Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children8810.24287/1726-1708-2015-14-1-38-45ОСТРЫЙ ЛИМФОБЛАСТНЫЙ ЛЕЙКОЗEarly T-cell precursor acute lymphoblastic leukemiaОстрый лимфобластный лейкоз из ранних предшественников Т-клетокBoichenkoE. G.БойченкоЭльмира Госмановна
Russian Federation
boychenko-elmira@yandex.ruPopovA. M.ПоповАлександр Михайлович
Russian Federation
uralcytometry@gmail.comMakarovaT. A.МакароваТатьяна Александровна
Russian Federation
tanyamak64@mail.ruDokhinaN. N.ДохинаНаталья Николаевна
Russian Federation
dr.dokhina@inbox.ruGarbuzovaI. A.ГарбузоваИрина Анатольевна
Russian Federation
ira-garbuzova@mail.ruMakarovaO. V.МакароваОльга Владимировна
Russian Federation
childrens_oncology@mail.ruArakaevO. R.АракаевОлег Раисович
Russian Federation
olegarakaev@yandex.ruFechinaL. G.ФечинаЛариса Геннадьевна
Russian Federation
childrens_oncology@mail.ruKarachunskyA. I.КарачунскийАлександр Исаакович
Russian Federation
aikarat@mail.ruMunicipal Pediatric Hospital No. 1Детская городская больница № 1Regional Pediatric Clinical Hospital No. 1Областная детская клиническая больница № 1Institute of Medical Cell TechnologiesИнститут медицинских клеточных технологийRegional Pediatric Clinical Hospital No 1Областная детская клиническая больница № 1Institute of Medical Cell TechnologiesФедеральный научно-клинический центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева Минздрава РоссииFederal Research Center of Pediatric Hematology, Oncology, and Immunology named after Dmitry RogachevРоссийский национальный исследовательский медицинский университет им. Н.И.Пирогова Минздрава РоссииRussian National Research Medical University named after N.I.Pirogov19022015141384519092018Copyright ©; 2015, «D. Rogachev NMRCPHOI»Copyright ©; 2015, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2015«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/88

The transcription and immunological studies of the latest decade have shed new light on the biology of T-cell acute lymphoblastic leukemia (T-ALL) and identified a new T-ALL subtype - early T-cell precursor ALL (ETP-ALL), a tumor from immature hematopoietic precursors which retain their capacity to myeloid differentiation. Identification of the characteristic phenotype of immature T-lymphoblasts is extremely important for the diagnosis of ETP-ALL, when the risk of failure of therapy even by modern protocols is very high. By transcription ETP-ALL is closely related to hematopoietic stem cells and myeloid precursors. The available data indicate that use of drugs active in acute myeloid leukemia can improve the prognosis for patients with ETP-ALL. The unique biology of the tumor and the extremely unfavorable prognosis in ETP-ALL necessitate the creation of a new therapeutic strategy for the treatment of this disease. Two clinical case reports of ETP-ALL are presented, demonstrating variants of extremely unfavorable course of the disease and requiring individual therapeutic approaches.

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