Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children8310.24287/1726-1708-2017-16-1-69-82СтатьиThe overview of fibrinolysis system contemporary concepts and of its disorders diagnostic methodsСовременные представления о системе фибринолиза и методах диагностики ее нарушенийZhalyalovA. S.ЖаляловА. С.
Russian Federation
BalandinaA. N.БаландинаА. Н.
Russian Federation
KuprashA. D.КупрашА. Д.
Russian Federation
SrivastavaA.ШриваставаА. .
India
ShibekoA. M.ШибекоА. М.
Russian Federation

PhD in biophysics, leading researcher, Laboratory of Cell Physiology and Biophysics

+7 (495) 938-2533

alshibeko@gmail.comCenter for Theoretical Problems of Physicochemical Pharmacology RASЦентр теоретических проблем физико-химической фармакологии РАН, Москва, РоссияCenter for Theoretical Problems of Physicochemical Pharmacology RAS National Scientific and Practical Centre of Pediatric Hematology, Oncology and Immunology n.a. D. Rogachev"Центр теоретических проблем физико-химической фармакологии РАН, Москва, Россия. - ФГБУ «Национальный научно-практический центр детской гематологии, онкологии и иммунологииCenter for Theoretical Problems of Physicochemical Pharmacology RAS National Scientific and Practical Centre of Pediatric Hematology, Oncology and Immunology n.a. D. Rogachev"Центр теоретических проблем физико-химической фармакологии РАН, Москва, Россия. - ФГБУ «Национальный научно-практический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, МоскваChristian Medical College, Vellore, IndiaХристианский медицинский колледж, Веллор, Индия10022017161698210082018Copyright ©; 2017, «D. Rogachev NMRCPHOI»Copyright ©; 2017, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2017«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/83

Fibrinolysis is an important biochemical process responsible for the dissolution of fibrin clots, which appear during the blood coagulation process. Disorders in fibrinolysis system may result in life-threatening conditions like thrombosis and bleedings. At this time, we know a lot about the molecular mechanism of fibrinolysis, all reactions are described in details, and yet its regulation and evaluation of fibrinolysis state are still unclear. In this review we analyze the information about how fibrinolysis functions and what disorders of this system can be met. We describe in details the methods used to evaluate the state of fibrinolysis system.

Фибринолиз - важный биохимический процесс, отвечающий за разрушение фибриновых сгустков, образующихся в результате работы системы свертывания. Сбои в работе системы фибринолиза могут приводить к состояниям, угрожающим жизни, - тромбозам и неконтролируемым кровотечениям. Наблюдается стремительный прогресс в понимании молекулярных механизмов работы системы фибринолиза, детально описаны все основные участники и реакции процесса, тем не менее вопросы регуляции и оценки состояния системы фибринолиза изучены слабо. В данном обзоре представлен анализ накопленной информации о работе системы фибринолиза и сопутствующей патологии. Подробно рассмотрены методы оценки и диагностики состояния системы фибринолиза.

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