Pediatric Hematology/Oncology and ImmunopathologyPediatric Hematology/Oncology and ImmunopathologyВопросы гематологии/онкологии и иммунопатологии в педиатрии1726-17082414-9314Fund Doctors, Innovations, Science for Children93010.24287/1726-1708-2024-23-4-162-167LITERATURE REVIEWОБЗОР ЛИТЕРАТУРЫVitamin K-dependent coagulopathy in neonates and infantsВитамин К-зависимая коагулопатия у новорожденных и детей первых месяцев жизниhttps://orcid.org/0000-0003-4452-5821GolovinaE. M.ГоловинаЕ. М.
Russian Federation

Elena M. Golovina, a research technician at the Laboratory of Hemostasis Disorders at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian Federation; a hematologist at the Department of Pediatric Oncology and Hematology with Chemotherapy at Regional Children’s Clinical Hospital

339 Rifle Division St. 14, Rostov-on-Don 344015

Головина Елена Михайловна, лаборант-исследователь лаборатории патологии гемостаза ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России; врач-гематолог отделения детской онкологии и гематологии с химиотерапией ГБУ РО «Областная детская клиническая больница»

344015, Ростов-на-Дону, ул. 339-й Стрелковой дивизии, 14 

golovinhelen@yandex.ruhttps://orcid.org/0000-0002-3635-8579AslanyanК. S.АсланянК. С.
Russian Federation

Rostov-on-Don

Ростов-на-Дону

The Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of the Russian FederationФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им. Дмитрия Рогачева» Минздрава РоссииRegional Children’s Clinical HospitalГБУ РО «Областная детская клиническая больница»131220242341621671812202418122024Copyright ©; 2024, «D. Rogachev NMRCPHOI»Copyright ©; 2024, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России2024«D. Rogachev NMRCPHOI»ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава Россииhttps://creativecommons.org/licenses/by/4.0https://hemoncim.com/jour/article/view/930

Vitamin K-dependent coagulopathy caused by vitamin K deficiency holds an important place among bleeding disorders in newborns and infants. The late type of this disease is considered to be the most dangerous one because up to 50% of children develop intracranial hemorrhage which often leads to disability or even death if diagnosis is delayed. Here, we report on the prevalence, treatment and prevention of vitamin K-dependent coagulopathy in neonates and infants.

Значимый вклад в структуру геморрагических заболеваний у детей в возрасте до 6 месяцев вносит витамин К-зависимая коагулопатия – заболевание, развивающееся в результате дефицита витамина К. Среди ее форм наиболее грозной является поздняя – до половины случаев сопровождаются внутричерепными кровоизлияниями, которые при несвоевременной диагностике нередко приводят к инвалидизирующим осложнениям и даже летальному исходу. Данный обзор содержит данные о распространенности, подходах к лечению и профилактике витамин К-зависимой коагулопатии у новорожденных и детей первых месяцев жизни.

