Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children7110.24287/1726-1708-2017-16-3-69-72СтатьиDynamics of platelet functional activity and hemostatic status in a child with chronic immune thrombocytopenia on romiplostim treatmentДинамика функциональной активности тромбоцитов и гемостатического статуса у ребенка с хронической иммунной тромбоцитопенией на терапии ромиплостимомhttps://orcid.org/0000-0001-8404-1800SuntsovaE. V.СунцоваЕ.В.
Russian Federation

Russia 117997, Moscow, Samory Mashela st., 1

IgnatovaA. A.ИгнатоваА.А.
Russian Federation

Russia 117997, Moscow, Samory Mashela st., 1

https://orcid.org/0000-0002-2057-2036PshonkinA. V.ПшонкинА.В.
Russian Federation

Russia 117997, Moscow, Samory Mashela st., 1

SerkovaI. V.СерковаИ.В.
Russian Federation

Russia 117997, Moscow, Samory Mashela st., 1

MaschanA. A.МасчанА.А.
Russian Federation

Russia 117997, Moscow, Samory Mashela st., 1

https://orcid.org/0000-0002-2322-5734NovichkovaG. A.НовичковаГ.А.
Russian Federation

Russia 117997, Moscow, Samory Mashela st., 1

https://orcid.org/0000-0002-8128-7757PanteleevM. A.ПантелеевМ.А.
Russian Federation

PhD, DSc, Head of the Laboratory of cellular hemostasis and trombosis

Russia 117997, Moscow, Samory Mashela st., 1

+7 (495) 287-6570, ext. 6932

mapanteleev@yandex.ruDmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology Ministry of Healthcare of Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, Москва10082017163697210082018Copyright ©; 2017, «D. Rogachev NMRCPHOI»Copyright ©; 2017, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2017«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/71

Immune thrombocytopenia (ITP) is characterized by changes in both quantity and quality of platelets. As a result, severity of bleeding does not always correllate with the degree of thrombocytopenia, The quality of platelets on treatment becomes difficult to evaluate. The most promising method to investigate quality of platelets in ITP is flow cytometry. Here we describe a clinical case of monitoring of a pediatric ITP patient status on romiplostim treatment for 50 weeks using flow cytometry for platelet functional activity control.

Иммунная тромбоцитопения (ИТП) характеризуется изменением как количества, так и качества тромбоцитов. В результате этого тяжесть кровотечений не всегда коррелирует со степенью тромбоцитопении. Если пациент находится на терапии, оценка качества тромбоцитов дополнительно усложняется. Наиболее многообещающим методом исследования тромбоцитов при ИТП является проточная цитометрия. В данном сообщении описан клинический случай наблюдения за динамикой состояния ребенка с хронической ИТП на терапии ромиплостимом в течение 50 недель с использованием проточной цитометрии для контроля функциональной активности тромбоцитов.

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