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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">77</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2017-16-1-22-27</article-id><article-categories><subj-group subj-group-type="toc-heading"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Diagnostic procedure and choice of treatment of various forms of liver hemangiomas in children</article-title><trans-title-group xml:lang="ru"><trans-title>Алгоритм диагностики и выбор методов лечения различных форм гемангиом печени у детей</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Petrushin</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Петрушин</surname><given-names>А. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Head of the Department of Interventional Radiology</p><p>Russia 117997, Moscow, Samory Mashela st., 1</p><p> </p></bio><email>pantonu@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mylnikov</surname><given-names>A. A.</given-names></name><name xml:lang="ru"><surname>Мыльников</surname><given-names>А. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Garbuzov</surname><given-names>R. V.</given-names></name><name xml:lang="ru"><surname>Гарбузов</surname><given-names>Р. В.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Narbutov</surname><given-names>A. G.</given-names></name><name xml:lang="ru"><surname>Нарбутов</surname><given-names>А. Г.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Polyaev</surname><given-names>A. Yu.</given-names></name><name xml:lang="ru"><surname>Поляев</surname><given-names>А. Ю.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Polyaev</surname><given-names>Yu. A.</given-names></name><name xml:lang="ru"><surname>Поляев</surname><given-names>Ю. А.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><xref ref-type="aff" rid="aff5"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">National Reseach Practicle Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный научно-практический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, Москва</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">National Reseach Practicle Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry Rogachev&#13;
Russian Children’s Clinacal Hospital, Ministry of Health of Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российская детская клиническая больница» Минздрава России, Москва</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Russian Children’s Clinacal Hospital, Ministry of Health of Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российская детская клиническая больница» Минздрава России, Москва</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">City Clinical Hospital № 4 Moscow City Health Department</institution></aff><aff><institution xml:lang="ru">ГБУЗ «Городская клиническая больница № 4 Департамента здравоохранения города Москвы»</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Russian Children’s Clinacal Hospital, Ministry of Health of Russian Federation, Moscow&#13;
&#13;
Research Institute of pediatric surgery of Pirogov Russian Research Medical University, Ministry of Health of Russian Federation</institution></aff><aff><institution xml:lang="ru">ФГБУ «Российская детская клиническая больница» Минздрава России, Москва.  НИИ хирургии детского возраста ФГБОУ ВО «РНИМУ им. Н.И. Пирогова» Минздрава России, Москва</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-02-10" publication-format="electronic"><day>10</day><month>02</month><year>2017</year></pub-date><volume>16</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>22</fpage><lpage>27</lpage><history><date date-type="received" iso-8601-date="2018-08-10"><day>10</day><month>08</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/77">https://hemoncim.com/jour/article/view/77</self-uri><abstract xml:lang="en"><p>Liver tumor can be identified in the child from the first days of life, and sometimes in the prenatal period. It is very important to differentiate hemangiomas from vascular malformations, especially in the first year of life. Total in Russian Children’s Clinacal Hospital and Dmitry Rogachev Federal Research Center of Paediatric Hematology, Oncology