Pediatric Hematology/Oncology and Immunopathology

Вопросы гематологии/онкологии и иммунопатологии в педиатрии

1726-17082414-9314

Fund Doctors, Innovations, Science for Children

905

10.24287/1726-1708-2024-23-3-176-197

LITERATURE REVIEW

ОБЗОР ЛИТЕРАТУРЫ

Potential mechanisms of neurogenic tumor maturation

Возможные механизмы созревания нейрогенных опухолей

Zverev

I. A.

Зверев

И. А.

Russian Federation

Moscow

Москва

https://orcid.org/0000-0003-1308-8622

Druy

A. E.

Друй

А. Е.

Russian Federation

Alexander E. Druy - Cand. Med. Sci., Head of the Laboratory of Molecular Oncology.

1 Samory Mashela St., Moscow 117997

Друй Александр Евгеньевич - канд. мед. наук, заведующий лабораторией молекулярной онкологии

117997, Москва, ул. Саморы Машела, 1

dr-drui@yandex.ru

The N.I. Pirogov Russian National Research Medical University of Ministry of Healthcare of the Russian FederationФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава России

Research Institute of Medical Cell TechnologiesГАУЗ CO «Институт медицинских клеточных технологий»

08092024

233

1761971610202416102024

2025

«D. Rogachev NMRCPHOI»

ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России

https://creativecommons.org/licenses/by/4.0

https://hemoncim.com/jour/article/view/905

In the past years, a significant progress has been achieved in the development of techniques to study morphology and molecular processes within tissues, single cells, and even subcellular structures. This has led to qualitatively new insights into the causes of certain previously unexplained clinical phenomena in oncology, including the rare and paradoxical ability of malignant tumors to become benign. In this review, we critically analyze the existing hypotheses regarding the mechanisms underlying neurogenic tumor maturation, taking into consideration recent data on their origins and biological properties. We also evaluate the potential implications of this knowledge for clinical practice.

В последнее время произошло значительное развитие методов изучения морфологии и молекулярных процессов в тканях, клетках и субклеточных структурах. Благодаря этому появилась возможность получения качественно нового представления о причинах ранее необъяснимых клинических явлений в онкологии. Одним из наиболее загадочных феноменов является редкое парадоксальное свойство злокачественных новообразований становиться доброкачественными. В данном обзоре мы критически рассматриваем существующие гипотезы о механизмах, лежащих в основе созревания нейрогенных опухолей, с учетом новых данных об их происхождении и биологии и оцениваем перспективы применения этих знаний в клинике.

maturationdifferentiationneurogenic tumorsembryonal tumorsneuroblastomacentral nervous system tumors

созреваниедифференцировканейрогенные опухолиэмбриональные опухолинейробластомаопухоли центральной нервной системы

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