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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">702</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2023-22-1-147-151</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Heart failure as a manifestation of acute lymphoblastic leukemia</article-title><trans-title-group xml:lang="ru"><trans-title>Сердечная недостаточность как проявление острого лимфобластного лейкоза</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3247-8688</contrib-id><name-alternatives><name xml:lang="en"><surname>Anderzhanova</surname><given-names>L. Kh.</given-names></name><name xml:lang="ru"><surname>Андержанова</surname><given-names>Л. Х.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p><bold>Lilia Kh. Anderzhanova</bold>, a hematologist at the Oncohematology Department </p><p>1 Samory Mashela St., Moscow 117997, Russia </p></bio><bio xml:lang="ru"><p><bold> </bold><bold>Андержанова Лилия Халитовна</bold>, врач-гематолог отделения онкогематологии117997, Москва, ул. Саморы Машела, 1</p></bio><email>anderliliya@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rybalko</surname><given-names>N. A.</given-names></name><name xml:lang="ru"><surname>Рыбалко</surname><given-names>Н. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p> Moscow </p></bio><bio xml:lang="ru"><p> Москва </p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shatsky</surname><given-names>M. A.</given-names></name><name xml:lang="ru"><surname>Шатский</surname><given-names>М. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p> Moscow </p></bio><bio xml:lang="ru"><p> Москва </p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tikhomirova</surname><given-names>E. A.</given-names></name><name xml:lang="ru"><surname>Тихомирова</surname><given-names>Е. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p> Moscow </p></bio><bio xml:lang="ru"><p> Москва </p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4779-1896</contrib-id><name-alternatives><name xml:lang="en"><surname>Myakova</surname><given-names>N. V.</given-names></name><name xml:lang="ru"><surname>Мякова</surname><given-names>Н. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p> Moscow </p></bio><bio xml:lang="ru"><p> Москва </p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">The Morozov Children's Clinical Hospital of the Department of Health of Moscow</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Морозовская детская городская клиническая больница Департамента здравоохранения г. Москвы»</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2023-03-01" publication-format="electronic"><day>01</day><month>03</month><year>2023</year></pub-date><volume>22</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>147</fpage><lpage>151</lpage><history><date date-type="received" iso-8601-date="2022-11-21"><day>21</day><month>11</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2023-03-01"><day>01</day><month>03</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/702">https://hemoncim.com/jour/article/view/702</self-uri><abstract xml:lang="en"><p>Clinically significant myocardial infiltration by blast cells is a rare occurrence in acute leukemia. Heart failure rate in children with hemato-oncological diseases is unknown. Here we report a clinical case of an 8-year-old female patient with B-cell acute lymphoblastic leukemia as well as heart failure that resolved during specific therapy for the cancer. The patient's parents gave consent to the use of their child's data, including photographs, for research purposes and in publications.</p></abstract><trans-abstract xml:lang="ru"><p>Клинически значимая инфильтрация миокарда бластными клетками при остром лейкозе встречается редко. Частота поражения сердца при онкогематологических заболеваниях у детей неизвестна. В данной статье представлено описание клинического случая пациентки 8 лет с В-клеточным острым лимфобластным лейкозом c сердечной недостаточностью, которая разрешилась на фоне специфической терапии злокачественного заболевания. Родители пациентки дали согласие на использование информации, в том числе фотографий ребенка, в научных исследованиях и публикациях.</p></trans-abstract><kwd-group xml:lang="en"><kwd>acute leukemia</kwd><kwd>blast cell infiltration</kwd><kwd>children</kwd><kwd>heart failure</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>острый лейкоз</kwd><kwd>инфильтрация бластными клетками</kwd><kwd>дети</kwd><kwd>сердечная недостаточность</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Hunkeler N., Canter C.E. Antemortem diagnosis of gross cardiac metastasis in childhood leukemia: echocardiographic demonstration. Pediatr cardiol 1990; 11 (4): 225–6.</mixed-citation><mixed-citation xml:lang="ru">Hunkeler N., Canter C.E. Antemortem diagnosis of gross cardiac metastasis in childhood leukemia: echocardiographic demonstration. Pediatr cardiol 1990; 11 (4): 225–6.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Cheng H., Feldman T., Butt Y., Chow K.F., Yang X.Y., Bhattacharyya P.K., et al. T-cell prolymphocytic leukemia with extensive cardiovascular infiltrate leading to multiple myocardial infarctions and cardiac death. Tex Heart Inst J 2014; 41 (6): 626–30.</mixed-citation><mixed-citation xml:lang="ru">Cheng H., Feldman T., Butt Y., Chow K.F., Yang X.Y., Bhattacharyya P.K., et al. T-cell prolymphocytic leukemia with extensive cardiovascular infiltrate leading to multiple myocardial infarctions and cardiac death. Tex Heart Inst J 2014; 41 (6): 626–30.