Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children73210.24287/1726-1708-2023-22-2-159-165LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫExtracorporeal photopheresis: how, why and for whom?Экстракорпоральный фотоферез: как, зачем и для кого?https://orcid.org/0000-0002-9881-1041KumukovaI. B.КумуковаИ. Б.
Russian Federation

Irina B. Kumukova, Cand. Med. Sci., researcher, Head of Unit

Department of Treatment and Prophylaxis Optimization for HSCT complications

Transfusion Unit

117997

1 Samory Mashela St.

Moscow

Ирина Борисовна Кумукова, канд. мед. наук, научный сотрудник, заведующая кабинетом

отдел оптимизации лечения и профилактики осложнений трансплантации гемопоэтических стволовых клеток

кабинет трансфузиологии

117997

ул. Саморы Машела, 1

Москва

irina.kumukova@fccho-moscow.ruhttps://orcid.org/0000-0002-0231-1617TrakhtmanP. E.ТрахтманП. Е.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0003-4767-5382KurnikovaE. E.КурниковаЕ. Е.
Russian Federation

Moscow

Москва

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииKommunarka Multidisciplinary Clinical Center of the Department of Health of MoscowГБУЗ «Московский многопрофильный клинический центр «Коммунарка» Департамента здравоохранения г. Москвы»080720232221591652811202224052023Copyright ©; 2025, «D. Rogachev NMRCPHOI»Copyright ©; 2025, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2025«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/732

   Extracorporeal photopheresis is a method of cell therapy that was developed and introduced into clinical practice of various specialties over 30 years ago but its mechanism of action, clinical application and the possibility of further modification are still on the minds of scientists around the world. Here we provide a review of the existing literature on the major critical aspects of the extracorporeal photopheresis technology as well as information on possible ways of modifying the method, the current understanding of its mechanism of effectiveness, the use in various diseases and pathological conditions and a list of possible side effects.

   Экстракорпоральный фотоферез – метод клеточной терапии, разработанный и внедренный в клиническую практику врачей различных специальностей уже более 30 лет назад, однако до сих пор механизм его действия, применение в клинической практике и возможность модификации занимают умы ученых по всему миру. В данной статье приведены обзор литературных данных по основным критически важным аспектам технологии выполнения экстракорпорального фотофереза, возможности модификации метода, современное понимание механизма эффективности, применение при различных заболеваниях и патологических состояниях, а также спектр побочныхэффектов.

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