Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children81610.24287/1726-1708-2024-23-1-172-179LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫMolecular pathogenesis of T-lymphoblastic lymphomaМолекулярный патогенез T-лимфобластной лимфомыhttps://orcid.org/0009-0002-3896-6612DneprovskiiV. R.ДнепровскийВ. Р.
Russian Federation

Moscow

Владимир Романович Днепровский

Москва

dneprovsky.vladimir@mail.ruhttps://orcid.org/0000-0002-4699-1730FedorovaA. S.ФёдороваА. С.
Russian Federation

Moscow

Анна Сергеевна Фёдорова

Москва

fyodorova_hannah@mail.ruhttps://orcid.org/0000-0003-3664-2876AbramovD. S.АбрамовД. С.
Russian Federation

Moscow

Дмитрий Сергеевич Абрамов

Москва

abramovd_s@bk.ruhttps://orcid.org/0000-0002-2574-1636VolchkovE. V.ВолчковЕ. В.
Russian Federation

Egor V. Volchkov, a hematologist

Lymphoma Research Department

117997; 1 Samory Mashela St.; Moscow

Егор Васильевич Волчков, врач-гематолог

отдел исследования лимфом

117997; ул. Саморы Машела, 1; Москва

volchcov.egor@yandex.ruhttps://orcid.org/0000-0002-4779-1896MyakovaN. V.МяковаН. В.
Russian Federation

Moscow

Наталья Валерьевна Мякова

Москва

nmiakova@mail.ruThe Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthсare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииResearch Institute of Molecular and Cellular Medicine of the Patrice Lumumba Рeoples’ Friendship University of RussiaНаучно-исследовательский институт молекулярной и клеточной медицины ФГАОУ ВО «Российский университет дружбы народов им. Патриса Лумумбы»190420242311721793101202408042024Copyright ©; 2024, «D. Rogachev NMRCPHOI»Copyright ©; 2024, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2024«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/816

   T-lymphoblastic lymphoma (T-LBL) is one of the most common non-Hodgkin lymphomas in children. According to the 2022 WHO classification, T-LBL and acute T-lymphoblastic leukemia are considered as a single disease since they both have T-cell precursors as a morphological substrate. In recent years, some progress has been made in the treatment of this disease, but the prognosis for relapses and refractory cases remains extremely unfavorable. One of the promising areas that can increase the effectiveness of therapy is the use of new treatment approaches that consider the molecular and biological features of this tumor. This review examines in detail the molecular aspects of the pathogenesis of T-LBL.

   Т-лимфобластная лимфома (Т-ЛБЛ) занимает одно из ведущих мест в структуре неходжкинских лимфом у детей. По классификации Всемирной организации здравоохранения 2022 г. Т-ЛБЛ и острый Т-лимфобластный лейкоз рассматриваются в рамках единой нозологической категории, так как они имеют один и тот же морфологический субстрат – предшественники Т-клеток. За последние годы в лечении этого заболевания достигнуты определенные успехи, однако прогноз при рецидивах и рефрактерном течении до сих пор остается крайне неблагоприятным. Одним из перспективных направлений, способных повысить эффективность терапии, является внедрение новых схем лечения, учитывающих молекулярно-генетические особенности данной опухоли. В настоящем обзоре подробно рассматриваются молекулярные аспекты патогенеза Т-ЛБЛ.

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