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Sanchez-Correa B., Bergua J. M., Campos C., Gayoso I., Arcos M.J., Bañas H., et al. Cytokine profiles in acute myeloid leukemia patients at diagnosis: survival is inversely correlated with IL-6 and directly correlated with IL-10 levels. Cytokine 2013; 61(3): 885–91.</mixed-citation><mixed-citation xml:lang="ru">Sanchez-Correa B., Bergua J. M., Campos C., Gayoso I., Arcos M.J., Bañas H., et al. Cytokine profiles in acute myeloid leukemia patients at diagnosis: survival is inversely correlated with IL-6 and directly correlated with IL-10 levels. Cytokine 2013; 61(3): 885–91.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Tsimberidou A.M., Estey E., Wen S., Pierce S., Kantarjian H., Albitar M., et al. The prognostic significance of cytokine levels in newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndromes. Cancer 2008; 113 (7): 1605–13.</mixed-citation><mixed-citation xml:lang="ru">Tsimberidou A.M., Estey E., Wen S., Pierce S., Kantarjian H., Albitar M., et al. The prognostic significance of cytokine levels in newly diagnosed acute myeloid leukemia and high-risk myelodysplastic syndromes. Cancer 2008; 113 (7): 1605–13.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Kalogeropoulos A.P., Georgiopoulou V.V., Butler J. From risk factors to structural heart disease: the role of inflammation. Heart Fail Clin 2012; 8: 113–23.</mixed-citation><mixed-citation xml:lang="ru">Kalogeropoulos A.P., Georgiopoulou V.V., Butler J. From risk factors to structural heart disease: the role of inflammation. Heart Fail Clin 2012; 8: 113–23.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Sumners J.E., Johnson W.W., Ainger L.E. Childhood leukemic heart disease. A study of 116 hearts of children dying of leukemia. Circulation 1969; 40 (4): 575–81.</mixed-citation><mixed-citation xml:lang="ru">Sumners J.E., Johnson W.W., Ainger L.E. Childhood leukemic heart disease. A study of 116 hearts of children dying of leukemia. Circulation 1969; 40 (4): 575–81.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Roberts W.C., Bodey G.P., Wertlake P.T. The heart in acute leukemia. A study of 420 autopsy cases. Am J Cardiol 1968; 21 (3): 388–412.</mixed-citation><mixed-citation xml:lang="ru">Roberts W.C., Bodey G.P., Wertlake P.T. The heart in acute leukemia. A study of 420 autopsy cases. Am J Cardiol 1968; 21 (3): 388–412.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Klatt E.C., Heitz D.R. Cardiac metastases. Cancer 1990; 65 (6): 1456–9.</mixed-citation><mixed-citation xml:lang="ru">Klatt E.C., Heitz D.R. Cardiac metastases. Cancer 1990; 65 (6): 1456–9.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Prenner S.B., Franken A.A., Murphy I.G., Mikati I.A. Rapid Reversal of Focal Left Ventricular Hypertrophy and Systolic Dysfunction Resulting From Myocardial Infiltration by Acute Lymphoblastic Leukemia. Circulation 2016; 133 (7): 678–9.</mixed-citation><mixed-citation xml:lang="ru">Prenner S.B., Franken A.A., Murphy I.G., Mikati I.A. Rapid Reversal of Focal Left Ventricular Hypertrophy and Systolic Dysfunction Resulting From Myocardial Infiltration by Acute Lymphoblastic Leukemia. Circulation 2016; 133 (7): 678–9.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. De Lazzari M., Fedrigo M., Perazzolo Marra M., Calabrò F., Tarantini G., D'Amore E.G., et аl. Relapsing Leukemia Infiltrating the Heart. Circ Heart Fail 2015; 8 (6): 1133–4.</mixed-citation><mixed-citation xml:lang="ru">De Lazzari M., Fedrigo M., Perazzolo Marra M., Calabrò F., Tarantini G., D'Amore E.G., et аl. Relapsing Leukemia Infiltrating the Heart. Circ Heart Fail 2015; 8 (6): 1133–4.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Barbaric D., Holley D., Lau K.C., McCowage G. It is ALL in the heart: a patient with acute lymphoblastic leukemia and cardiac infiltration at time of diagnosis. Leuk Lymphoma 2002; 43 (12): 2417–9.</mixed-citation><mixed-citation xml:lang="ru">Barbaric D., Holley D., Lau K.C., McCowage G. It is ALL in the heart: a patient with acute lymphoblastic leukemia and cardiac infiltration at time of diagnosis. Leuk Lymphoma 2002; 43 (12): 2417–9.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Assuncao B.M.B.L., Handschumacher M.D., Brunner A.M., Yucel E., Bartko P.E., Cheng K.H., еt al. Acute Leukemia is Associated with Cardiac Alterations before Chemotherapy. J Am Soc Echocardiogr 2017; 30 (11): 1111–8.</mixed-citation><mixed-citation xml:lang="ru">Assuncao B.M.B.L., Handschumacher M.D., Brunner A.M., Yucel E., Bartko P.E., Cheng K.H., еt al. Acute Leukemia is Associated with Cardiac Alterations before Chemotherapy. J Am Soc Echocardiogr 2017; 30 (11): 1111–8.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Mulrooney D.A., Yeazel M.W., Kawashima T., Mertens A.C., Mitby P., Stovall M., et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ 2009; 339: b4606.</mixed-citation><mixed-citation xml:lang="ru">Mulrooney D.A., Yeazel M.W., Kawashima T., Mertens A.C., Mitby P., Stovall M., et al. Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort. BMJ 2009; 339: b4606.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Jung M.H., Lee Y.H., Lee K.Y., Jung H.O., Youn H.J. Leukemic infiltration presenting as myocardial hypertrophy after complete remission of acute myeloid leukemia. Echocardiography 2017; 34 (1): 136–8.</mixed-citation><mixed-citation xml:lang="ru">Jung M.H., Lee Y.H., Lee K.Y., Jung H.O., Youn H.J. Leukemic infiltration presenting as myocardial hypertrophy after complete remission of acute myeloid leukemia. Echocardiography 2017; 34 (1): 136–8.</mixed-citation></citation-alternatives></ref></ref-list></back></article>
