Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children8410.24287/1726-1708-2017-16-1-83-95СтатьиModern approach to diagnosis of inherited functional platelet disordersДиагностика врожденных нарушений функций тромбоцитов: современное состояние вопросаFedorovaD. V.ФёдороваД. В.
Russian Federation

MD, pediatrician of Outpatient Consultative Unit

Russia 117997, Moscow, Samory Mashela st., 1

+7 (495) 287-6570, ext. 1702

darya.v.fedorova@gmail.comZharkovP. A.ЖарковП. А.
Russian Federation
PlyasunovaS. A.ПлясуноваС. А.
Russian Federation
SereginaE. A.СерёгинаЕ. А.
Russian Federation
IgnatovaA. A.ИгнатоваА. А.
Russian Federation
National Scientific and Practical Centre of Pediatric Hematology, Oncology and Immunology named after Dmitry RogachevФГБУ «Национальный научно-практический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России, Москва10022017161839510082018Copyright ©; 2017, «D. Rogachev NMRCPHOI»Copyright ©; 2017, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2017«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/84

Inherited functional platelet disorders (IFPD) are very heterogeneous group of hemorrhagic diseases that are difficult to diagnose. Prevalence of IFPD in general population is probably underestimated. In most cases IFPD cause mild to moderate bleeding symptoms in everyday life but may result in life-threating bleeding after trauma and surgical interventions. Rational diagnostic approach is critical to prevent these complications. Data on diagnostic algorithms as well as on benefits and disadvantages of specific laboratory methods are presented in this review. Approach to clinical evaluation is also reviewed with particular attention to bleeding assessment tools. The main emphasis is made on light transmission aggregometry, measurement of platelet granules content and release, flow cytometry. Problems of standardization of platelet functional tests are outlined. Diagnostic algorithms are applied according to the up to date recommendations of International Society on Thrombosis and Haemostasis.

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