and Immunology for the period 2004−2016 were examined and treated 90 children. The main method of diagnosis: MSCT, MRI, Doppler ultrasound, angiography. Focal form revealed in 52 children (58%), multifocal 32 (35%), diffuse 6 patients (7%). Treatment methods include: propranolol therapy, endovascular occlusion and surgery. The choice of method occurred based on the type hemangiomas and age of the patient. Therapy of β-blockers was held 61 (67%) child with various forms of hemangiomas of the liver at the age from 1 month to 1 year 2 months. Endovascular treatment performed 38 patients (42%) between the ages of 3 months to 5 years. Endovascular occlusion is performed using the 3 main types of occlusive materials: beads, cylinders and Gianturko spirals. Surgery performed 17 patients (19%), including 1 patient revealed diffuse, multifocal in 3 and 13 focal form. In the group of drug treatment initial response to therapy of β-blockers was obtained in all patients. In the second group, after performing endovascular occlusion of hemangiomas, the reduction of the size of formations with a reduction of blood flow in them, followed by a gradual devolution of formations was observed in all patients. Today catamnesis is 9 years old, relapse is not revealed. In the group of surgical re-operation was required in any case, the relapse of the pathological process is also not observed. Thus, in patients with hepatic hemangiomas expedient selection of the most conservative and minimally invasive treatment.</p></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>hepatic hemangioma</kwd><kwd>focal form</kwd><kwd>multifocal form</kwd><kwd>diffuse form</kwd><kwd>propranolol</kwd><kwd>endovascular occlusion</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гемангиома печени</kwd><kwd>монофокальная форма</kwd><kwd>мультифокальная форма</kwd><kwd>диффузная форма</kwd><kwd>пропранолол</kwd><kwd>эндоваскулярная окклюзия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">1. Поляев Ю.А., Нарбутов А.Г., Мыльников А.А., Гарбузов Р.В. Диагностика и лечение доброкачественных гиперваскулярных образований печени у детей. Российский вестник детской хирургии, анестезиологии и реаниматологии. 2014;1:25-33.</mixed-citation><mixed-citation xml:lang="ru">Поляев Ю.А., Нарбутов А.Г., Мыльников А.А., Гарбузов Р.В. Диагностика и лечение доброкачественных гиперваскулярных образований печени у детей. Российский вестник детской хирургии, анестезиологии и реаниматологии. 2014;1:25-33.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">2. Поляев Ю.А., Постников С.С., Мыльников А.А., Нарбутов А.Г. Место пропранолола в лечении инфантильных гемангиом. Детская больница. 2012;4:46-48.</mixed-citation><mixed-citation xml:lang="ru">Поляев Ю.А., Постников С.С., Мыльников А.А., Нарбутов А.Г. Место пропранолола в лечении инфантильных гемангиом. Детская больница. 2012;4:46-48.</mixed-citation></citation-alternatives></ref><ref id="B3"><label>3.</label><citation-alternatives><mixed-citation xml:lang="en">3. Boon L.M., Burrows P.E., Paltiel H.J., Lund D.P., Ezekowitz R.A., Folkman J. et al. Hepatic vascular anomalies in infancy: a twenty-seven-year experience. J Pediatr. 1996;129(3):346-354.</mixed-citation><mixed-citation xml:lang="ru">Boon L.M., Burrows P.E., Paltiel H.J., Lund D.P., Ezekowitz R.A., Folkman J. et al. Hepatic vascular anomalies in infancy: a twenty-seven-year experience. J Pediatr. 1996;129(3):346-354.</mixed-citation></citation-alternatives></ref><ref id="B4"><label>4.</label><citation-alternatives><mixed-citation xml:lang="en">4. Bosemani T., Puttgen K.B., Huisman T.A., Tekes A. Multifocal infantile hepatic hemangiomas-imaging strategy and response to treatment after propranolol and steroids including review of the literature. Eur J Pediatr. 2012;171(7):1023-1028.</mixed-citation><mixed-citation xml:lang="ru">Bosemani T., Puttgen K.B., Huisman T.A., Tekes A. Multifocal infantile hepatic hemangiomas-imaging strategy and response to treatment after propranolol and steroids including review of the literature. Eur J Pediatr. 2012;171(7):1023-1028.</mixed-citation></citation-alternatives></ref><ref id="B5"><label>5.