Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children6610.24287/1726-1708-2017-16-3-35-47СтатьиImplementation of the algorithm of empirical antibacterial therapy for febrile neutropenia in the Сenter of pediatric hematology/oncologyОпыт внедрения алгоритма эмпирической антибактериальной терапии при развитии фебрильной нейтропении в Центре детской гематологии/онкологииSolopovaG. G.СолоповаГ. Г.
Russian Federation

MD, PhD, head of infection prevention & control department

Russia 117997, Moscow, Samory Mashela st., 1 Tel.: +7 (495) 287-6570, ext. 1345

канд. мед. наук, заведующая отделением инфекционного контроля

117997, Москва, ГСП-7, ул. Саморы Машела, 1 Тел.: 8 (495) 287-6570, доб. 1345

galina.solopova@fcchomoscow.ruhttps://orcid.org/0000-0002-2322-5734NovichkovaG. A.НовичковаГ. А.
Russian Federation
Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, Москва10082017163354710082018Copyright ©; 2017, «D. Rogachev NMRCPHOI»Copyright ©; 2017, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2017«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/66

Febrile neutropenia is a life-threatening condition that requires the immediate administration of broad-spectrum antibiotics. On the other hand, the most serious problem of medicine is the continuously growing  resistance of microorganisms to antibiotics. It is known that the main reason for this phenomenon is the  irrational and excessive use of antibacterial drugs in the hospital. To make treatment of infectious  complications more effective, optimize use of antibiotics and reduce resistance of microorganisms in Dmitry  Rogachev National Research Center of Pediatric Hematology, Oncology and Immunology (Center) the  algorithm for empirical antibacterial therapy of febrile neutropenia was developed. Analysis of early results  showed a reduction in the consumption of all classes antibiotics in the intensive care unit (ICU) a year after  the start of the algorithm. After three years, it was possible to reduce the consumption of β-lactams,  fluoroquinolones and linezolid throughout the Center. When analyzing the level of resistance to antibiotics,  its decrease for such pathogens as Kl. pneumoniae, Ps. aeruginosae and Ent. Cloacae was revealed. To obtain other results of the algorithm, further detailed analysis is needed.

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