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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Pediatric Hematology/Oncology and Immunopathology</journal-id><journal-title-group><journal-title xml:lang="en">Pediatric Hematology/Oncology and Immunopathology</journal-title><trans-title-group xml:lang="ru"><trans-title>Вопросы гематологии/онкологии и иммунопатологии в педиатрии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1726-1708</issn><issn publication-format="electronic">2414-9314</issn><publisher><publisher-name xml:lang="en">Fund Doctors, Innovations, Science for Children</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">94</article-id><article-id pub-id-type="doi">10.24287/1726-1708-2015-14-1-65-75</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL PHARMACOLOGY AND PHARMACOTHERAPY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ ФАРМАКОЛОГИЯ И ФАРМАКОТЕРАПИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Efficiency and safety of Innonafactor in prevention of bleeding episodes in patients with severe and moderate hemophilia B: Results of part 1 of phase II-III clinical trial</article-title><trans-title-group xml:lang="ru"><trans-title>Эффективность и безопасность препарата Иннонафактор при профилактическом лечении больных с тяжелой и среднетяжелой формой гемофилии B (результаты 1-й части клинического исследования II-III фазы)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Andreeva</surname><given-names>T. A.</given-names></name><name xml:lang="ru"><surname>Андреева</surname><given-names>Татьяна Андреевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>spbhemophilia@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zorenko</surname><given-names>V. Yu.</given-names></name><name xml:lang="ru"><surname>Зоренко</surname><given-names>Владимир Юрьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>v.zorenko@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Davydkin</surname><given-names>I. L.</given-names></name><name xml:lang="ru"><surname>Давыдкин</surname><given-names>Игорь Леонидович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>dagi2006@rambler.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Konstantinova</surname><given-names>V. N.</given-names></name><name xml:lang="ru"><surname>Константинова</surname><given-names>Валерия Николаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>spbhemophilia@mail.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zalepukhina</surname><given-names>O. E.</given-names></name><name xml:lang="ru"><surname>Залепухина</surname><given-names>Ольга Эрвиновна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>spbhemophilia@mail.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Klimova</surname><given-names>N. I.</given-names></name><name xml:lang="ru"><surname>Климова</surname><given-names>Нина Ивановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>spbhemophilia@mail.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mishin</surname><given-names>G. V.</given-names></name><name xml:lang="ru"><surname>Мишин</surname><given-names>Георгий Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>georgiy-mishin@yandex.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Krechetova</surname><given-names>A. V.</given-names></name><name xml:lang="ru"><surname>Кречетова</surname><given-names>Анна Васильевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kurtov</surname><given-names>I. V.</given-names></name><name xml:lang="ru"><surname>Куртов</surname><given-names>Игорь Валентинович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>sam-med@mail.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shamina</surname><given-names>M. S.</given-names></name><name xml:lang="ru"><surname>Шамина</surname><given-names>Мария Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>mashel83@yandex.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fatenkova</surname><given-names>E. S.</given-names></name><name xml:lang="ru"><surname>Фатенкова</surname><given-names>Елена Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gusyakova</surname><given-names>O. A.</given-names></name><name xml:lang="ru"><surname>Гусякова</surname><given-names>Оксана Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>apkrf2@rambler.ru</email></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shuster</surname><given-names>A. M.</given-names></name><name xml:lang="ru"><surname>Шустер</surname><given-names>Александр Михайлович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>generium@generiumzao.ru</email><xref ref-type="aff" rid="aff11"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kudlai</surname><given-names>D. A.</given-names></name><name xml:lang="ru"><surname>Кудлай</surname><given-names>Дмитрий Анатольевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>dakudlay@generiumzao.ru</email><xref ref-type="aff" rid="aff11"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lukyanov</surname><given-names>S. V.</given-names></name><name xml:lang="ru"><surname>Лукьянов</surname><given-names>Сергей Викторович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>s.lukyanov@generiumzao.ru</email><xref ref-type="aff" rid="aff11"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Borozinets</surname><given-names>A. Yu.</given-names></name><name xml:lang="ru"><surname>Борозинец</surname><given-names>Антон Юрьевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>a.borozinets@generiumzao.ru</email><xref ref-type="aff" rid="aff11"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Municipal Health Center No. 37</institution></aff><aff><institution xml:lang="ru">Городская поликлиника № 37</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Hematological Research Center</institution></aff><aff><institution xml:lang="ru">Гематологический научный центр Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Institute of Hematology, Transfusiology, and Intensive Care, Samara State Medical University</institution></aff><aff><institution xml:lang="ru">НИИ гематологии, трансфузиологии и интенсивной терапии Самарский государственный медицинский университет Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="ru">Самарский государственный медицинский университет Минздрава России</institution></aff><aff><institution xml:lang="en">Municipal Health Center No. 37</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="ru">Городский центр по лечению гемофилии</institution></aff><aff><institution xml:lang="en">Municipal Health Center No. 37</institution></aff></aff-alternatives><aff-alternatives id="aff6"><aff><institution xml:lang="ru">Городский центр по лечению гемофилии</institution></aff><aff><institution xml:lang="en">Hematological Research Center</institution></aff></aff-alternatives><aff-alternatives id="aff7"><aff><institution xml:lang="ru">Гематологический научный центр Минздрава России</institution></aff><aff><institution xml:lang="en">Institute of Hematology, Transfusiology, and Intensive Care, Samara State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff8"><aff><institution xml:lang="ru">Самарский государственный медицинский университет Минздрава России</institution></aff><aff><institution xml:lang="en">Institute of Hematology, Transfusiology, and Intensive Care, Samara State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff9"><aff><institution xml:lang="ru">Самарский государственный медицинский университет Минздрава России</institution></aff><aff><institution xml:lang="en">GENERIUM</institution></aff></aff-alternatives><aff-alternatives id="aff10"><aff><institution xml:lang="ru">ЗАО «ГЕНЕРИУМ»</institution></aff><aff><institution xml:lang="en">GENERIUM</institution></aff></aff-alternatives><aff id="aff11"><institution>ЗАО «ГЕНЕРИУМ»</institution></aff><pub-date date-type="pub" iso-8601-date="2015-02-19" publication-format="electronic"><day>19</day><month>02</month><year>2015</year></pub-date><volume>14</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>65</fpage><lpage>75</lpage><history><date date-type="received" iso-8601-date="2018-09-19"><day>19</day><month>09</month><year>2018</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, «D. Rogachev NMRCPHOI»</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">«D. Rogachev NMRCPHOI»</copyright-holder><copyright-holder xml:lang="ru">ФГБУ «НМИЦ ДГОИ им. Дмитрия Рогачева» Минздрава России</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://hemoncim.com/jour/article/view/94">https://hemoncim.com/jour/article/view/94</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="ru"><kwd>гемофилия B</kwd><kwd>рекомбинантный препарат фактора IX</kwd><kwd>Иннонафактор</kwd><kwd>Октанайн Ф</kwd><kwd>профилактическое лечение</kwd><kwd>эффективность</kwd><kwd>безопасность</kwd><kwd>hemophilia B</kwd><kwd>recombinant factor IX</kwd><kwd>Innonafactor</kwd><kwd>Octanine F</kwd><kwd>prophylaxis</kwd><kwd>efficacy</kwd><kwd>safety</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Srivastava A., Brewer A.K., Mauser-Bunschoten E.P., Key N.S., Kitchen S., Llinas A. et al. 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