</label><citation-alternatives><mixed-citation xml:lang="en">5. Burrows P.E., Dubois J., Kassarjian A. Pediatric hepatic vascular anomalies. Pediatr Radiol. 2001;31(8):533-545.</mixed-citation><mixed-citation xml:lang="ru">Burrows P.E., Dubois J., Kassarjian A. Pediatric hepatic vascular anomalies. Pediatr Radiol. 2001;31(8):533-545.</mixed-citation></citation-alternatives></ref><ref id="B6"><label>6.</label><citation-alternatives><mixed-citation xml:lang="en">6. Cavalli R., Novotna V., Buffon R.B., Gelmetti C. Multiple cutaneous and hepatic infantile hemangiomas having a successful response to propranolol as monotherapy at neonatal period. G Ital Dermatol Venereol. 2013;148(5):525-530.</mixed-citation><mixed-citation xml:lang="ru">Cavalli R., Novotna V., Buffon R.B., Gelmetti C. Multiple cutaneous and hepatic infantile hemangiomas having a successful response to propranolol as monotherapy at neonatal period. G Ital Dermatol Venereol. 2013;148(5):525-530.</mixed-citation></citation-alternatives></ref><ref id="B7"><label>7.</label><citation-alternatives><mixed-citation xml:lang="en">7. Chen H., Lin X., Jin Y., Fan X., Li W., Ma G. et al. Deep infantile hemangiomas and early venous malformations: Differential diagnosis by 3D CT angiography. Ann Plast Surg. 2010;64(6):755-758.</mixed-citation><mixed-citation xml:lang="ru">Chen H., Lin X., Jin Y., Fan X., Li W., Ma G. et al. Deep infantile hemangiomas and early venous malformations: Differential diagnosis by 3D CT angiography. Ann Plast Surg. 2010;64(6):755-758.</mixed-citation></citation-alternatives></ref><ref id="B8"><label>8.</label><citation-alternatives><mixed-citation xml:lang="en">8. Burrows P.E., Dubois J., Kassarjian A. Pediatric hepatic vascular anomalies. Pediatr Radiol. 2001;31(8):533-545.</mixed-citation><mixed-citation xml:lang="ru">Burrows P.E., Dubois J., Kassarjian A. Pediatric hepatic vascular anomalies. Pediatr Radiol. 2001;31(8):533-545.</mixed-citation></citation-alternatives></ref><ref id="B9"><label>9.</label><citation-alternatives><mixed-citation xml:lang="en">9. Dubois J., Garel L., Grignon A., David M., Laberge L., Filiatrault D. et al. Imaging of hemangiomas and vascular malformations in children. Acad Radiol. 1998;5(5):390-400.</mixed-citation><mixed-citation xml:lang="ru">Dubois J., Garel L., Grignon A., David M., Laberge L., Filiatrault D. et al. Imaging of hemangiomas and vascular malformations in children. Acad Radiol. 1998;5(5):390-400.</mixed-citation></citation-alternatives></ref><ref id="B10"><label>10.</label><citation-alternatives><mixed-citation xml:lang="en">10. McLean R.H., Moller J.H., Warwick W.J., Satran L., Lucas R.V. Jr. Multinodular hemangiomatosis of the liver in infancy. Pediatrics. 1972;49:563-573.</mixed-citation><mixed-citation xml:lang="ru">McLean R.H., Moller J.H., Warwick W.J., Satran L., Lucas R.V. Jr. Multinodular hemangiomatosis of the liver in infancy. Pediatrics. 1972;49:563-573.</mixed-citation></citation-alternatives></ref><ref id="B11"><label>11.</label><citation-alternatives><mixed-citation xml:lang="en">11. Erbay A., Sarialioglu F., Malbora B., Yildirim S.V., Varan B., Tarcan A. et al. Propranolol for infantile haemangiomas: a preliminary report on efficacy and safety in very low birthweight infants. Turk J Pediatr. 2010;52(5):450-456.</mixed-citation><mixed-citation xml:lang="ru">Erbay A., Sarialioglu F., Malbora B., Yildirim S.V., Varan B., Tarcan A. et al. Propranolol for infantile haemangiomas: a preliminary report on efficacy and safety in very low birthweight infants. Turk J Pediatr. 2010;52(5):450-456.</mixed-citation></citation-alternatives></ref><ref id="B12"><label>12.</label><citation-alternatives><mixed-citation xml:lang="en">12. Holmdahl K. Cutaneous hemangiomas in premature and mature infants. Acta Paediatr. 1955;44(4):370-379.</mixed-citation><mixed-citation xml:lang="ru">Holmdahl K. Cutaneous hemangiomas in premature and mature infants. Acta Paediatr. 1955;44(4):370-379.</mixed-citation></citation-alternatives></ref><ref id="B13"><label>13.</label><citation-alternatives><mixed-citation xml:lang="en">13. Ishak K.G., Goodman Z.D., Stocker J.T. Benign mesenchymal tumors and pseudotumors. In: Rosai J., Sobin L., eds. Atlas of tumor pathology: tumors of the liver and intrahepatic bile ducts. Washington, DC: Armed Forces Institute of Pathology; 2001:71-157.