Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children81510.24287/1726-1708-2024-23-1-180-191LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫCurrent views on the etiology and pathogenesis of ALK-positive anaplastic large cell lymphomaСовременные представления об этиологии и патогенезе ALK-позитивной анапластической крупноклеточной лимфомыhttps://orcid.org/0000-0003-3664-2876AbramovD. S.АбрамовД. С.
Russian Federation

Dmitry S. Abramov, MD, a pathologist

Pathology Department

117997; 1 Samory Mashela St.; Moscow

Дмитрий Сергеевич Абрамов, врач-патологоанатом

патологоанатомическое отделение

117997; ул. Саморы Машела, 1; Москва

abramovd_s@bk.ruhttps://orcid.org/0000-0002-4699-1730FedorovaA. S.ФедороваА. С.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0002-2574-1636VolchkovE. V.ВолчковЕ. В.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0002-4779-1896MyakovaN. V.МяковаН. В.
Russian Federation

Moscow

Москва

https://orcid.org/0000-0001-7732-8184KonovalovD. M.КоноваловД. М.
Russian Federation

Moscow

Москва

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthсare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииResearch Institute of Molecular and Cellular Medicine of the Patrice Lumumba Рeoples’ Friendship University of RussiaНаучно-исследовательский институт молекулярной и клеточной медицины ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы»Russian Medical Academy of Continuous Professional Education of Ministry of Healthcare of the Russian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России190420242311801912901202407022024Copyright ©; 2024, «D. Rogachev NMRCPHOI»Copyright ©; 2024, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2024«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/815

   ALK-positive anaplastic large cell lymphoma is a mature T-cell lymphoma characterized by translocations that involve the ALK receptor tyrosine kinase coding gene. This illness is known to almost exclusively affect children and young adults. The biology of ALK-positive anaplastic large cell lymphoma is fairly well researched today, with recent studies focusing on the histogenesis of this neoplasm. In this review, we analyze the existing world literature data on the etiology and pathogenesis of this disease.

   ALK-позитивная анапластическая крупноклеточная лимфома представляет собой зрелоклеточную T-клеточную лимфому, характеризующуюся транслокациями с вовлечением гена, кодирующего рецепторную тирозинкиназу ALK. Одной из особенностей заболевания является его встречаемость почти исключительно среди детей и молодых взрослых. Биология ALK-позитивной анапластической лимфомы на сегодняшний день изучена достаточно хорошо, причем исследования последних лет уделяют большое внимание гистогенезу неоплазии. Настоящий обзор посвящен анализу современных мировых данных об этиологии и патогенезе данного заболевания.

ALK-positive anaplastic large cell lymphomanon-Hodgkin lymphomassignal pathwaysALK-позитивная анапластическая крупноклеточная лимфоманеходжкинские лимфомысигнальные путиNot specifiedНе указанLowe E.J., Gross T.G. Anaplastic large cell lymphoma in children and adolescents. Pediatr Hematol Oncol 2013; 30 (6): 509–19. DOI: 10.3109/08880018.2013.805347Stein H., Foss H.D., Durkop H., Marafioti T., Delsol G., Pulford K., et al. CD30+ anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. Blood 2000; 96 (12): 3681–95. DOI: 10.1182/BLOOD.V96.12.3681Falini B., Lamant L., Campo E., Jaffe E.S., Gascoyne R.D., Stein H., et al. Anaplastic large cell lymphoma, ALK positive. In: Swerdlow S.H., Campo E., Harris N.L., Jaffe E.S., Pileri S.A., Stein H. (eds.). Who Classification of Tumors of Hematopoietic and Lymphoid Tissues. IARC: Lyon (France); 2017. 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