 детей с гемолитической анемией неустановленной этиологии, у 54 из них выявлена гемоглобинопатия, обусловленная аномальным нестабильным гемоглобином: Hb Monroe/Kairouan, Hb Tacoma, Hb Köln/SanFrancisco, Hb Cheverly, Hb City of Hope, Hb Southampton/Casper, Hb M-Hyde Park/Akita/Milwaukee-2, Hb Buenos Aires/Bryn Mawr, Hb Louisville/Bucureşti, Hb Genova/Hyogo, Hb Roseau-Pointe a Pitre, Hb Bristol/Alesha, Hb Henri Mondor, Hb Knossos, Hb Leiden, Hb Little Venice, Hb Olmsted, Hb Sabine, Hb Showa-Yakushiji, Hb Terre Haute, Hb Tübingen, Hb Quin-Hai. Данное исследование одобрено независимым этическим комитетом и утверждено решением ученого совета НМИЦ ДГОИ им. Дмитрия Рогачева. Родители пациентов подписали информированное согласие на проведение молекулярно-генетического исследования и дали свое разрешение использовать персональные данные и фотографии детей в научных исследованиях и публикациях.

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