Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children69710.24287/1726-1708-2023-22-1-99-109CLINICAL OBSERVATIONSКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯRosai–Dorfman disease (sinus histiocytosis with massive lymphadenopathy): personal observations and literature reviewБолезнь Розаи–Дорфмана (синусовый гистиоцитоз с массивной лимфоаденопатией). Собственное наблюдение и обзор литературыhttps://orcid.org/0000-0001-6628-0760RudnevaA. E.РудневаА. Е.
Russian Federation

Anastasiya E. Rudneva, a senior researcher at the Lymphoma Research Department

1 Samory Mashela St., Moscow 117997, Russia 

Руднева Анастасия Евгеньевна, старший научный сотрудник отдела исследования лимфом

117997, Москва, ул. Саморы Машела, 1

anastasija.rudneva@fccho-moscow.ruhttps://orcid.org/0000-0003-3664-2876AbramovD. S.АбрамовД. С.
Russian Federation

Moscow

 Москва 

https://orcid.org/0000-0001-5354-7067SharlayA. S.ШарлайА. С.
Russian Federation

Moscow

 Москва 

https://orcid.org/0000-0002-6158-2222LikarYu. N.ЛикарьЮ. Н.
Russian Federation

Moscow

 Москва 

https://orcid.org/0000-0002-3932-6257VorozhtsovI. N.ВорожцовИ. Н.
Russian Federation

Moscow

 Москва 

https://orcid.org/0000-0002-4779-1896MyakovaN. V.МяковаН. В.
Russian Federation

Moscow

 Москва 

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthсare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России01032023221991091402202228022023Copyright ©; 2023, «D. Rogachev NMRCPHOI»Copyright ©; 2023, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2023«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/697

Rosai–Dorfman disease (RDD) is a rare histiocytic disorder, which occurs at any age, can affect almost any organs and tissues, does not have pathognomonic symptoms and could be confirmed only by histological examination of the affected tissue. The article describes the successful treatment of a child with RDD with lymph nodes, nasopharynx, subcutaneous tissue, spleen and bones involvement, by multistep surgical treatment and chemotherapy. A review of the literature is provided, including recommendations for the examination and treatment of patients with RDD. The patient's parents agreed to use the information, including the child's photo, in scientific research and publications.

Болезнь Розаи–Дорфмана (БРД) – редкое заболевание из группы гистиоцитозов, которое встречается в любом возрасте, может поражать практически любые органы и ткани, не имеет патогномоничных симптомов и подтверждается только при гистологическом исследовании пораженной ткани. В работе приводится описание успешного лечения ребенка с БРД с поражением лимфатических узлов, носоглотки, подкожной клетчатки, селезенки и костей, включавшего многоэтапное хирургическое вмешательство и химиотерапию, а также представлен обзор литературы, содержащий рекомендации по обследованию и лечению пациентов с БРД. Родители пациента дали согласие на использование информации, в том числе фотографий ребенка, в научных исследованиях и публикациях.

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