Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children80410.24287/1726-1708-2023-22-4-151-157LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫMolecular biology of nephroblastoma in the context of kidney developmentМолекулярная биология нефробластомы в контексте развития почечной тканиhttps://orcid.org/0000-0002-6042-9795KislyakI. A.КислякИ. А.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0003-1308-8622DruyA. E.ДруйА. Е.
Russian Federation

Alexander E. Druy, Cand. Med. Sci., Head of the  Laboratory of Molecular Oncology

1 Samory Mashela St., Moscow 117997

Друй Александр Евгеньевич, канд. мед. наук,  заведующий лабораторией молекулярной онкологии

117997, Москва, ул. Саморы Машела, 1

dr-drui@yandex.ruDmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России201220232241511570501202405012024Copyright ©; 2023, «D. Rogachev NMRCPHOI»Copyright ©; 2023, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2023«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/804

This paper presents a literature review of nephroblastoma molecular biology. In this article, we explored protein-coding genes in which mutations are the most common cause of Wilms’ tumor. We analyzed the role of these genes both in normal renal development and in Wilms’ tumorigenesis. Our special attention was focused on the embryonic development of the kidneys and how mutations in certain genes can disrupt normal nephrogenesis leading to the emergence of nephroblastoma.

В данной работе представлен обзор литературы по молекулярной биологии нефробластомы. Рассмотрены белок-кодирующие гены, мутации в которых наиболее часто приводят к развитию опухоли Вильмса. Проанализирована роль этих генов как в нормальном формировании почечной ткани, так и при патологии. Особое внимание уделено развитию почек в эмбриональном периоде и тому, как те или иные мутации в ключевых генах могут нарушать нормальное формирование ткани почки, приводя к возникновению нефробластомы.

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