</mixed-citation><mixed-citation xml:lang="ru">Ishak K.G., Goodman Z.D., Stocker J.T. Benign mesenchymal tumors and pseudotumors. In: Rosai J., Sobin L., eds. Atlas of tumor pathology: tumors of the liver and intrahepatic bile ducts. Washington, DC: Armed Forces Institute of Pathology; 2001:71-157.</mixed-citation></citation-alternatives></ref><ref id="B14"><label>14.</label><citation-alternatives><mixed-citation xml:lang="en">14. Kassarjian A., Zurakowski D., Dubois J., Paltiel H.J., Fishman S.J., Burrows P.E. Infantile hepatic hemangiomas: clinical and imaging findings and their correlation with therapy. AJR Am J Roentgenol. 2004;182(3):785-795.</mixed-citation><mixed-citation xml:lang="ru">Kassarjian A., Zurakowski D., Dubois J., Paltiel H.J., Fishman S.J., Burrows P.E. Infantile hepatic hemangiomas: clinical and imaging findings and their correlation with therapy. AJR Am J Roentgenol. 2004;182(3):785-795.</mixed-citation></citation-alternatives></ref><ref id="B15"><label>15.</label><citation-alternatives><mixed-citation xml:lang="en">15. Mason K.P., Koka B.V., Eldredge E.A., Fishman S.J., Burrows P.E. Perioperative considerations in a hypothyroid infant with hepatic haemangioma. Paediatr Anaesth. 2001;11(2):228-232.</mixed-citation><mixed-citation xml:lang="ru">Mason K.P., Koka B.V., Eldredge E.A., Fishman S.J., Burrows P.E. Perioperative considerations in a hypothyroid infant with hepatic haemangioma. Paediatr Anaesth. 2001;11(2):228-232.</mixed-citation></citation-alternatives></ref><ref id="B16"><label>16.</label><citation-alternatives><mixed-citation xml:lang="en">16. Zhang Z., Chen H.J., Yang W.J., Bu H., Wei B., Long X.Y. et al. Infantile hepatic hemangioendothelioma in a Chinese population. World J Gastroenterol. 2010;16(36):4549-4557.</mixed-citation><mixed-citation xml:lang="ru">Zhang Z., Chen H.J., Yang W.J., Bu H., Wei B., Long X.Y. et al. Infantile hepatic hemangioendothelioma in a Chinese population. World J Gastroenterol. 2010;16(36):4549-4557.</mixed-citation></citation-alternatives></ref><ref id="B17"><label>17.</label><citation-alternatives><mixed-citation xml:lang="en">17. Mhanna A., Franklin W.H., Mancini A.J. Hepatic infantile hemangiomas treated with oral propranolol - а case series. Pediatr Dermatol. 2011;28(1):39-45.</mixed-citation><mixed-citation xml:lang="ru">Mhanna A., Franklin W.H., Mancini A.J. Hepatic infantile hemangiomas treated with oral propranolol - а case series. Pediatr Dermatol. 2011;28(1):39-45.</mixed-citation></citation-alternatives></ref><ref id="B18"><label>18.</label><citation-alternatives><mixed-citation xml:lang="en">18. Mo J.Q., Dimashkieh H.H., Bove K.E. GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular mal- formation with associated capillary proliferation. Hum Pathol. 2004;35(2):200-209.</mixed-citation><mixed-citation xml:lang="ru">Mo J.Q., Dimashkieh H.H., Bove K.E. GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular mal- formation with associated capillary proliferation. Hum Pathol. 2004;35(2):200-209.</mixed-citation></citation-alternatives></ref><ref id="B19"><label>19.</label><citation-alternatives><mixed-citation xml:lang="en">19. Pratt G.A. Birthmarks in infants. AMA Arch Derm Syphilol. 1953;67(3):302-305.</mixed-citation><mixed-citation xml:lang="ru">Pratt G.A. Birthmarks in infants. AMA Arch Derm Syphilol. 1953;67(3):302-305.</mixed-citation></citation-alternatives></ref><ref id="B20"><label>20.</label><citation-alternatives><mixed-citation xml:lang="en">20. Yeh I., Bruckne A.L., Sanchez R., Jeng M.R., Newell B.D., Frieden I.J. Diffuse infantile hepatic hemangiomas: а report of four cases successfully managed with medical therapy. Pediatr Dermatol. 2011;28(3):267-275</mixed-citation><mixed-citation xml:lang="ru">Yeh I., Bruckne A.L., Sanchez R., Jeng M.R., Newell B.D., Frieden I.J. Diffuse infantile hepatic hemangiomas: а report of four cases successfully managed with medical therapy. Pediatr Dermatol. 2011;28(3):267-275</mixed-citation></citation-alternatives></ref></ref-list></back></article>