late hemorrhagic disease of the newbornvitamin Kchildrencoagulopathymenadione sodium bisulfitebleedingпоздняя геморрагическая болезнь новорожденныхвитамин Кдетикоагулопатияменадиона натрия бисульфиткровотечениеNewman P., Shearer M.J. Vitamin K metabolism. Subcell Biochem 1998; 30: 455–88. DOI: 10.1007/978-1- 4899-1789-8_19Shearer M.J. Vitamin K metabolism and nutriture. Blood Rev 1992; 6: 92–104. DOI: 10.1016/0268-960X(92)90011-EClarke P., Mitchell S.J., Shearer M.J. Total and differential phylloquinone (vitamin K1 ) intakes of preterm infants from all sources during the neonatal period. Nutrients 2015; 7 (10): 8308–20. DOI: 10.3390/nu7105393Cornelissen M., von Kries R., Loughnan P., Schubiger G. Prevention of vitamin K deficiency bleeding: Efficacy of different multiple oral dose schedules of vitamin K. Eur J Pediatr 1997; 156: 126–30. DOI: 10.1007/s004310050570Ardell S., Offringa M., Ovelman C., Soll R. Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates. Cochrane Database Syst Rev 2018; 2: CD008342.Zipursky A. Prevention of vitamin K deficiency bleeding in newborns. Br J Haematol 1999; 104: 430–7. DOI: 10.1046/j.1365-2141.1999.01104.xAraki S., Shirahata A. Vitamin K Deficiency Bleeding in Infancy. Nutrients 2020; 12 (3): 780. DOI: 10.3390/nu12030780Centers for Disease Control and Prevention (CDC). Notes from the field: late vitamin K deficiency bleeding in infants whose parents declined vitamin K prophylaxis – Tennessee, 2013. MMWR Morb Mortal Wkly Rep 2013; 62 (45): 901–2.Townsend C.W. The haemorrhagic disease of the newborn. Arch Paediatr 1894; 11: 559–65.Dam H. Vitamin K, its discovery, biochemistry and application in medicine. J Mt Sinai Hosp N Y 1946; 12: 961–70.Dam H., Dyggve H., Larsen H., Plum P. The relation of vitamin K deficiency to hemorrhagic disease of the newborn. Adv Pediatr 1952; 5: 129–53.Jullien S. Vitamin K prophylaxis in newborns. BMC Pediatr 2021; 21 (Suppl 1): 350. DOI: 10.1186/s12887-021-02701-4Sankar M., Chandrasekaran A., Kumar P., Thukral A., Agarwal R., Paul V.K. Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review. J Perinatol 2016; 36 (Suppl 1): S29–35. DOI: 10.1038/jp.2016.30Higuera-Cetina C.I., MontañaGómez L.M., Picón-Jaimes Y.A., Orozco-Chinome J.E., Lozada-Martínez I.D., Moscote-Salazar L.R. Late-Onset Vitamin K Deficiency Bleeding: A Preventable Pathology. J Pediatr Hematol Oncol 2021; 43 (8): e1272–3. DOI: 10.1097/MPH.0000000000002315Bhanchet P., Tuchinda S., Hathirat P., Visudhiphan P., Bhamaraphavati N., Bukkavesa S. A bleeding syndrome in infants due to acquired prothrombin complex deficiency: A survey of 93 affected infants. Clin Pediatr (Phila) 1977; 16: 992–8. DOI: 10.1177/000992287701601106Clinical recommendations for diagnosis and treatment of hemolytic disease of the newborn. М.: Neonatology Association; 2015. [Electronic resource] URL: https://babymed73.ru/upload/medialibrary/b48/b48d7b487be26fb640ef0291c2 e4af2a.pdf (access date: 24.10.2024). (In Russ.)Клинические рекомендации по диагностике и лечению гемолитической болезни новорожденных. М.: Ассоциация неонатологов; 2015. [Электронный ресурс] URL: https://babymed73.ru/upload/medialibrary/b48/b48d7b487be26fb640ef0291c2e4af2a.pdf (дата обращения 24.10.2024).Hanawa Y., Maki M., Murata B., Matsuyama E., Yamamoto Y., Nagao T., et al. The second nation-wide survey in Japan of vitamin K deficiency in infancy. Eur J Pediatr 1988; 147: 472–7. DOI: 10.1007/BF00441969Schulte R., Jordan L.C., Morad A., Naftel R.P., Wellons J.C., Sidonio R. Rise in Late Onset Vitamin K Deficiency Bleeding in Young Infants Because of Omission or Refusal of Prophylaxis at Birth. Pediatr Neurol 2014; 50: 564–8.von Kries R., Hanawa Y. Neonatal vitamin K prophylaxis. Report of Scientific and Standardization Subcommittee on Perinatal Haemostasis. Thromb Haemost 1993; 69: 293–5.Elalfy M., Eltonbary K., Elalfy O., Gadallah M., Zidan A., AbdelHady H. Intracranial haemorrhage associated with Vitamin K deficiency in Egyptian infants. Acta Paediatr 2021; 110 (11): 2937–43. DOI: 10.1111/apa.16011Elalfy M., Eltonbary K., Elalfy O., Gadallah M., Zidan A., Abdel-Hady H. Intracranial haemorrhage associated with Vitamin K deficiency in Egyptian infants. Acta Paediatr 2021; 110 (11): 2937–43. DOI: 10.1111/apa.16011Al-Zuhairy S.H. Late vitamin K deficiency bleeding in infants: five-year prospective study. J Pediatr (Rio J) 2021; 97 (5): 514–9. DOI: 10.1016/j.jped.2020.09.003Vikasol package insert. [Electronic resource] URL: https://grls.pharm-portal.ru/grls/f91087d4-4eaf406b-891a-48d0efcfc475#dosageForms (access date: 24.10.2024). (In Russ.)Инструкция к применению препарата «Викасол». [Электронный ресурс] URL: https://grls.pharm-portal.ru/grls/f91087d4-4eaf-406b-891a-48d0efcfc475#dosageForms (дата обращения 24.10.2024).Shearer M.J. Vitamin K deficiency bleeding (VKDB) in early infancy. Blood Rev 2009; 23: 49–59. DOI: 10.1016/j.blre.2008.06.001Lembo C., Buonocore G., Perrone S. The challenge to define the optimal prophylactic regimen for vitamin K deficiency bleeding in infants. Acta Paediatr 2021; 110 (4): 1113–8. DOI: 10.1111/apa.15566American Academy of Pediatrics. Report of the Committee on Nutrition: vitamin K compounds and the water-soluble analogues. Pediatrics 1961; 28: 501–6.American Academy of Pediatrics Vitamin K Ad Hoc Task Force. Controversies concerning vitamin K and the newborn. Pediatrics 1993; 91: 1001–3.American Academy of Pediatrics Committee on Fetus and Newborn. Controversies concerning vitamin K and the newborn. American Academy of Pediatrics Committee on Fetus and Newborn Pediatrics 2003; 112: 191–2.Darlow B.A., Phillips A.A., Dickson N.P. New Zealand surveillance of neonatal vitamin K deficiency bleeding (VKDB): 1998–2008. J Paediatr Child Health 2011; 47: 460–4.Busfield A., Samuel R., McNinch A., Tripp J.H. Vitamin K deficiency bleeding after NICE guidance and withdrawal of Konakion Neonatal: British Paediatric Surveillance Unit study. Arch Dis Child 2013; 98: 41–7.World Health Organization. WHO recommendations on newborn health. Guidelines approved by the WHO guidelines review committee. Geneva; 2017. [Electronic resource] URL: https://apps.who.int/iris/bitstream/handle/10665/259269/WHO-MCA-17.07-eng.pdf;jsessionid=CF264F9448EAE361B5BE63F6B8BD284B?sequence=1 (cited 2019 Jun 10).World Health Organization. Recommendations for management of common childhood conditions: evidence for technical update of pocket book recommendations. 2012. [Electronic resource] URL: https://apps.who.int/iris/bitstream/handle/10665/44774/9789241502825_eng.pdf?sequence=1 (cited 2019 Jun 25).American Academy of Pediatrics. AAP publications reaffirmed or retired. Pediatrics 2020; 145 (6): 2020–2.Schubiger G., Berger T.M., Weber R., Bänziger O., Laubscher B.; Swiss Paediatric Surveillance Unit. Prevention of vitamin K deficiency bleeding with oral mixed micellar phylloquinone: results of a 6-year surveillance in Switzerland. Eur J Pediatr 2003; 162: 885–8.von Kries R., Hachmeister A., Göbel U. Oral mixed micellar vitamin K for prevention of late vitamin K deficiency bleeding. Arch Dis Child Fetal Neonatal Ed 2003; 88: F109–12.Federal clinical guidelines for diagnosis and treatment of hemorrhagic disease of the newborn. M.: Dmitry Rogachev NMRCPHOI of Ministry of Healthcare of Russia, National Society of Pediatric Hematologists and Oncologists of Russia; 2014. [Electronic resource] URL: http://nodgo.org/sites/default/files/ФКР%20по%20диагностике%20и%20лечению20геморрагической%20болезни%20новорожденных.pdf (access date: 24.10.2024). (In Russ.)Федеральные клинические рекомендации по диагностике и лечению геморрагической болезни новорожденных. М.: ФГБУ «ФНКЦ ДГОИ им. Дмитрия Рогачева» Минздрава России, Национальное общество детских гематологов, онкологов России; 2014. [Электронный ресурс] URL: http://nodgo.org/sites/default/files/ФКР%20по%20диагностике%20и%20лечению%20геморрагической%20болезни%20новорожденных.pdf (дата обращения 24.10.2024).Chawla D., Deorari A.K., Saxena R., Paul V.K., Agarwal R., Biswas A., Meena A. Vitamin K1 versus vitamin K3 for prevention of subclinical vitamin deficiency: a randomized controlled trial. Indian Pediatr 2007; 44 (11): 817–22.Dyggve H.V., Dam H., Søndergaard E. Comparison of the action of vitamin K1 with that of synkavit in the newborn. Acta Paediatr (Stockh) 1954; 43 (1): 27–31. DOI: 10.1111/j.1651-2227.1954.tb03995.xGreer F.R. Controversies in neonatal nutrition: macronutrients and micronutrients. In: Gastroenterology and nutrition: neonatology question and controversies. 2nd ed. by Neu J. Philadelphia: Elsevier saunders; 2012. Pp. 129–155.Mihatsch W.A., Braegger C., Bronsky J., Campoy C., Domellöf M., Fewtrell M., et al.; ESPGHAN Committee on Nutrition. Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr 2016; 63 (1): 123–9. DOI: 10.1097/MPG.0000000000001232Takahashi D., Shirahata A., Itoh S., Takahashi Y., Nishiguchi T., Matsuda Y. Vitamin K prophylaxis and late vitamin K deficiency bleeding in infants: fifth nationwide survey in Japan. Pediatr Int 2011; 53 (6): 897–901. DOI: 10.1111/j.1442-200X.2011.03392.xSutor A.H., Dagres N., Niederhoff H. Late form of vitamin K deficiency bleeding in Germany. Klin Padiatr 1995; 207 (3): 89–97. DOI: 10.1055/s-2008-1046519Autret-Leca E., Jonville-Bera A.P. Vitamin K in neonates: how to administer, when and to whom. Paediatr Drugs 2001; 3: 1–8.Yilmaz C., Yuca S.A., Yilmaz N., Bektaş M.S., Caksen H. Intracranial hemorrhage due to vitamin K deficiency in infants: a clinical study. Int J Neurosci 2009; 119 (12): 2250–6. DOI: 10.3109/00207450903170437Zaplatnikov A.L., Brazhnikova O.V., Gavelya N.V., Nikitin V.V., Ashurova B.A., Koroleva A.S., et al. To the question of “late hemorrhagic disease of the newborn”. Russian Medical Journal 2017; (19): 1331–4. (In Russ.)Заплатников А.Л., Бражникова О.В., Гавеля Н.В., Никитин В.В., Ашурова Б.А., Королева А.С. и др. К вопросу о «поздней геморрагической болезни новорожденного». Русский медицинский журнал 2017; (19): 1331–4.